1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	G	L	F	G	L	L	D	H	V	A	V	L	A	R	L	A	A	A	S	I	D	D	I	G	A	A	A	G	R	A	T	A	K	A	A	G	V	V	I	D	D	T	A	V	T	P	Q	Y	V	H	R	I	T	A	E	R	E
Secondary structure
SS confidence
Disorder		?	?	?	?																												?	?	?	?																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	P	I	I	K	R	I	A	I	G	S	V	R	N	K	L	L	L	I	L	P	G	A	L	L	L	S	Q	L	V	P	W	L	L	T	P	L	L	M	L	G	A	T	Y	L	C	Y	E	G	A	E	K	V	C	G	V	I	G	G	R
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	H	D	A	A	P	Q	V	A	E	R	E	L	V	A	G	A	I	R	T	D	F	I	L	S	A	E	I	M	V	I	A	L	N	E	V	A	D	Q	P	F	V	P	R	L	I	V	L	V	I	V	A	L	V	I	T	A	A	V	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?																															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	V	V	A	V	I	V	Q	M	D	D	V	G	L	R	L	T	Q	T	A	S	R	F	G	Q	R	I	G	G	G	L	V	A	G	M	P	K	L	L	S	A	L	S	A	V	G	M	G	A	M	L	W	V	G	G	H	I	V	L	V
Secondary structure
SS confidence
Disorder																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	S	D	H	L	G	W	H	A	P	Y	R	L	V	H	H	L	D	D	H	L	V	G	S	A	G	G	A	L	T	W	L	V	S	T	A	A	C	A	A	T	G	L	V	I	G	I	V	V	V	A	L	V	H	L	V	C	F	R	P
Secondary structure
SS confidence
Disorder																								?	?	?	?																														?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		P	R	S	R	S	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 42%) (View membrane topology prediction)

Rank Aligned region

PDB 5wwo chain B Region: 55 - 139 Aligned: 60 Modelled: 60 Confidence: 40.8% Identity: 27% PDB header:rna binding protein Chain: B: PDB Molecule:essential nuclear protein 1; PDBTitle: crystal structure of enp1 Phyre2 PDB 2end chain A Region: 59 - 75 Aligned: 17 Modelled: 17 Confidence: 37.0% Identity: 35% Fold: T4 endonuclease V Superfamily: T4 endonuclease V Family: T4 endonuclease V Phyre2 PDB 2l9u chain B Region: 93 - 109 Aligned: 17 Modelled: 17 Confidence: 36.5% Identity: 41% PDB header:membrane protein Chain: B: PDB Molecule:receptor tyrosine-protein kinase erbb-3; PDBTitle: spatial structure of dimeric erbb3 transmembrane domain Phyre2 PDB 2l9u chain A Region: 93 - 109 Aligned: 17 Modelled: 17 Confidence: 36.5% Identity: 41% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-3; PDBTitle: spatial structure of dimeric erbb3 transmembrane domain Phyre2 PDB 4cv5 chain D Region: 141 - 220 Aligned: 66 Modelled: 80 Confidence: 27.3% Identity: 21% PDB header:cell cycle Chain: D: PDB Molecule:protein caf40; PDBTitle: yeast not1 cn9bd-caf40 complex Phyre2 PDB 5doq chain C Region: 211 - 234 Aligned: 21 Modelled: 21 Confidence: 21.9% Identity: 48% PDB header:oxidoreductase Chain: C: PDB Molecule:putative membrane protein; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 5ir6 chain C Region: 211 - 234 Aligned: 21 Modelled: 24 Confidence: 21.9% Identity: 48% PDB header:oxidoreductase Chain: C: PDB Molecule:putative membrane protein; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 5tvo chain B Region: 106 - 129 Aligned: 24 Modelled: 24 Confidence: 20.2% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:s-adenosylmethionine decarboxylase proenzyme; PDBTitle: crystal structure of trypanosoma brucei adometdc-delta26 monomer Phyre2 PDB 5tvf chain C Region: 107 - 126 Aligned: 20 Modelled: 20 Confidence: 18.5% Identity: 30% PDB header:lyase Chain: C: PDB Molecule:s-adenosylmethionine decarboxylase beta chain; PDBTitle: crystal structure of trypanosoma brucei adometdc/prozyme heterodimer2 in complex with inhibitor cgp 40215 Phyre2 PDB 2voy chain B Region: 57 - 92 Aligned: 36 Modelled: 36 Confidence: 16.5% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium atpase 1; PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 4r0c chain B Region: 89 - 291 Aligned: 180 Modelled: 192 Confidence: 16.4% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 1nex chain A domain 2 Region: 111 - 126 Aligned: 16 Modelled: 16 Confidence: 16.2% Identity: 19% Fold: POZ domain Superfamily: POZ domain Family: BTB/POZ domain Phyre2 PDB 4gl6 chain B Region: 106 - 128 Aligned: 23 Modelled: 23 Confidence: 15.6% Identity: 17% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a duf5037 family protein (rumgna_01148) from2 ruminococcus gnavus atcc 29149 at 2.55 a resolution Phyre2 PDB 1i7m chain D Region: 107 - 115 Aligned: 9 Modelled: 9 Confidence: 15.0% Identity: 44% PDB header:lyase Chain: D: PDB Molecule:s-adenosylmethionine decarboxylase beta chain; PDBTitle: human s-adenosylmethionine decarboxylase with covalently bound2 pyruvoyl group and complexed with 4-amidinoindan-1-one-2'-3 amidinohydrazone Phyre2 PDB 6g4w chain W Region: 56 - 139 Aligned: 59 Modelled: 59 Confidence: 14.0% Identity: 24% PDB header:ribosome Chain: W: PDB Molecule:40s ribosomal protein s15a; PDBTitle: cryo-em structure of a late human pre-40s ribosomal subunit - state a Phyre2 PDB 4zr0 chain A Region: 76 - 108 Aligned: 33 Modelled: 33 Confidence: 13.5% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ceramide very long chain fatty acid hydroxylase scs7; PDBTitle: full length scs7p (only hydroxylase domain visible) Phyre2 PDB 1w8x chain P Region: 230 - 239 Aligned: 10 Modelled: 10 Confidence: 12.5% Identity: 60% PDB header:virus Chain: P: PDB Molecule:protein p16; PDBTitle: structural analysis of prd1 Phyre2 PDB 2c9w chain C domain 1 Region: 111 - 147 Aligned: 34 Modelled: 37 Confidence: 10.4% Identity: 18% Fold: POZ domain Superfamily: POZ domain Family: BTB/POZ domain Phyre2 PDB 5j6v chain A Region: 64 - 74 Aligned: 11 Modelled: 11 Confidence: 9.9% Identity: 36% PDB header:antimicrobial protein Chain: A: PDB Molecule:hylin-d; PDBTitle: nmr structures of hylin-a1 analogs: hylin-d Phyre2 PDB 5j6w chain A Region: 64 - 74 Aligned: 11 Modelled: 11 Confidence: 9.5% Identity: 36% PDB header:antimicrobial protein Chain: A: PDB Molecule:hylin-k; PDBTitle: nmr structures of hylin-a1 analogs: hylin-k Phyre2 1 c5wwoB_ 2 d2enda_ 3 c2l9uB_ 4 c2l9uA_ 5 c4cv5D_ 6 c5doqC_ 7 c5ir6C_ 8 c5tvoB_ 9 c5tvfC_ 10 c2voyB_ 11 c4r0cB_ 12 d1nexa2 13 c4gl6B_ 14 c1i7mD_ 15 c6g4ww_ 16 c4zr0A_ 17 c1w8xP_ 18 d2c9wc1 19 c5j6vA_ 20 c5j6wA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43