1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	P	H	Y	R	Q	A	A	A	S	R	L	D	T	H	R	T	Q	K	L	R	S	Q	T	N	G	G	K	D	R	H	Q	L	T	Y	E	Q	F	A	R	M	L	T	L	M	G	P	S	D	L	W	T	V	E	R	A	A	R	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?							?	?	?									?	?	?	?	?	?	?	?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	G	V	S	A	S	R	A	R	A	I	L	S	S	R	H	I	H	R	V	S	G	Y	P	A	Q	A	I	K	A	V	T	L	R	Q	G	A	R	T	D	L	K	T	A	N	H	L	V	P	A	A	Q	A	F	T	M	A	E	T	G
Secondary structure
SS confidence
Disorder														?		?																	?	?			?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	I	G	E	T	E	D	E	R	A	R	L	R	I	F	F	E	F	L	R	G	A	D	E	T	G	T	S	A	L	D	L	I	V	D	E	P	A	L	I	G	E	H	R	F	D	A	L	L	A	A	A	A	E	Y	I	S	A	R
Secondary structure
SS confidence
Disorder						?	?	?	?	?																											?		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	G	R	P	G	P	L	W	S	V	S	I	E	R	F	L	D	T	A	W	W	V	S	D	L	P	S	A	R	A	F	A	A	V	W	T	P	A	P	F	R	R	R	G	I	Y	L	D	R	H	D	L	T	S	D	G	V	C	V	M
Secondary structure
SS confidence
Disorder								?				?	?	?																					?																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	E	P	V	F	N	R	T	E	L	Q	R	A	F	T	A	L	A	A	K	L	E	R	R	G	V	V	G	Q	V	H	V	V	G	G	A	A	M	L	L	A	Y	N	S	R	V	T	T	R	D	I	D	A	L	F	S	T	D	G	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																					?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		M	L	E	A	I	R	E	V	A	D	E	M	G	W	P	R	T	W	L	N	N	Q	A	S	G	Y	V	S	R	T	P	G	E	G	A	P	V	F	D	H	P	F	L	H	V	V	A	T	P	A	Q	H	L	L	A	M	K	V	V	A
Secondary structure
SS confidence
Disorder													?	?	?			?						?		?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.
Sequence		A	R	G	V	R	D	G	E	D	I	R	L	L	L	D	R	L	R	I	T	S	A	A	G	V	W	E	I	V	A	R	Y	F	P	A	E	T	I	T	D	R	S	R	L	L	V	E	D	L	L	N	Q
Secondary structure
SS confidence
Disorder			?	?	?		?																																													?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 60%) Beta strand ( 6%)

Rank Aligned region

PDB 5uvd chain A Region: 245 - 377 Aligned: 127 Modelled: 133 Confidence: 99.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:nucleotidyltransferase-like protein; PDBTitle: crystal structure of an antigenic nucleotidyltransferase-like protein2 from paracoccidioides brasiliensis Phyre2 PDB 4e8i chain A Region: 244 - 375 Aligned: 125 Modelled: 132 Confidence: 98.1% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:lincosamide resistance protein; PDBTitle: crystal structure of lincosamide antibiotic adenylyltransferase lina,2 apo Phyre2 PDB 4ok0 chain B Region: 248 - 393 Aligned: 141 Modelled: 146 Confidence: 97.6% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:putative; PDBTitle: crystal structure of putative nucleotidyltransferase from h. pylori Phyre2 PDB 4wqk chain A Region: 251 - 378 Aligned: 125 Modelled: 128 Confidence: 95.2% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:2''-aminoglycoside nucleotidyltransferase; PDBTitle: crystal structure of aminoglycoside nucleotidylyltransferase ant(2")-2 ia, apo form Phyre2 PDB 3h37 chain B Region: 249 - 307 Aligned: 55 Modelled: 59 Confidence: 78.5% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:trna nucleotidyl transferase-related protein; PDBTitle: the structure of cca-adding enzyme apo form i Phyre2 PDB 1ccw chain A Region: 251 - 314 Aligned: 64 Modelled: 64 Confidence: 73.0% Identity: 17% Fold: Flavodoxin-like Superfamily: Cobalamin (vitamin B12)-binding domain Family: Cobalamin (vitamin B12)-binding domain Phyre2 PDB 1miw chain A domain 2 Region: 249 - 300 Aligned: 47 Modelled: 52 Confidence: 68.3% Identity: 26% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Poly A polymerase head domain-like Phyre2 PDB 1ou5 chain A domain 2 Region: 247 - 307 Aligned: 57 Modelled: 61 Confidence: 65.8% Identity: 19% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Poly A polymerase head domain-like Phyre2 PDB 1ig3 chain A domain 2 Region: 232 - 275 Aligned: 44 Modelled: 44 Confidence: 62.6% Identity: 20% Fold: Thiamin pyrophosphokinase, catalytic domain Superfamily: Thiamin pyrophosphokinase, catalytic domain Family: Thiamin pyrophosphokinase, catalytic domain Phyre2 PDB 2yn2 chain A Region: 222 - 315 Aligned: 70 Modelled: 71 Confidence: 62.3% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein ynl108c; PDBTitle: huf protein - paralogue of the tau55 histidine phosphatase domain Phyre2 PDB 2yn0 chain A Region: 222 - 315 Aligned: 70 Modelled: 71 Confidence: 61.8% Identity: 30% PDB header:transcription Chain: A: PDB Molecule:transcription factor tau 55 kda subunit; PDBTitle: tau55 histidine phosphatase domain Phyre2 PDB 4oi6 chain A Region: 226 - 319 Aligned: 69 Modelled: 76 Confidence: 59.4% Identity: 26% PDB header:metal binding protein Chain: A: PDB Molecule:nickel responsive protein; PDBTitle: crystal structure analysis of nickel-bound form sco4226 from2 streptomyces coelicolor a3(2) Phyre2 PDB 1miy chain B Region: 249 - 300 Aligned: 47 Modelled: 52 Confidence: 55.5% Identity: 26% PDB header:translation, transferase Chain: B: PDB Molecule:trna cca-adding enzyme; PDBTitle: crystal structure of bacillus stearothermophilus cca-adding enzyme in2 complex with ctp Phyre2 PDB 2f17 chain A Region: 234 - 275 Aligned: 42 Modelled: 42 Confidence: 54.4% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:thiamin pyrophosphokinase 1; PDBTitle: mouse thiamin pyrophosphokinase in a ternary complex with2 pyrithiamin pyrophosphate and amp at 2.5 angstrom Phyre2 PDB 1xrs chain B Region: 252 - 313 Aligned: 59 Modelled: 62 Confidence: 49.6% Identity: 20% PDB header:isomerase Chain: B: PDB Molecule:d-lysine 5,6-aminomutase beta subunit; PDBTitle: crystal structure of lysine 5,6-aminomutase in complex with plp,2 cobalamin, and 5'-deoxyadenosine Phyre2 PDB 2bcq chain A domain 3 Region: 247 - 380 Aligned: 128 Modelled: 134 Confidence: 49.4% Identity: 13% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: DNA polymerase beta-like Phyre2 PDB 4q6t chain A Region: 211 - 272 Aligned: 59 Modelled: 62 Confidence: 49.1% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:glycosyl hydrolase, family 18; PDBTitle: the crystal structure of a class v chitininase from pseudomonas2 fluorescens pf-5 Phyre2 PDB 2hro chain A Region: 331 - 393 Aligned: 61 Modelled: 63 Confidence: 47.5% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus Phyre2 PDB 3k35 chain D Region: 236 - 279 Aligned: 41 Modelled: 44 Confidence: 45.9% Identity: 29% PDB header:hydrolase Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6 Phyre2 PDB 2qm3 chain A Region: 161 - 363 Aligned: 142 Modelled: 158 Confidence: 44.8% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:predicted methyltransferase; PDBTitle: crystal structure of a predicted methyltransferase from pyrococcus2 furiosus Phyre2 1 c5uvdA_ 2 c4e8iA_ 3 c4ok0B_ 4 c4wqkA_ 5 c3h37B_ 6 d1ccwa_ 7 d1miwa2 8 d1ou5a2 9 d1ig3a2 10 c2yn2A_ 11 c2yn0A_ 12 c4oi6A_ 13 c1miyB_ 14 c2f17A_ 15 c1xrsB_ 16 d2bcqa3 17 c4q6tA_ 18 c2hroA_ 19 c3k35D_ 20 c2qm3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99