1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	N	T	D	R	P	A	L	P	H	K	R	A	V	P	P	S	R	A	D	S	G	P	R	R	R	R	T	K	L	L	D	A	V	A	G	F	G	V	T	L	G	S	M	F	K	K	T	V	T	E	E	Y	P	E	R	P	G	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	A	R	Y	H	G	R	H	Q	L	N	R	Y	P	D	G	L	E	K	C	I	G	C	E	L	C	A	W	A	C	P	A	D	A	I	Y	V	E	G	A	D	N	T	E	E	E	R	F	S	P	G	E	R	Y	G	R	V	Y	Q
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	N	Y	L	R	C	I	G	C	G	L	C	I	E	A	C	P	T	R	A	L	T	M	T	Y	D	Y	E	L	A	D	D	N	R	A	D	L	I	Y	E	K	D	R	L	L	A	P	L	L	P	E	M	A	A	P	P	H	P	R	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.
Sequence		P	G	A	T	D	K	D	Y	Y	L	G	N	V	T	A	E	G	L	R	G	V	R	E	S	Q	T	T	G	D	S	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?	?			?	?				?					?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 24%) Beta strand ( 15%)

Rank Aligned region

PDB 6gcs chain I Region: 11 - 166 Aligned: 150 Modelled: 156 Confidence: 100.0% Identity: 37% PDB header:oxidoreductase Chain: I: PDB Molecule:tyky subunit (nuim); PDBTitle: cryo-em structure of respiratory complex i from yarrowia lipolytica Phyre2 PDB 5lc5 chain I Region: 30 - 166 Aligned: 131 Modelled: 137 Confidence: 100.0% Identity: 38% PDB header:oxidoreductase Chain: I: PDB Molecule:nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, PDBTitle: structure of mammalian respiratory complex i, class2 Phyre2 PDB 4hea chain O Region: 31 - 208 Aligned: 178 Modelled: 178 Confidence: 100.0% Identity: 46% PDB header:oxidoreductase Chain: O: PDB Molecule:nadh-quinone oxidoreductase subunit 9; PDBTitle: crystal structure of the entire respiratory complex i from thermus2 thermophilus Phyre2 PDB 6hum chain I Region: 30 - 175 Aligned: 136 Modelled: 146 Confidence: 100.0% Identity: 30% PDB header:proton transport Chain: I: PDB Molecule:nad(p)h-quinone oxidoreductase subunit i; PDBTitle: structure of the photosynthetic complex i from thermosynechococcus2 elongatus Phyre2 PDB 2fug chain 9 domain 1 Region: 54 - 172 Aligned: 119 Modelled: 119 Confidence: 100.0% Identity: 56% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 2fug chain G Region: 54 - 172 Aligned: 119 Modelled: 119 Confidence: 100.0% Identity: 56% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase chain 9; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus Phyre2 PDB 6cfw chain N Region: 38 - 159 Aligned: 103 Modelled: 108 Confidence: 99.9% Identity: 31% PDB header:membrane protein Chain: N: PDB Molecule:nadh-plastoquinone oxidoreductase subunit; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 5c4i chain B Region: 67 - 151 Aligned: 69 Modelled: 69 Confidence: 99.6% Identity: 35% PDB header:oxidoreductase Chain: B: PDB Molecule:oxalate oxidoreductase subunit delta; PDBTitle: structure of an oxalate oxidoreductase Phyre2 PDB 5odh chain G Region: 77 - 168 Aligned: 67 Modelled: 92 Confidence: 99.6% Identity: 33% PDB header:oxidoreductase Chain: G: PDB Molecule:heterodisulfide reductase, subunit a; PDBTitle: heterodisulfide reductase / [nife]-hydrogenase complex from2 methanothermococcus thermolithotrophicus soaked with heterodisulfide3 for 3.5 minutes Phyre2 PDB 2fug chain 3 domain 4 Region: 14 - 146 Aligned: 116 Modelled: 130 Confidence: 99.5% Identity: 21% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 6cip chain D Region: 66 - 159 Aligned: 93 Modelled: 94 Confidence: 99.5% Identity: 30% PDB header:oxidoreductase Chain: D: PDB Molecule:pyruvate-ferredoxin oxidoreductase; PDBTitle: pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with2 acetyl-tpp bound Phyre2 PDB 2gmh chain A Region: 79 - 148 Aligned: 60 Modelled: 60 Confidence: 99.5% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:electron transfer flavoprotein-ubiquinone PDBTitle: structure of porcine electron transfer flavoprotein-2 ubiquinone oxidoreductase in complexed with ubiquinone Phyre2 PDB 1jb0 chain C Region: 79 - 159 Aligned: 73 Modelled: 81 Confidence: 99.5% Identity: 29% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: 7-Fe ferredoxin Phyre2 PDB 5t5i chain N Region: 54 - 146 Aligned: 80 Modelled: 93 Confidence: 99.4% Identity: 26% PDB header:oxidoreductase Chain: N: PDB Molecule:tungsten formylmethanofuran dehydrogenase subunit fwdf; PDBTitle: tungsten-containing formylmethanofuran dehydrogenase from2 methanothermobacter wolfeii, orthorhombic form at 1.9 a Phyre2 PDB 1xer chain A Region: 54 - 145 Aligned: 80 Modelled: 92 Confidence: 99.4% Identity: 21% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Archaeal ferredoxins Phyre2 PDB 1c4c chain A Region: 1 - 182 Aligned: 164 Modelled: 182 Confidence: 99.4% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:protein (fe-only hydrogenase); PDBTitle: binding of exogenously added carbon monoxide at the active2 site of the fe-only hydrogenase (cpi) from clostridium3 pasteurianum Phyre2 PDB 2c3y chain A Region: 66 - 159 Aligned: 93 Modelled: 94 Confidence: 99.4% Identity: 35% PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate-ferredoxin oxidoreductase; PDBTitle: crystal structure of the radical form of2 pyruvate:ferredoxin oxidoreductase from desulfovibrio3 africanus Phyre2 PDB 5lc5 chain G Region: 1 - 146 Aligned: 124 Modelled: 142 Confidence: 99.4% Identity: 21% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-ubiquinone oxidoreductase 75 kda subunit, PDBTitle: structure of mammalian respiratory complex i, class2 Phyre2 PDB 5lnk chain 3 Region: 1 - 142 Aligned: 119 Modelled: 133 Confidence: 99.4% Identity: 22% PDB header:oxidoreductase Chain: 3: PDB Molecule:mitochondrial complex i, 75 kda subunit; PDBTitle: entire ovine respiratory complex i Phyre2 PDB 7fd1 chain A Region: 79 - 196 Aligned: 98 Modelled: 102 Confidence: 99.4% Identity: 23% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: 7-Fe ferredoxin Phyre2 1 c6gcsI_ 2 c5lc5I_ 3 c4heaO_ 4 c6humI_ 5 d2fug91 6 c2fugG_ 7 c6cfwN_ 8 c5c4iB_ 9 c5odhG_ 10 d2fug34 11 c6cipD_ 12 c2gmhA_ 13 d1jb0c_ 14 c5t5iN_ 15 d1xera_ 16 c1c4cA_ 17 c2c3yA_ 18 c5lc5G_ 19 c5lnk3_ 20 d7fd1a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109