1

.

.

.

.

.

.

.

.

10

.

.

.

.

.

.

.

.

.

20

.

.

.

.

.

.

.

.

.

30

.

.

.

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

Sequence

M

T

P

N

A

A

S

T

G

D

S

A

K

N

T

I

T

G

C

C

L

I

T

A

R

A

L

V

A

R

T

R

S

I

S

L

P

G

M

P

F

R

M

P

A

D

Y

H

N

A

S

S

D

E

P

T

N

R

H

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

.

.

.

.

.

90

.

.

.

.

.

.

.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

.

.

120

Sequence

W

P

A

P

A

R

C

C

R

H

E

W

R

T

M

R

R

T

N

A

C

D

R

R

R

F

G

L

S

L

T

I

H

E

D

A

C

R

I

I

S

V

V

P

V

V

L

E

V

R

R

A

E

P

A

H

P

A

T

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

130

.

.

.

.

.

.

.

.

.

140

.

.

.

.

.

.

Sequence

Y

P

E

P

L

A

R

C

S

R

S

P

G

L

N

E

S

S

H

M

S

G

R

I

P

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 45%) Alpha helix ( 41%) Beta strand ( 8%)

Rank Aligned region

PDB 6s3f chain B Region: 68 - 83 Aligned: 16 Modelled: 16 Confidence: 25.1% Identity: 50% PDB header:antifungal protein Chain: B: PDB Molecule:2s albumin; PDBTitle: moringa seed protein mo-cbp3-4 Phyre2 PDB 6gcs chain K Region: 44 - 91 Aligned: 47 Modelled: 48 Confidence: 20.3% Identity: 28% PDB header:oxidoreductase Chain: K: PDB Molecule:psst subunit (nukm); PDBTitle: cryo-em structure of respiratory complex i from yarrowia lipolytica Phyre2 PDB 5wcv chain A Region: 13 - 25 Aligned: 13 Modelled: 13 Confidence: 15.3% Identity: 69% PDB header:toxin Chain: A: PDB Molecule:shk homolog ask132958; PDBTitle: ask132958: a minimal homologue of shk identified in the transcriptome2 of anemonia sulcata Phyre2 PDB 2ich chain A domain 1 Region: 36 - 92 Aligned: 41 Modelled: 42 Confidence: 10.4% Identity: 22% Fold: AttH-like Superfamily: AttH-like Family: AttH-like Phyre2 PDB 2juf chain A Region: 37 - 54 Aligned: 18 Modelled: 18 Confidence: 10.2% Identity: 44% PDB header:gene regulation Chain: A: PDB Molecule:p53-associated parkin-like cytoplasmic protein; PDBTitle: nmr solution structure of parc cph domain. nesg target2 hr3443b/sgc-toronto Phyre2 PDB 2eje chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 8.4% Identity: 36% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i; PDBTitle: solution structure of rsgi ruh-071, a gtf2i domain in human2 cdna Phyre2 PDB 2dn5 chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 8.0% Identity: 45% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i repeat domain- PDBTitle: solution structure of rsgi ruh-057, a gtf2i domain in human2 cdna Phyre2 PDB 2dzr chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 7.9% Identity: 55% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i repeat domain- PDBTitle: solution structure of rsgi ruh-067, a gtf2i domain in human2 cdna Phyre2 PDB 2jng chain A domain 1 Region: 37 - 54 Aligned: 18 Modelled: 18 Confidence: 7.8% Identity: 44% Fold: SH3-like barrel Superfamily: Tudor/PWWP/MBT Family: CPH domain Phyre2 PDB 1q60 chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 7.8% Identity: 45% Fold: GTF2I-like repeat Superfamily: GTF2I-like repeat Family: GTF2I-like repeat Phyre2 PDB 2dn4 chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 7.8% Identity: 55% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i; PDBTitle: solution structure of rsgi ruh-060, a gtf2i domain in human2 cdna Phyre2 PDB 2ed2 chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 7.4% Identity: 45% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i; PDBTitle: solution structure of rsgi ruh-069, a gtf2i domain in human2 cdna Phyre2 PDB 2d99 chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 7.4% Identity: 55% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i repeat domain- PDBTitle: solution structure of rsgi ruh-048, a gtf2i domain in human2 cdna Phyre2 PDB 2dzq chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 7.0% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:general transcription factor ii-i repeat domain- PDBTitle: solution structure of rsgi ruh-066, a gtf2i domain in human2 cdna Phyre2 PDB 2e3l chain A Region: 37 - 47 Aligned: 11 Modelled: 11 Confidence: 6.8% Identity: 36% PDB header:transcription Chain: A: PDB Molecule:transcription factor gtf2ird2 beta; PDBTitle: solution structure of rsgi ruh-068, a gtf2i domain in human2 cdna Phyre2 PDB 2mfa chain A Region: 38 - 42 Aligned: 5 Modelled: 5 Confidence: 6.1% Identity: 100% PDB header:toxin Chain: A: PDB Molecule:mambalgin-2; PDBTitle: mambalgin-2 Phyre2 PDB 1ddw chain A Region: 70 - 108 Aligned: 34 Modelled: 39 Confidence: 5.8% Identity: 18% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Enabled/VASP homology 1 domain (EVH1 domain) Phyre2 PDB 4yhw chain A Region: 13 - 23 Aligned: 11 Modelled: 11 Confidence: 5.2% Identity: 27% PDB header:splicing Chain: A: PDB Molecule:u4/u6 small nuclear ribonucleoprotein prp3; PDBTitle: yeast prp3 (296-469) in complex with fragment of u4/u6 di-snrna Phyre2 PDB 3e5a chain B Region: 41 - 61 Aligned: 21 Modelled: 21 Confidence: 5.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:targeting protein for xklp2; PDBTitle: crystal structure of aurora a in complex with vx-680 and tpx2 Phyre2 1 c6s3fB_ 2 c6gcsK_ 3 c5wcvA_ 4 d2icha1 5 c2jufA_ 6 c2ejeA_ 7 c2dn5A_ 8 c2dzrA_ 9 d2jnga1 10 d1q60a_ 11 c2dn4A_ 12 c2ed2A_ 13 c2d99A_ 14 c2dzqA_ 15 c2e3lA_ 16 c2mfaA_ 17 d1ddwa_ 18 c4yhwA_ 19 c3e5aB_