1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	I	Y	L	Y	L	L	C	A	I	F	A	E	V	V	A	T	S	L	L	K	S	T	E	G	F	T	R	L	W	P	T	V	G	C	L	V	G	Y	G	I	A	F	A	L	L	A	L	S	I	S	H	G	M	Q	T	D	V	A	Y
Secondary structure
SS confidence
Disorder		?																							?	?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.
Sequence		A	L	W	S	A	I	G	T	A	A	I	V	L	V	A	V	L	F	L	G	S	P	I	S	V	M	K	V	V	G	V	G	L	I	V	V	G	V	V	T	L	N	L	A	G	A	H
Secondary structure
SS confidence
Disorder																																													?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 85%) Beta strand ( 0%) TM helix ( 70%) (View membrane topology prediction)

Rank Aligned region

PDB 1s7b chain A Region: 4 - 105 Aligned: 101 Modelled: 102 Confidence: 100.0% Identity: 43% Fold: Multidrug resistance efflux transporter EmrE Superfamily: Multidrug resistance efflux transporter EmrE Family: Multidrug resistance efflux transporter EmrE Phyre2 PDB 2i68 chain B Region: 3 - 103 Aligned: 77 Modelled: 101 Confidence: 99.8% Identity: 45% PDB header:transport protein Chain: B: PDB Molecule:protein emre; PDBTitle: cryo-em based theoretical model structure of transmembrane2 domain of the multidrug-resistance antiporter from e. coli3 emre Phyre2 PDB 6oh2 chain A Region: 4 - 103 Aligned: 98 Modelled: 100 Confidence: 98.1% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:cmp-sialic acid transporter; PDBTitle: x-ray crystal structure of the mouse cmp-sialic acid transporter in2 complex with cmp, by lipidic cubic phase Phyre2 PDB 5i20 chain E Region: 24 - 107 Aligned: 82 Modelled: 84 Confidence: 98.0% Identity: 20% PDB header:membrane protein Chain: E: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein Phyre2 PDB 6i1r chain A Region: 21 - 103 Aligned: 81 Modelled: 83 Confidence: 97.9% Identity: 5% PDB header:membrane protein Chain: A: PDB Molecule:cmp-sialic acid transporter 1; PDBTitle: crystal structure of cmp bound cst in an outward facing conformation Phyre2 PDB 5y79 chain A Region: 29 - 104 Aligned: 74 Modelled: 76 Confidence: 97.8% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:putative hexose phosphate translocator; PDBTitle: crystal structure of the triose-phosphate/phosphate translocator in2 complex with 3-phosphoglycerate Phyre2 PDB 5oge chain E Region: 21 - 107 Aligned: 85 Modelled: 87 Confidence: 97.6% Identity: 12% PDB header:membrane protein Chain: E: PDB Molecule:gdp-mannose transporter 1; PDBTitle: crystal structure of a nucleotide sugar transporter Phyre2 PDB 5i20 chain C Region: 21 - 107 Aligned: 85 Modelled: 87 Confidence: 97.5% Identity: 15% PDB header:membrane protein Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein Phyre2 PDB 4oo9 chain A Region: 55 - 85 Aligned: 31 Modelled: 31 Confidence: 18.9% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:metabotropic glutamate receptor 5, lysozyme, metabotropic PDBTitle: structure of the human class c gpcr metabotropic glutamate receptor 52 transmembrane domain in complex with the negative allosteric3 modulator mavoglurant Phyre2 PDB 3mp7 chain B Region: 85 - 101 Aligned: 17 Modelled: 17 Confidence: 16.2% Identity: 29% PDB header:protein transport Chain: B: PDB Molecule:preprotein translocase subunit sece; PDBTitle: lateral opening of a translocon upon entry of protein suggests the2 mechanism of insertion into membranes Phyre2 PDB 2lp1 chain A Region: 77 - 100 Aligned: 24 Modelled: 24 Confidence: 9.0% Identity: 33% PDB header:membrane protein Chain: A: PDB Molecule:c99; PDBTitle: the solution nmr structure of the transmembrane c-terminal domain of2 the amyloid precursor protein (c99) Phyre2 PDB 5xnm chain J Region: 67 - 80 Aligned: 14 Modelled: 14 Confidence: 8.7% Identity: 36% PDB header:membrane protein Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: structure of unstacked c2s2m2-type psii-lhcii supercomplex from pisum2 sativum Phyre2 PDB 5azc chain A Region: 27 - 101 Aligned: 75 Modelled: 75 Confidence: 7.9% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:prolipoprotein diacylglyceryl transferase; PDBTitle: crystal structure of escherichia coli lgt in complex with2 phosphatidylglycerol Phyre2 PDB 3jcu chain J Region: 67 - 80 Aligned: 14 Modelled: 14 Confidence: 7.7% Identity: 43% PDB header:membrane protein Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: cryo-em structure of spinach psii-lhcii supercomplex at 3.2 angstrom2 resolution Phyre2 PDB 6e8w chain C Region: 92 - 103 Aligned: 12 Modelled: 12 Confidence: 6.8% Identity: 25% PDB header:viral protein Chain: C: PDB Molecule:envelope glycoprotein gp160; PDBTitle: mper-tm domain of hiv-1 envelope glycoprotein (env) Phyre2 PDB 5dir chain B Region: 68 - 100 Aligned: 33 Modelled: 33 Confidence: 6.7% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:lipoprotein signal peptidase; PDBTitle: membrane protein at 2.8 angstroms Phyre2 PDB 5doq chain C Region: 43 - 66 Aligned: 23 Modelled: 24 Confidence: 6.5% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:putative membrane protein; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 5ir6 chain C Region: 43 - 66 Aligned: 23 Modelled: 24 Confidence: 6.5% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:putative membrane protein; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 6m97 chain A Region: 13 - 80 Aligned: 60 Modelled: 68 Confidence: 6.3% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:chimera protein of high affinity copper uptake protein 1 PDBTitle: crystal structure of the high-affinity copper transporter ctr1 Phyre2 PDB 3a0h chain J Region: 67 - 80 Aligned: 14 Modelled: 14 Confidence: 5.5% Identity: 43% PDB header:electron transport Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: crystal structure of i-substituted photosystem ii complex Phyre2 1 d1s7ba_ 2 c2i68B_ 3 c6oh2A_ 4 c5i20E_ 5 c6i1rA_ 6 c5y79A_ 7 c5ogeE_ 8 c5i20C_ 9 c4oo9A_ 10 c3mp7B_ 11 c2lp1A_ 12 c5xnmj_ 13 c5azcA_ 14 c3jcuj_ 15 c6e8wC_ 16 c5dirB_ 17 c5doqC_ 18 c5ir6C_ 19 c6m97A_ 20 c3a0hJ_ 21