1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	Q	M	L	G	P	L	D	E	Y	P	L	H	Q	L	P	Q	P	I	A	W	P	G	S	S	D	R	N	F	Y	D	R	S	Y	F	N	A	H	D	R	T	G	N	I	F	L	I	T	G	I	G	Y	Y	P	N	L	G	V	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	A	F	V	L	I	R	R	A	D	I	Q	T	A	V	H	L	S	D	A	I	D	S	D	R	L	H	Q	H	V	N	G	Y	R	V	E	V	V	E	P	L	R	K	L	R	I	V	L	D	E	T	E	G	V	A	A	D	L	T	W
Secondary structure
SS confidence
Disorder																						?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	G	L	F	D	V	V	Q	E	Q	P	H	V	L	R	S	G	N	R	V	T	L	D	A	Q	R	F	A	Q	L	G	T	W	S	G	R	I	V	V	D	G	E	R	I	A	V	D	P	A	T	W	L	G	S	R	D	R	S	W	G
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	R	P	V	G	E	P	E	P	A	G	R	P	A	D	P	P	F	E	G	M	W	W	L	Y	V	P	L	A	F	D	D	F	A	V	V	L	I	I	Q	E	E	P	D	G	F	R	S	L	N	D	C	T	R	I	W	R	D	G	H
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	E	Q	L	G	W	P	R	V	R	I	H	Y	R	S	G	T	R	I	P	T	G	A	T	I	E	A	S	T	P	D	G	A	P	V	H	F	D	V	E	S	K	L	A	V	P	T	H	V	G	G	G	Y	G	G	D	S	D	W	S
Secondary structure
SS confidence
Disorder																																												?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		H	G	M	W	K	G	E	K	F	V	E	R	R	T	Y	D	M	T	D	P	T	I	I	A	R	A	G	F	G	V	I	D	H	V	G	R	A	L	C	R	D	G	D	G	N	P	V	Q	G	W	G	L	F	E	H	G	A	L	G	R
Secondary structure
SS confidence
Disorder		?		?																																							?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.
Sequence		H	D	P	S	G	F	A	D	W	S	T	L	A	P
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 1%) Beta strand ( 52%)

Rank Aligned region

PDB 2ich chain A domain 1 Region: 17 - 311 Aligned: 274 Modelled: 292 Confidence: 100.0% Identity: 18% Fold: AttH-like Superfamily: AttH-like Family: AttH-like Phyre2 PDB 1cjy chain B Region: 3 - 45 Aligned: 43 Modelled: 43 Confidence: 62.3% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:protein (cytosolic phospholipase a2); PDBTitle: human cytosolic phospholipase a2 Phyre2 PDB 2v5i chain A Region: 7 - 19 Aligned: 13 Modelled: 13 Confidence: 45.0% Identity: 62% PDB header:viral protein Chain: A: PDB Molecule:salmonella typhimurium db7155 bacteriophage det7 tailspike; PDBTitle: structure of the receptor-binding protein of bacteriophage det7: a2 podoviral tailspike in a myovirus Phyre2 PDB 1tyw chain A Region: 7 - 19 Aligned: 13 Modelled: 13 Confidence: 38.4% Identity: 62% Fold: Single-stranded right-handed beta-helix Superfamily: Pectin lyase-like Family: P22 tailspike protein Phyre2 PDB 3riq chain A Region: 7 - 18 Aligned: 12 Modelled: 12 Confidence: 37.0% Identity: 58% PDB header:viral protein Chain: A: PDB Molecule:tailspike protein; PDBTitle: siphovirus 9na tailspike receptor binding domain Phyre2 PDB 5lc0 chain B Region: 230 - 305 Aligned: 67 Modelled: 75 Confidence: 34.9% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:ns2b-ns3 protease,ns2b-ns3 protease; PDBTitle: crystal structure of zika virus ns2b-ns3 protease in complex with a2 boronate inhibitor Phyre2 PDB 4qsg chain A Region: 353 - 369 Aligned: 17 Modelled: 17 Confidence: 34.4% Identity: 18% PDB header:structural protein Chain: A: PDB Molecule:gas vesicle protein; PDBTitle: crystal structure of gas vesicle protein gvpf from microcystis2 aeruginosa Phyre2 PDB 2xc1 chain A Region: 7 - 19 Aligned: 13 Modelled: 13 Confidence: 30.9% Identity: 62% PDB header:hydrolase Chain: A: PDB Molecule:bifunctional tail protein; PDBTitle: full-length tailspike protein mutant y108w of bacteriophage p22 Phyre2 PDB 1h2i chain G Region: 293 - 354 Aligned: 53 Modelled: 62 Confidence: 21.3% Identity: 23% PDB header:dna binding protein Chain: G: PDB Molecule:dna repair protein rad52 homolog; PDBTitle: human rad52 protein, n-terminal domain Phyre2 PDB 2ea9 chain A domain 1 Region: 1 - 56 Aligned: 45 Modelled: 56 Confidence: 18.7% Identity: 22% Fold: Profilin-like Superfamily: YeeU-like Family: YagB/YeeU/YfjZ-like Phyre2 PDB 2h28 chain A domain 1 Region: 1 - 60 Aligned: 49 Modelled: 58 Confidence: 17.5% Identity: 18% Fold: Profilin-like Superfamily: YeeU-like Family: YagB/YeeU/YfjZ-like Phyre2 PDB 5xf9 chain F Region: 154 - 170 Aligned: 17 Modelled: 17 Confidence: 16.2% Identity: 29% PDB header:oxidoreductase Chain: F: PDB Molecule:nad-reducing hydrogenase; PDBTitle: crystal structure of nad+-reducing [nife]-hydrogenase in the air-2 oxidized state Phyre2 PDB 1kn0 chain A Region: 293 - 354 Aligned: 53 Modelled: 62 Confidence: 15.9% Identity: 23% Fold: dsRBD-like Superfamily: dsRNA-binding domain-like Family: The homologous-pairing domain of Rad52 recombinase Phyre2 PDB 2inw chain A domain 1 Region: 1 - 56 Aligned: 45 Modelled: 56 Confidence: 14.7% Identity: 18% Fold: Profilin-like Superfamily: YeeU-like Family: YagB/YeeU/YfjZ-like Phyre2 PDB 3j6v chain E Region: 298 - 352 Aligned: 55 Modelled: 55 Confidence: 14.3% Identity: 25% PDB header:ribosome Chain: E: PDB Molecule:28s ribosomal protein s5, mitochondrial; PDBTitle: cryo-em structure of the small subunit of the mammalian mitochondrial2 ribosome Phyre2 PDB 5izr chain C Region: 3 - 123 Aligned: 107 Modelled: 121 Confidence: 13.6% Identity: 26% PDB header:hydrolase/hydrolase inhibitor Chain: C: PDB Molecule:cytosolic phospholipase a2 delta; PDBTitle: human givd cytosolic phospholipase a2 in complex with methyl gamma-2 linolenyl fluorophosphonate inhibitor and terbium chloride Phyre2 PDB 4g6t chain B Region: 155 - 168 Aligned: 14 Modelled: 14 Confidence: 12.6% Identity: 36% PDB header:chaperone Chain: B: PDB Molecule:type iii effector hopa1; PDBTitle: structure of the hopa1-scha chaperone-effector complex Phyre2 PDB 4k15 chain A Region: 264 - 304 Aligned: 41 Modelled: 41 Confidence: 8.3% Identity: 20% PDB header:unknown function Chain: A: PDB Molecule:lmo2686 protein; PDBTitle: 2.75 angstrom crystal structure of hypothetical protein lmo2686 from2 listeria monocytogenes egd-e Phyre2 PDB 2z5d chain A Region: 77 - 125 Aligned: 49 Modelled: 49 Confidence: 6.8% Identity: 14% PDB header:ligase Chain: A: PDB Molecule:ubiquitin-conjugating enzyme e2 h; PDBTitle: human ubiquitin-conjugating enzyme e2 h Phyre2 PDB 6c23 chain C Region: 1 - 33 Aligned: 33 Modelled: 33 Confidence: 6.6% Identity: 30% PDB header:gene regulation Chain: C: PDB Molecule:histone-lysine n-methyltransferase ezh2; PDBTitle: cryo-em structure of prc2 bound to cofactors aebp2 and jarid2 in the2 compact active state Phyre2 1 d2icha1 2 c1cjyB_ 3 c2v5iA_ 4 d1tywa_ 5 c3riqA_ 6 c5lc0B_ 7 c4qsgA_ 8 c2xc1A_ 9 c1h2iG_ 10 d2ea9a1 11 d2h28a1 12 c5xf9F_ 13 d1kn0a_ 14 d2inwa1 15 c3j6vE_ 16 c5izrC_ 17 c4g6tB_ 18 c4k15A_ 19 c2z5dA_ 20 c6c23C_ 21 22 23 24 25 26 27 28 29 30 31 32