1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	S	P	R	E	P	L	V	P	P	P	T	P	R	P	A	A	T	V	M	L	V	R	D	P	D	A	G	S	A	S	G	L	A	V	F	L	M	R	R	H	A	A	M	D	F	A	A	G	V	M	V	F	P	G	G	G	V	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?											?	?	?	?	?	?	?												?	?	?	?	?	?	?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	R	D	R	D	A	D	L	G	R	L	G	A	W	A	G	P	P	P	Q	W	W	A	Q	R	F	G	I	E	P	D	L	A	E	A	L	V	C	A	A	A	R	E	T	F	E	E	S	G	V	L	F	A	G	P	V	D	Q	D	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?											?								?		?	?	?																										?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	A	P	N	S	I	V	S	D	A	S	V	Y	G	D	A	R	R	A	L	A	D	R	T	L	S	F	A	D	F	L	Q	R	E	K	L	V	L	R	S	D	L	L	R	P	W	A	N	W	V	T	P	E	A	E	L	T	R	R	Y
Secondary structure
SS confidence
Disorder		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	T	Y	F	F	V	G	A	L	P	E	G	Q	R	A	D	G	E	N	T	E	S	D	R	A	G	W	V	L	P	A	D	A	I	A	D	F	A	A	G	R	N	F	L	L	P	P	T	W	T	Q	L	D	S	L	A	G	H	T	V
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.
Sequence		A	D	V	L	A	V	E	R	Q	I	V	P	V	Q	P	Q	L	A	R	N	G	D	N	W	E	I	E	F	F	D	S	D	R	Y	N	Q	A	R	R	S	G	G	S	T	G	W	P	L
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 29%) Beta strand ( 19%)

Rank Aligned region

PDB 3qsj chain A Region: 12 - 252 Aligned: 219 Modelled: 241 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from alicyclobacillus2 acidocaldarius Phyre2 PDB 5t3p chain B Region: 10 - 215 Aligned: 122 Modelled: 128 Confidence: 99.5% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:peroxisomal coenzyme a diphosphatase nudt7; PDBTitle: crystal structure of human peroxisomal coenzyme a diphosphatase nudt7 Phyre2 PDB 4dyw chain A Region: 13 - 236 Aligned: 128 Modelled: 147 Confidence: 99.4% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of mutt nudix hydrolase from burkholderia2 pseudomallei Phyre2 PDB 1sjy chain A Region: 11 - 225 Aligned: 126 Modelled: 136 Confidence: 99.4% Identity: 28% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2b0v chain A domain 1 Region: 13 - 215 Aligned: 114 Modelled: 126 Confidence: 99.4% Identity: 22% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5gg7 chain A Region: 16 - 216 Aligned: 108 Modelled: 124 Confidence: 99.4% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family protein; PDBTitle: crystal structure of mycobacterium smegmatis mutt1 in complex with 8-2 oxo-dgtp, 8-oxo-dgmp and pyrophosphate (i) Phyre2 PDB 1ktg chain A Region: 16 - 216 Aligned: 115 Modelled: 125 Confidence: 99.4% Identity: 24% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 1jkn chain A Region: 5 - 216 Aligned: 133 Modelled: 145 Confidence: 99.3% Identity: 28% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2fkb chain A domain 1 Region: 14 - 215 Aligned: 112 Modelled: 123 Confidence: 99.3% Identity: 23% Fold: Nudix Superfamily: Nudix Family: IPP isomerase-like Phyre2 PDB 1nqz chain A Region: 5 - 215 Aligned: 120 Modelled: 126 Confidence: 99.3% Identity: 29% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2kdv chain A Region: 15 - 215 Aligned: 113 Modelled: 120 Confidence: 99.3% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:rna pyrophosphohydrolase; PDBTitle: solution structure of rna pyrophosphohydrolase rpph from2 escherichia coli Phyre2 PDB 5lf8 chain A Region: 18 - 215 Aligned: 115 Modelled: 120 Confidence: 99.3% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:nucleoside diphosphate-linked moiety x motif 17; PDBTitle: human nucleoside diphosphate-linked moiety x motif 17 (nudt17) Phyre2 PDB 1ppv chain A Region: 17 - 238 Aligned: 138 Modelled: 146 Confidence: 99.3% Identity: 18% Fold: Nudix Superfamily: Nudix Family: IPP isomerase-like Phyre2 PDB 3son chain B Region: 15 - 215 Aligned: 120 Modelled: 128 Confidence: 99.3% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:hypothetical nudix hydrolase; PDBTitle: crystal structure of a putativel nudix hydrolase (lmof2365_2679) from2 listeria monocytogenes str. 4b f2365 at 1.70 a resolution Phyre2 PDB 1xsb chain A Region: 11 - 215 Aligned: 124 Modelled: 129 Confidence: 99.3% Identity: 16% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5cfi chain C Region: 16 - 215 Aligned: 109 Modelled: 121 Confidence: 99.2% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:bis(5'-nucleosyl)-tetraphosphatase (diadenosine PDBTitle: structural and functional attributes of malaria parasite ap4a2 hydrolase Phyre2 PDB 4kyx chain A Region: 14 - 213 Aligned: 113 Modelled: 123 Confidence: 99.2% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:adp-ribose pyrophosphatase mutt; PDBTitle: crystal structure of adp-ribose pyrophosphatase mutt from rickettsia2 felis Phyre2 PDB 3grn chain B Region: 15 - 215 Aligned: 111 Modelled: 122 Confidence: 99.2% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:mutt related protein; PDBTitle: crystal structure of mutt protein from methanosarcina mazei go1 Phyre2 PDB 3hhj chain A Region: 18 - 238 Aligned: 125 Modelled: 144 Confidence: 99.2% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:mutator mutt protein; PDBTitle: crystal structure of mutator mutt from bartonella henselae Phyre2 PDB 3fjy chain B Region: 16 - 216 Aligned: 119 Modelled: 124 Confidence: 99.2% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:probable mutt1 protein; PDBTitle: crystal structure of a probable mutt1 protein from bifidobacterium2 adolescentis Phyre2 1 c3qsjA_ 2 c5t3pB_ 3 c4dywA_ 4 d1sjya_ 5 d2b0va1 6 c5gg7A_ 7 d1ktga_ 8 d1jkna_ 9 d2fkba1 10 d1nqza_ 11 c2kdvA_ 12 c5lf8A_ 13 d1ppva_ 14 c3sonB_ 15 d1xsba_ 16 c5cfiC_ 17 c4kyxA_ 18 c3grnB_ 19 c3hhjA_ 20 c3fjyB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123