1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	E	Q	C	L	K	L	T	A	Y	F	G	E	R	Q	R	A	V	G	G	A	G	R	F	L	A	D	A	M	L	D	L	F	G	S	H	N	V	A	T	S	V	M	L	R	G	T	T	S	F	G	P	K	H	E	F	R	C	D
Secondary structure
SS confidence
Disorder		?	?	?	?																?	?		?																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	S	L	S	L	S	E	D	P	P	V	T	V	A	A	V	D	I	E	S	K	I	R	S	L	V	D	D	V	T	A	M	T	D	R	G	L	V	T	L	E	R	A	R	L	V	T	R	H	S	G	A	E	E	F	G	D	I	D	S
Secondary structure
SS confidence
Disorder					?	?																																											?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	N	G	D	A	A	K	L	T	I	Y	A	G	R	Q	V	R	V	A	G	A	P	A	Y	Y	T	I	C	E	L	L	H	R	H	G	F	A	G	A	T	V	L	L	G	V	D	G	T	A	H	G	R	R	R	R	A	R	F	F	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?										?			?		?																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	N	V	N	V	P	L	M	I	I	A	V	G	T	P	A	Q	V	A	V	A	A	M	E	L	T	A	A	L	P	N	P	L	L	T	I	E	R	V	R	L	C	K	R	D	G	E	L	F	A	R	P	Q	Q	L	P	Q	T	D	D
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	G	R	T	L	W	Q	K	L	M	V	H	T	A	E	A	T	H	H	E	G	L	P	I	H	R	A	L	V	H	R	L	M	Q	S	E	T	A	R	G	A	T	A	L	R	G	I	W	G	F	Y	G	D	H	K	P	H	G	D	K
Secondary structure
SS confidence
Disorder		?	?		?															?		?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	F	Q	L	V	R	R	V	P	V	T	T	I	I	V	D	T	P	Q	A	I	A	R	S	F	D	I	V	D	E	L	T	N	W	H	G	L	V	T	S	E	M	V	P	A	A	V	S	L	T	G	S	R	D	G	T	Q	K	T	G
Secondary structure
SS confidence
Disorder				?																																																		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		E	T	P	L	A	R	Y	D	Y
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 22%) Beta strand ( 37%)

Rank Aligned region

PDB 2dcl chain B Region: 2 - 108 Aligned: 93 Modelled: 107 Confidence: 100.0% Identity: 30% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical upf0166 protein ph1503; PDBTitle: structure of ph1503 protein from pyrococcus horikoshii ot3 Phyre2 PDB 1o51 chain A Region: 4 - 106 Aligned: 87 Modelled: 102 Confidence: 100.0% Identity: 25% Fold: Ferredoxin-like Superfamily: GlnB-like Family: DUF190/COG1993 Phyre2 PDB 5d4p chain A Region: 1 - 107 Aligned: 93 Modelled: 105 Confidence: 99.5% Identity: 16% PDB header:signaling protein Chain: A: PDB Molecule:putative nitrogen regulatory protein p-ii glnb; PDBTitle: structure of cpii bound to adp and bicarbonate, from thiomonas2 intermedia k12 Phyre2 PDB 2cz4 chain A domain 1 Region: 4 - 107 Aligned: 88 Modelled: 104 Confidence: 97.1% Identity: 11% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 2ns1 chain B domain 1 Region: 23 - 96 Aligned: 73 Modelled: 74 Confidence: 94.3% Identity: 15% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 2rd5 chain D Region: 3 - 96 Aligned: 83 Modelled: 93 Confidence: 94.2% Identity: 13% PDB header:protein binding Chain: D: PDB Molecule:pii protein; PDBTitle: structural basis for the regulation of n-acetylglutamate kinase by pii2 in arabidopsis thaliana Phyre2 PDB 1vfj chain A Region: 23 - 96 Aligned: 73 Modelled: 74 Confidence: 94.2% Identity: 12% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 2pii chain A Region: 23 - 96 Aligned: 73 Modelled: 74 Confidence: 93.9% Identity: 15% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 3o8w chain A Region: 23 - 96 Aligned: 68 Modelled: 69 Confidence: 93.1% Identity: 10% PDB header:signaling protein Chain: A: PDB Molecule:nitrogen regulatory protein p-ii (glnb-1); PDBTitle: archaeoglobus fulgidus glnk1 Phyre2 PDB 1ul3 chain A Region: 265 - 364 Aligned: 79 Modelled: 86 Confidence: 91.6% Identity: 18% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 1qy7 chain A Region: 23 - 113 Aligned: 90 Modelled: 91 Confidence: 91.1% Identity: 12% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 2j9d chain G Region: 23 - 96 Aligned: 63 Modelled: 74 Confidence: 89.6% Identity: 10% PDB header:membrane transport Chain: G: PDB Molecule:hypothetical nitrogen regulatory pii-like PDBTitle: structure of glnk1 with bound effectors indicates2 regulatory mechanism for ammonia uptake Phyre2 PDB 3mhy chain C Region: 23 - 96 Aligned: 73 Modelled: 74 Confidence: 89.4% Identity: 18% PDB header:signaling protein Chain: C: PDB Molecule:pii-like protein pz; PDBTitle: a new pii protein structure Phyre2 PDB 4r25 chain A Region: 27 - 96 Aligned: 69 Modelled: 69 Confidence: 87.9% Identity: 9% PDB header:transcription Chain: A: PDB Molecule:nitrogen regulatory pii-like protein; PDBTitle: structure of b. subtilis glnk Phyre2 PDB 3ncp chain D Region: 23 - 96 Aligned: 63 Modelled: 62 Confidence: 86.9% Identity: 11% PDB header:signaling protein Chain: D: PDB Molecule:nitrogen regulatory protein p-ii (glnb-2); PDBTitle: glnk2 from archaeoglobus fulgidus Phyre2 PDB 1hwu chain A Region: 23 - 96 Aligned: 63 Modelled: 72 Confidence: 85.7% Identity: 19% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 4usi chain C Region: 23 - 96 Aligned: 65 Modelled: 66 Confidence: 83.3% Identity: 11% PDB header:signaling protein Chain: C: PDB Molecule:nitrogen regulatory protein pii; PDBTitle: nitrogen regulatory protein pii from chlamydomonas2 reinhardtii in complex with mgatp and 2-oxoglutarate Phyre2 PDB 1xtz chain A Region: 188 - 331 Aligned: 122 Modelled: 144 Confidence: 81.8% Identity: 14% PDB header:isomerase Chain: A: PDB Molecule:ribose-5-phosphate isomerase; PDBTitle: crystal structure of the s. cerevisiae d-ribose-5-phosphate isomerase:2 comparison with the archeal and bacterial enzymes Phyre2 PDB 4ozl chain A Region: 23 - 115 Aligned: 80 Modelled: 93 Confidence: 81.7% Identity: 9% PDB header:signaling protein Chain: A: PDB Molecule:nitrogen regulatory protein p-ii; PDBTitle: glnk2 from haloferax mediterranei complexed with amp Phyre2 PDB 2f1f chain A domain 2 Region: 57 - 92 Aligned: 35 Modelled: 36 Confidence: 79.2% Identity: 11% Fold: Ferredoxin-like Superfamily: ACT-like Family: IlvH-like Phyre2 1 c2dclB_ 2 d1o51a_ 3 c5d4pA_ 4 d2cz4a1 5 d2ns1b1 6 c2rd5D_ 7 d1vfja_ 8 d2piia_ 9 c3o8wA_ 10 d1ul3a_ 11 d1qy7a_ 12 c2j9dG_ 13 c3mhyC_ 14 c4r25A_ 15 c3ncpD_ 16 d1hwua_ 17 c4usiC_ 18 c1xtzA_ 19 c4ozlA_ 20 d2f1fa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99