1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	N	L	Y	D	A	D	G	K	I	Q	F	D	K	D	R	E	A	A	H	Q	Y	F	L	Q	H	V	N	Q	N	T	V	F	F	H	N	Q	D	E	K	L	D	Y	L	I	R	E	N	Y	Y	E	R	E	V	L	D	Q	Y	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	N	F	V	K	T	L	L	D	R	A	Y	A	K	K	F	R	F	P	T	F	L	G	A	F	K	Y	Y	T	S	Y	T	L	K	T	F	D	G	K	R	Y	L	E	R	F	E	D	R	V	V	M	V	A	L	T	L	A	A	G	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	A	L	A	E	L	L	V	D	E	I	I	D	G	R	F	Q	P	A	T	P	T	F	L	N	S	G	K	K	Q	R	G	E	P	V	S	C	F	L	L	R	V	E	D	N	M	E	S	I	G	R	S	I	N	S	A	L	Q	L	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	R	G	G	G	V	A	L	L	L	T	N	I	R	E	H	G	A	P	I	K	N	I	E	N	Q	S	S	G	V	I	P	I	M	K	L	L	E	D	A	F	S	Y	A	N	Q	L	G	A	R	Q	G	A	G	A	V	Y	L	H	A
Secondary structure
SS confidence
Disorder																?					?	?	?	?		?			?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	H	P	D	I	Y	R	F	L	D	T	K	R	E	N	A	D	E	K	I	R	I	K	T	L	S	L	G	V	V	I	P	D	I	T	F	E	L	A	K	R	N	D	D	M	Y	L	F	S	P	Y	D	V	E	R	V	Y	G	V	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	A	D	I	S	V	T	E	K	Y	Y	E	M	V	D	D	A	R	I	R	K	T	K	I	K	A	R	E	F	F	Q	T	L	A	E	L	Q	F	E	S	G	Y	P	Y	I	M	F	E	D	T	V	N	R	A	N	P	I	D	G	K
Secondary structure
SS confidence
Disorder																		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	T	H	S	N	L	C	S	E	I	L	Q	V	S	T	P	S	L	F	N	E	D	L	S	Y	A	K	V	G	K	D	I	S	C	N	L	G	S	L	N	I	A	K	T	M	D	S	P	D	F	A	Q	T	I	E	V	A	I	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	T	A	V	S	D	Q	T	H	I	K	S	V	P	S	I	E	Q	G	N	N	D	S	H	A	I	G	L	G	Q	M	N	L	H	G	Y	L	A	R	E	R	I	F	Y	G	S	D	E	G	I	D	F	T	N	I	Y	F	Y	T	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		L	Y	H	A	L	R	A	S	N	R	I	A	I	E	R	G	T	H	F	K	G	F	E	R	S	K	Y	A	S	G	E	F	F	D	K	Y	T	D	Q	I	W	E	P	K	T	Q	K	V	R	Q	L	F	A	D	A	G	I	R	I	P
Secondary structure
SS confidence
Disorder																																								?				?										?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		T	Q	D	D	W	R	R	L	K	E	S	V	Q	A	H	G	I	Y	N	Q	N	L	Q	A	V	P	P	T	G	S	I	S	Y	I	N	H	S	T	S	S	I	H	P	I	V	S	K	V	E	I	R	K	E	G	K	I	G	R	V	Y
Secondary structure
SS confidence
Disorder																																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		Y	P	A	P	Y	M	T	N	D	N	L	E	Y	Y	E	D	A	Y	E	I	G	Y	E	K	I	I	D	T	Y	A	A	A	T	Q	H	V	D	Q	G	L	S	L	T	L	F	F	K	D	T	A	T	T	R	D	V	N	K	A	Q	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.
Sequence		Y	A	W	R	K	G	I	K	T	L	Y	Y	I	R	L	R	Q	M	A	L	E	G	T	E	V	E	G	C	V	S	C	M	L
Secondary structure
SS confidence
Disorder																			?	?	?	?	?		?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 48%) Beta strand ( 10%)

Rank Aligned region

PDB 1pem chain A Region: 1 - 678 Aligned: 673 Modelled: 678 Confidence: 100.0% Identity: 72% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase 2 alpha PDBTitle: ribonucleotide reductase protein r1e from salmonella2 typhimurium Phyre2 PDB 6cgm chain A Region: 4 - 676 Aligned: 644 Modelled: 673 Confidence: 100.0% Identity: 48% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: x-ray crystal structure of bacillus subtilis ribonucleotide reductase2 nrde alpha subunit (nucleotide free) Phyre2 PDB 3r1r chain B Region: 12 - 677 Aligned: 645 Modelled: 654 Confidence: 100.0% Identity: 24% PDB header:complex (oxidoreductase/peptide) Chain: B: PDB Molecule:ribonucleotide reductase r1 protein; PDBTitle: ribonucleotide reductase r1 protein with amppnp occupying2 the activity site from escherichia coli Phyre2 PDB 1zyz chain A Region: 10 - 680 Aligned: 630 Modelled: 641 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain 1; PDBTitle: structures of yeast ribonucloetide reductase i Phyre2 PDB 2wgh chain A Region: 20 - 676 Aligned: 617 Modelled: 625 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large PDBTitle: human ribonucleotide reductase r1 subunit (rrm1) in complex2 with datp and mg. Phyre2 PDB 2cvu chain A Region: 30 - 676 Aligned: 606 Modelled: 617 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain PDBTitle: structures of yeast ribonucleotide reductase i Phyre2 PDB 5im3 chain A Region: 12 - 679 Aligned: 634 Modelled: 649 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: crystal structure of the class i ribonucleotide reductase from2 pseudomonas aeruginosa in complex with datp Phyre2 PDB 3hnf chain A Region: 10 - 676 Aligned: 614 Modelled: 637 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large subunit; PDBTitle: crystal structure of human ribonucleotide reductase 1 bound to the2 effectors ttp and datp Phyre2 PDB 3rsr chain A Region: 30 - 676 Aligned: 585 Modelled: 614 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain 1; PDBTitle: crystal structure of 5-nitp inhibition of yeast ribonucleotide2 reductase Phyre2 PDB 3paw chain D Region: 10 - 676 Aligned: 623 Modelled: 630 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase large chain 1; PDBTitle: low resolution x-ray crystal structure of yeast rnr1p with datp bound2 in the a-site Phyre2 PDB 1xje chain A Region: 66 - 677 Aligned: 542 Modelled: 551 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase, b12-dependent; PDBTitle: structural mechanism of allosteric substrate specificity in a2 ribonucleotide reductase: dttp-gdp complex Phyre2 PDB 1rlr chain A domain 2 Region: 154 - 693 Aligned: 514 Modelled: 534 Confidence: 100.0% Identity: 27% Fold: PFL-like glycyl radical enzymes Superfamily: PFL-like glycyl radical enzymes Family: R1 subunit of ribonucleotide reductase, C-terminal domain Phyre2 PDB 1peq chain A domain 2 Region: 154 - 678 Aligned: 512 Modelled: 525 Confidence: 100.0% Identity: 74% Fold: PFL-like glycyl radical enzymes Superfamily: PFL-like glycyl radical enzymes Family: R1 subunit of ribonucleotide reductase, C-terminal domain Phyre2 PDB 6dqx chain A Region: 72 - 683 Aligned: 487 Modelled: 510 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase, alpha chain; PDBTitle: actinobacillus ureae class id ribonucleotide reductase alpha subunit Phyre2 PDB 6dqw chain B Region: 75 - 675 Aligned: 470 Modelled: 499 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase, alpha chain; PDBTitle: flavobacterium johnsoniae class id ribonucleotide reductase alpha2 subuint Phyre2 PDB 6dqw chain D Region: 94 - 672 Aligned: 377 Modelled: 425 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase, alpha chain; PDBTitle: flavobacterium johnsoniae class id ribonucleotide reductase alpha2 subuint Phyre2 PDB 1l1l chain A Region: 65 - 681 Aligned: 518 Modelled: 534 Confidence: 100.0% Identity: 19% Fold: PFL-like glycyl radical enzymes Superfamily: PFL-like glycyl radical enzymes Family: B12-dependent (class II) ribonucleotide reductase Phyre2 PDB 1peq chain A domain 1 Region: 1 - 153 Aligned: 153 Modelled: 153 Confidence: 100.0% Identity: 64% Fold: R1 subunit of ribonucleotide reductase, N-terminal domain Superfamily: R1 subunit of ribonucleotide reductase, N-terminal domain Family: R1 subunit of ribonucleotide reductase, N-terminal domain Phyre2 PDB 1rlr chain A domain 1 Region: 12 - 153 Aligned: 141 Modelled: 142 Confidence: 100.0% Identity: 11% Fold: R1 subunit of ribonucleotide reductase, N-terminal domain Superfamily: R1 subunit of ribonucleotide reductase, N-terminal domain Family: R1 subunit of ribonucleotide reductase, N-terminal domain Phyre2 PDB 4u3e chain A Region: 328 - 691 Aligned: 259 Modelled: 265 Confidence: 98.2% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside triphosphate reductase; PDBTitle: anaerobic ribonucleotide reductase Phyre2 1 c1pemA_ 2 c6cgmA_ 3 c3r1rB_ 4 c1zyzA_ 5 c2wghA_ 6 c2cvuA_ 7 c5im3A_ 8 c3hnfA_ 9 c3rsrA_ 10 c3pawD_ 11 c1xjeA_ 12 d1rlra2 13 d1peqa2 14 c6dqxA_ 15 c6dqwB_ 16 c6dqwD_ 17 d1l1la_ 18 d1peqa1 19 d1rlra1 20 c4u3eA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99