1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	A	N	P	R	A	G	Q	P	A	Q	P	E	D	L	V	D	L	P	H	L	V	T	A	Y	Y	S	I	E	P	D	P	D	D	L	A	Q	Q	V	A	F	G	T	S	G	H	R	G	S	A	L	T	G	T	F	N	E	L	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																	?	?		?	?	?	?	?	?	?	?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	L	A	I	T	Q	A	I	V	E	Y	R	A	A	Q	G	T	T	G	P	L	F	I	G	R	D	T	H	G	L	S	E	P	A	W	V	S	A	L	E	V	L	A	A	N	Q	V	V	A	V	V	D	S	R	D	R	Y	T	P	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	A	I	S	H	A	I	L	T	Y	N	R	G	R	T	E	A	L	A	D	G	I	V	V	T	P	S	H	N	P	P	S	D	G	G	I	K	Y	N	P	P	N	G	G	P	A	D	T	A	A	T	T	A	I	A	K	R	A	N	E
Secondary structure
SS confidence
Disorder											?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	L	L	A	R	S	M	V	K	R	L	P	L	A	R	A	L	R	T	A	Q	R	H	D	Y	L	G	H	Y	V	D	D	L	P	N	V	V	D	I	A	A	I	R	E	A	G	V	R	I	G	A	D	P	L	G	G	A	S	V	D
Secondary structure
SS confidence
Disorder									?									?																						?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	W	G	E	I	A	H	R	H	G	L	D	L	T	V	V	N	P	L	V	D	A	T	W	R	F	M	T	L	D	T	D	G	K	I	R	M	D	C	S	S	P	D	A	M	A	G	L	I	R	T	M	F	G	N	R	E	R	Y	Q
Secondary structure
SS confidence
Disorder																																					?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	A	T	G	N	D	A	D	A	D	R	H	G	I	V	T	P	D	E	G	L	L	N	P	N	H	Y	L	A	V	A	I	E	Y	L	Y	T	H	R	P	S	W	P	A	G	I	A	V	G	K	T	V	V	S	S	S	I	I	D	R
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	V	A	G	I	G	R	Q	L	V	E	V	P	V	G	F	K	W	F	V	D	G	L	I	G	A	T	L	G	F	G	G	E	E	S	A	G	A	S	F	L	R	R	D	G	S	V	W	T	T	D	K	D	G	I	I	M	A	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	A	E	I	L	A	V	T	G	A	T	P	S	Q	R	Y	H	A	L	A	G	E	Y	G	G	P	C	Y	A	R	I	D	A	P	A	D	R	E	Q	K	A	R	L	A	R	L	S	A	D	Q	V	S	A	T	E	L	A	G	E	P
Secondary structure
SS confidence
Disorder																																																	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		I	T	A	K	L	T	T	A	P	G	N	G	A	A	L	G	G	L	K	V	T	T	A	N	A	W	F	A	A	R	P	S	G	T	E	D	V	Y	K	I	Y	A	E	S	F	R	G	P	Q	H	L	V	E	V	Q	Q	T	A	R	E
Secondary structure
SS confidence
Disorder									?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		V	V	D	R	V	I	G
Secondary structure
SS confidence
Disorder							?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 39%) Beta strand ( 18%)

Rank Aligned region

PDB 2fuv chain B Region: 4 - 546 Aligned: 537 Modelled: 543 Confidence: 100.0% Identity: 56% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucomutase; PDBTitle: phosphoglucomutase from salmonella typhimurium. Phyre2 PDB 2z0f chain A Region: 17 - 546 Aligned: 489 Modelled: 495 Confidence: 100.0% Identity: 55% PDB header:isomerase Chain: A: PDB Molecule:putative phosphoglucomutase; PDBTitle: crystal structure of putative phosphoglucomutase from thermus2 thermophilus hb8 Phyre2 PDB 1c4g chain B Region: 28 - 546 Aligned: 496 Modelled: 496 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:protein (alpha-d-glucose 1-phosphate phosphoglucomutase); PDBTitle: phosphoglucomutase vanadate based transition state analog complex Phyre2 PDB 1kfi chain A Region: 33 - 547 Aligned: 496 Modelled: 515 Confidence: 100.0% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:phosphoglucomutase 1; PDBTitle: crystal structure of the exocytosis-sensitive2 phosphoprotein, pp63/parafusin (phosphoglucomutase) from3 paramecium Phyre2 PDB 1wqa chain B Region: 38 - 546 Aligned: 452 Modelled: 479 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: B: PDB Molecule:phospho-sugar mutase; PDBTitle: crystal structure of pyrococcus horikoshii2 phosphomannomutase/phosphoglucomutase complexed with mg2+ Phyre2 PDB 2f7l chain A Region: 38 - 543 Aligned: 451 Modelled: 492 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: A: PDB Molecule:455aa long hypothetical phospho-sugar mutase; PDBTitle: crystal structure of sulfolobus tokodaii2 phosphomannomutase/phosphoglucomutase Phyre2 PDB 3pdk chain B Region: 42 - 547 Aligned: 441 Modelled: 469 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucosamine mutase; PDBTitle: crystal structure of phosphoglucosamine mutase from b. anthracis Phyre2 PDB 3c04 chain A Region: 36 - 546 Aligned: 446 Modelled: 497 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:phosphomannomutase/phosphoglucomutase; PDBTitle: structure of the p368g mutant of pmm/pgm from p. aeruginosa Phyre2 PDB 6gyz chain B Region: 42 - 547 Aligned: 441 Modelled: 482 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucosamine mutase; PDBTitle: crystal structure of glmm from staphylococcus aureus Phyre2 PDB 1tuo chain A Region: 37 - 543 Aligned: 434 Modelled: 479 Confidence: 100.0% Identity: 26% PDB header:biosynthetic protein Chain: A: PDB Molecule:putative phosphomannomutase; PDBTitle: crystal structure of putative phosphomannomutase from2 thermus thermophilus hb8 Phyre2 PDB 3uw2 chain A Region: 38 - 545 Aligned: 445 Modelled: 492 Confidence: 100.0% Identity: 22% PDB header:isomerase Chain: A: PDB Molecule:phosphoglucomutase/phosphomannomutase family protein; PDBTitle: x-ray crystal structure of phosphoglucomutase/phosphomannomutase2 family protein (bth_i1489)from burkholderia thailandensis Phyre2 PDB 5bmp chain A Region: 42 - 543 Aligned: 440 Modelled: 484 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:phosphoglucomutase; PDBTitle: crystal structure of phosphoglucomutase from xanthomonas citri2 complexed with glucose-1-phosphate Phyre2 PDB 3i3w chain B Region: 42 - 546 Aligned: 437 Modelled: 476 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucosamine mutase; PDBTitle: structure of a phosphoglucosamine mutase from francisella tularensis Phyre2 PDB 4hjh chain A Region: 38 - 546 Aligned: 452 Modelled: 481 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: A: PDB Molecule:phosphomannomutase; PDBTitle: iodide sad phased crystal structure of a phosphoglucomutase from2 brucella melitensis complexed with glucose-6-phosphate Phyre2 PDB 4qg5 chain D Region: 65 - 527 Aligned: 457 Modelled: 463 Confidence: 100.0% Identity: 25% PDB header:isomerase Chain: D: PDB Molecule:putative phosphoglucomutase; PDBTitle: crystal structure of phosphoglucomutase from leishmania major at 3.52 angstrom resolution Phyre2 PDB 2dkd chain A Region: 64 - 543 Aligned: 430 Modelled: 435 Confidence: 100.0% Identity: 19% PDB header:isomerase Chain: A: PDB Molecule:phosphoacetylglucosamine mutase; PDBTitle: crystal structure of n-acetylglucosamine-phosphate mutase,2 a member of the alpha-d-phosphohexomutase superfamily, in3 the product complex Phyre2 PDB 4bju chain B Region: 62 - 547 Aligned: 432 Modelled: 444 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:n-acetylglucosamine-phosphate mutase; PDBTitle: genetic and structural validation of aspergillus fumigatus2 n-acetylphosphoglucosamine mutase as an antifungal target Phyre2 PDB 1kfi chain A domain 1 Region: 29 - 207 Aligned: 177 Modelled: 179 Confidence: 100.0% Identity: 25% Fold: Phosphoglucomutase, first 3 domains Superfamily: Phosphoglucomutase, first 3 domains Family: Phosphoglucomutase, first 3 domains Phyre2 PDB 3pmg chain A domain 1 Region: 27 - 218 Aligned: 184 Modelled: 192 Confidence: 100.0% Identity: 27% Fold: Phosphoglucomutase, first 3 domains Superfamily: Phosphoglucomutase, first 3 domains Family: Phosphoglucomutase, first 3 domains Phyre2 PDB 1p5d chain X domain 1 Region: 36 - 187 Aligned: 138 Modelled: 152 Confidence: 100.0% Identity: 23% Fold: Phosphoglucomutase, first 3 domains Superfamily: Phosphoglucomutase, first 3 domains Family: Phosphoglucomutase, first 3 domains Phyre2 1 c2fuvB_ 2 c2z0fA_ 3 c1c4gB_ 4 c1kfiA_ 5 c1wqaB_ 6 c2f7lA_ 7 c3pdkB_ 8 c3c04A_ 9 c6gyzB_ 10 c1tuoA_ 11 c3uw2A_ 12 c5bmpA_ 13 c3i3wB_ 14 c4hjhA_ 15 c4qg5D_ 16 c2dkdA_ 17 c4bjuB_ 18 d1kfia1 19 d3pmga1 20 d1p5dx1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106