1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	S	T	D	N	R	A	E	L	G	D	I	L	T	D	I	G	D	Y	L	D	D	N	P	P	A	L	S	L	P	P	A	A	Y	T	S	S	E	L	W	Q	L	E	R	E	R	I	F	N	R	S	W	M	L	V	A	H	V	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?	?	?							?				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	V	A	K	T	G	D	Y	V	T	V	S	V	A	G	E	P	V	M	V	V	R	D	V	D	G	Q	L	H	A	L	S	P	I	C	R	H	R	L	M	L	M	V	E	P	G	A	G	R	I	D	T	L	T	C	Q	Y	H	L	W
Secondary structure
SS confidence
Disorder																																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	Y	G	L	D	G	R	L	R	G	A	P	H	M	A	A	N	L	D	F	N	R	R	E	C	R	L	P	Q	F	A	V	A	T	W	N	G	L	V	W	I	N	L	D	A	D	A	E	P	I	A	A	H	L	D	L	T	D	D	E
Secondary structure
SS confidence
Disorder																	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	A	G	Y	R	L	G	E	M	V	Q	V	E	S	W	S	H	E	W	R	A	N	W	K	V	A	A	E	N	G	H	E	N	Y	H	V	L	G	L	H	R	Q	T	L	E	P	F	V	P	G	G	G	D	L	D	V	R	Q	Y	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	W	A	L	R	L	R	V	P	F	T	V	P	V	E	A	K	S	L	Q	L	N	E	V	Q	K	S	N	L	V	V	L	W	T	F	P	N	S	A	L	A	I	A	G	E	R	V	V	W	F	G	F	I	P	Q	S	I	D	R	V
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	V	L	G	G	V	L	T	T	P	E	L	A	A	D	A	A	A	T	A	Q	T	S	Q	F	V	M	A	M	I	N	D	E	D	R	L	G	L	E	A	V	Q	V	G	A	G	S	R	F	A	E	R	G	H	L	S	S	K	E	W
Secondary structure
SS confidence
Disorder																																															?	?		?	?	?		?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.
Sequence		P	G	M	L	A	F	Y	R	N	L	A	M	A	L	V	G	D	H	P	G	A	S
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 30%) Beta strand ( 27%)

Rank Aligned region

PDB 3n0q chain A Region: 16 - 377 Aligned: 360 Modelled: 362 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:putative aromatic-ring hydroxylating dioxygenase; PDBTitle: crystal structure of a putative aromatic-ring hydroxylating2 dioxygenase (tm1040_3219) from silicibacter sp. tm1040 at 1.80 a3 resolution Phyre2 PDB 3vca chain A Region: 17 - 377 Aligned: 359 Modelled: 361 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:ring-hydroxylating dioxygenase; PDBTitle: quaternary ammonium oxidative demethylation: x-ray crystallographic,2 resonance raman and uv-visible spectroscopic analysis of a rieske-3 type demethylase Phyre2 PDB 2b1x chain E Region: 1 - 379 Aligned: 372 Modelled: 379 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: E: PDB Molecule:naphthalene dioxygenase large subunit; PDBTitle: crystal structure of naphthalene 1,2-dioxygenase from rhodococcus sp. Phyre2 PDB 1ulj chain A Region: 15 - 377 Aligned: 359 Modelled: 363 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:biphenyl dioxygenase large subunit; PDBTitle: biphenyl dioxygenase (bpha1a2) in complex with the substrate Phyre2 PDB 1wql chain A Region: 15 - 377 Aligned: 359 Modelled: 363 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:iron-sulfur protein large subunit of cumene dioxygenase; PDBTitle: cumene dioxygenase (cuma1a2) from pseudomonas fluorescens ip01 Phyre2 PDB 2hmn chain A Region: 23 - 377 Aligned: 353 Modelled: 355 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:naphthalene 1,2-dioxygenase alpha subunit; PDBTitle: crystal structure of the naphthalene 1,2-dioxygenase f352v2 mutant bound to anthracene. Phyre2 PDB 2gbx chain E Region: 23 - 377 Aligned: 353 Modelled: 355 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: E: PDB Molecule:biphenyl 2,3-dioxygenase alpha subunit; PDBTitle: crystal structure of biphenyl 2,3-dioxygenase from sphingomonas2 yanoikuyae b1 bound to biphenyl Phyre2 PDB 3gte chain B Region: 47 - 377 Aligned: 319 Modelled: 331 Confidence: 100.0% Identity: 14% PDB header:electron transport, oxidoreductase Chain: B: PDB Molecule:ddmc; PDBTitle: crystal structure of dicamba monooxygenase with non-heme iron Phyre2 PDB 3gkq chain B Region: 43 - 379 Aligned: 327 Modelled: 337 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole 1,9a-dioxygenase; PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from novosphingobium2 sp. ka1 Phyre2 PDB 2zyl chain A Region: 48 - 375 Aligned: 307 Modelled: 327 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:possible oxidoreductase; PDBTitle: crystal structure of 3-ketosteroid-9-alpha-hydroxylase2 (ksha) from m. tuberculosis Phyre2 PDB 3gcf chain C Region: 43 - 376 Aligned: 325 Modelled: 333 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: C: PDB Molecule:terminal oxygenase component of carbazole 1,9a- PDBTitle: terminal oxygenase of carbazole 1,9a-dioxygenase from2 nocardioides aromaticivorans ic177 Phyre2 PDB 4qdf chain A Region: 49 - 381 Aligned: 313 Modelled: 333 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:3-ketosteroid 9alpha-hydroxylase oxygenase; PDBTitle: crystal structure of apo ksha5 and ksha1 in complex with 1,4-30q-coa2 from r. rhodochrous Phyre2 PDB 4qdf chain B Region: 48 - 382 Aligned: 306 Modelled: 321 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: B: PDB Molecule:3-ketosteroid 9alpha-hydroxylase oxygenase; PDBTitle: crystal structure of apo ksha5 and ksha1 in complex with 1,4-30q-coa2 from r. rhodochrous Phyre2 PDB 2de7 chain B Region: 44 - 381 Aligned: 327 Modelled: 338 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:terminal oxygenase component of carbazole; PDBTitle: the substrate-bound complex between oxygenase and2 ferredoxin in carbazole 1,9a-dioxygenase Phyre2 PDB 1z01 chain D Region: 37 - 381 Aligned: 340 Modelled: 345 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: D: PDB Molecule:2-oxo-1,2-dihydroquinoline 8-monooxygenase, oxygenase PDBTitle: 2-oxoquinoline 8-monooxygenase component: active site modulation by2 rieske-[2fe-2s] center oxidation/reduction Phyre2 PDB 2b1x chain A domain 1 Region: 1 - 166 Aligned: 159 Modelled: 166 Confidence: 100.0% Identity: 30% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 1wql chain A domain 1 Region: 15 - 166 Aligned: 150 Modelled: 152 Confidence: 100.0% Identity: 32% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 1uli chain A domain 1 Region: 15 - 166 Aligned: 150 Modelled: 152 Confidence: 100.0% Identity: 37% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 2bmo chain A domain 1 Region: 23 - 165 Aligned: 143 Modelled: 143 Confidence: 100.0% Identity: 28% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 PDB 1o7n chain A domain 1 Region: 24 - 165 Aligned: 142 Modelled: 142 Confidence: 100.0% Identity: 30% Fold: ISP domain Superfamily: ISP domain Family: Ring hydroxylating alpha subunit ISP domain Phyre2 1 c3n0qA_ 2 c3vcaA_ 3 c2b1xE_ 4 c1uljA_ 5 c1wqlA_ 6 c2hmnA_ 7 c2gbxE_ 8 c3gteB_ 9 c3gkqB_ 10 c2zylA_ 11 c3gcfC_ 12 c4qdfA_ 13 c4qdfB_ 14 c2de7B_ 15 c1z01D_ 16 d2b1xa1 17 d1wqla1 18 d1ulia1 19 d2bmoa1 20 d1o7na1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99