1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	N	H	D	Y	R	E	L	A	A	V	F	A	G	G	A	L	G	A	L	A	R	A	A	L	S	A	L	A	I	P	D	P	A	R	W	P	W	P	T	F	T	V	N	V	V	G	A	F	L	V	G	Y	F	T	T	R	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	R	L	P	L	S	S	Y	R	R	P	L	L	G	T	G	L	C	G	G	L	T	T	F	S	T	M	Q	V	E	T	I	S	M	I	E	H	G	H	W	G	L	A	A	A	Y	S	V	V	S	I	T	L	G	L	L	A	V	H	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.
Sequence		A	T	V	L	V	R	R	V	R	I	R	R
Secondary structure
SS confidence
Disorder										?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 83%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 5a43 chain B Region: 5 - 128 Aligned: 124 Modelled: 123 Confidence: 100.0% Identity: 27% PDB header:transport protein Chain: B: PDB Molecule:putative fluoride ion transporter crcb; PDBTitle: crystal structure of a dual topology fluoride ion channel. Phyre2 PDB 5a40 chain C Region: 8 - 130 Aligned: 121 Modelled: 123 Confidence: 100.0% Identity: 35% PDB header:transport protein Chain: C: PDB Molecule:putative fluoride ion transporter crcb; PDBTitle: crystal structure of a dual topology fluoride ion channel. Phyre2 PDB 4hzu chain S Region: 1 - 129 Aligned: 126 Modelled: 127 Confidence: 56.1% Identity: 10% PDB header:hydrolase, transport protein Chain: S: PDB Molecule:predicted membrane protein; PDBTitle: structure of a bacterial energy-coupling factor transporter Phyre2 PDB 3hd6 chain A Region: 38 - 132 Aligned: 95 Modelled: 95 Confidence: 42.1% Identity: 11% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg Phyre2 PDB 5egi chain B Region: 2 - 67 Aligned: 60 Modelled: 66 Confidence: 18.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:uncharacterized protein y57a10a.10; PDBTitle: structure of a trimeric intracellular cation channel from c. elegans2 with bound ca2+ Phyre2 PDB 5eik chain A Region: 2 - 67 Aligned: 60 Modelled: 66 Confidence: 17.6% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:uncharacterized protein y57a10a.28; PDBTitle: structure of a trimeric intracellular cation channel from c. elegans2 in the absence of ca2+ Phyre2 PDB 5edl chain A Region: 43 - 131 Aligned: 87 Modelled: 89 Confidence: 14.6% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:putative hmp/thiamine permease protein ykoe; PDBTitle: crystal structure of an s-component of ecf transporter Phyre2 PDB 2d10 chain F Region: 2 - 8 Aligned: 7 Modelled: 7 Confidence: 13.4% Identity: 29% PDB header:cell adhesion Chain: F: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 2d10 chain H Region: 2 - 8 Aligned: 7 Modelled: 7 Confidence: 13.4% Identity: 29% PDB header:cell adhesion Chain: H: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 2d10 chain G Region: 2 - 8 Aligned: 7 Modelled: 7 Confidence: 13.4% Identity: 29% PDB header:cell adhesion Chain: G: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 2d10 chain E Region: 2 - 8 Aligned: 7 Modelled: 7 Confidence: 13.4% Identity: 29% PDB header:cell adhesion Chain: E: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 1sgh chain B Region: 2 - 8 Aligned: 7 Modelled: 7 Confidence: 11.7% Identity: 29% PDB header:structural protein Chain: B: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: moesin ferm domain bound to ebp50 c-terminal peptide Phyre2 PDB 5aez chain A Region: 13 - 89 Aligned: 77 Modelled: 77 Confidence: 10.9% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:mep2; PDBTitle: crystal structure of candida albicans mep2 Phyre2 PDB 5aex chain J Region: 2 - 89 Aligned: 88 Modelled: 88 Confidence: 9.8% Identity: 11% PDB header:membrane protein Chain: J: PDB Molecule:ammonium transporter mep2; PDBTitle: crystal structure of saccharomyces cerevisiae mep2 Phyre2 PDB 3org chain B Region: 2 - 128 Aligned: 127 Modelled: 127 Confidence: 9.2% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:cmclc; PDBTitle: crystal structure of a eukaryotic clc transporter Phyre2 PDB 5ws4 chain A Region: 6 - 60 Aligned: 55 Modelled: 55 Confidence: 8.8% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: crystal structure of tripartite-type abc transporter macb from2 acinetobacter baumannii Phyre2 PDB 5lj7 chain B Region: 6 - 60 Aligned: 55 Modelled: 55 Confidence: 8.7% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: structure of aggregatibacter actinomycetemcomitans macb bound to atp2 (p21) Phyre2 PDB 5xvj chain B Region: 1 - 35 Aligned: 35 Modelled: 35 Confidence: 7.9% Identity: 29% PDB header:gene regulation Chain: B: PDB Molecule:phd finger protein alfin-like 7; PDBTitle: crystal structure of al7 pal domain Phyre2 PDB 2d11 chain G Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 7.5% Identity: 40% PDB header:cell adhesion Chain: G: PDB Molecule:na(+)/h(+) exchange regulatory cofactor nhe-rf2; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-2 c-terminal tail peptide Phyre2 PDB 2d11 chain H Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 7.5% Identity: 40% PDB header:cell adhesion Chain: H: PDB Molecule:na(+)/h(+) exchange regulatory cofactor nhe-rf2; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-2 c-terminal tail peptide Phyre2 1 c5a43B_ 2 c5a40C_ 3 c4hzuS_ 4 c3hd6A_ 5 c5egiB_ 6 c5eikA_ 7 c5edlA_ 8 c2d10F_ 9 c2d10H_ 10 c2d10G_ 11 c2d10E_ 12 c1sghB_ 13 c5aezA_ 14 c5aexJ_ 15 c3orgB_ 16 c5ws4A_ 17 c5lj7B_ 18 c5xvjB_ 19 c2d11G_ 20 c2d11H_ 21 22 23 24 25 26 27 28 29 30