1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	A	V	I	L	L	P	Q	V	E	R	W	F	F	A	L	N	R	D	A	M	A	S	V	T	G	A	I	D	L	L	E	M	E	G	P	T	L	G	R	P	V	V	D	K	V	N	D	S	T	F	H	N	M	K	E	L	R	P	A
Secondary structure
SS confidence
Disorder		?	?																																?															?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.
Sequence		G	T	S	I	R	I	L	F	A	F	D	P	A	R	Q	A	I	L	L	L	G	G	D	K	A	G	N	W	K	R	W	Y	D	N	N	I	P	I	A	D	Q	R	S	E	N	W	L	A	S	E	H	G	G	G
Secondary structure
SS confidence
Disorder																									?			?	?	?	?	?																			?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 39%) Beta strand ( 29%)

Rank Aligned region

PDB 1wmi chain A domain 1 Region: 2 - 87 Aligned: 84 Modelled: 86 Confidence: 98.7% Identity: 18% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 2khe chain A Region: 2 - 80 Aligned: 76 Modelled: 79 Confidence: 98.5% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:toxin-like protein; PDBTitle: solution structure of the bacterial toxin rele from thermus2 thermophilus hb8 Phyre2 PDB 3bpq chain D Region: 3 - 81 Aligned: 75 Modelled: 79 Confidence: 98.5% Identity: 9% PDB header:toxin Chain: D: PDB Molecule:toxin rele3; PDBTitle: crystal structure of relb-rele antitoxin-toxin complex from2 methanococcus jannaschii Phyre2 PDB 3kix chain Y Region: 2 - 95 Aligned: 87 Modelled: 87 Confidence: 98.2% Identity: 10% PDB header:ribosome Chain: Y: PDB Molecule: PDBTitle: structure of rele nuclease bound to the 70s ribosome (postcleavage2 state; part 3 of 4) Phyre2 PDB 3g5o chain C Region: 2 - 87 Aligned: 80 Modelled: 84 Confidence: 98.0% Identity: 19% PDB header:toxin/antitoxin Chain: C: PDB Molecule:uncharacterized protein rv2866; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis Phyre2 PDB 2a6s chain A domain 1 Region: 1 - 82 Aligned: 79 Modelled: 82 Confidence: 97.7% Identity: 10% Fold: RelE-like Superfamily: RelE-like Family: YoeB/Txe-like Phyre2 PDB 3oei chain H Region: 2 - 82 Aligned: 78 Modelled: 81 Confidence: 97.5% Identity: 15% PDB header:toxin, protein binding Chain: H: PDB Molecule:relk (toxin rv3358); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) Phyre2 PDB 5ja9 chain D Region: 4 - 109 Aligned: 95 Modelled: 106 Confidence: 96.8% Identity: 21% PDB header:toxin Chain: D: PDB Molecule:toxin higb-2; PDBTitle: crystal structure of the higb2 toxin in complex with nb6 Phyre2 PDB 2otr chain A Region: 1 - 80 Aligned: 78 Modelled: 80 Confidence: 95.6% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hp0892; PDBTitle: solution structure of conserved hypothetical protein hp0892 from2 helicobacter pylori Phyre2 PDB 1z8m chain A domain 1 Region: 1 - 81 Aligned: 79 Modelled: 81 Confidence: 90.8% Identity: 20% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 5cw7 chain H Region: 1 - 78 Aligned: 70 Modelled: 78 Confidence: 84.6% Identity: 16% PDB header:toxin Chain: H: PDB Molecule:plasmid stabilization protein pare; PDBTitle: crystal structure of the paaa2-pare2 antitoxin-toxin complex Phyre2 PDB 4q2u chain H Region: 2 - 81 Aligned: 79 Modelled: 80 Confidence: 83.3% Identity: 8% PDB header:toxin/toxin repressor Chain: H: PDB Molecule:mrna interferase yafq; PDBTitle: crystal structure of the e. coli dinj-yafq toxin-antitoxin complex Phyre2 PDB 4mct chain D Region: 15 - 78 Aligned: 62 Modelled: 64 Confidence: 77.8% Identity: 10% PDB header:toxin Chain: D: PDB Molecule:killer protein; PDBTitle: p. vulgaris higba structure, crystal form 1 Phyre2 PDB 5ceg chain B Region: 2 - 80 Aligned: 71 Modelled: 76 Confidence: 47.9% Identity: 11% PDB header:toxin Chain: B: PDB Molecule:plasmid stabilization system; PDBTitle: x-ray structure of toxin/anti-toxin complex from mesorhizobium2 opportunistum Phyre2 PDB 6f8s chain D Region: 20 - 78 Aligned: 55 Modelled: 59 Confidence: 18.1% Identity: 11% PDB header:toxin Chain: D: PDB Molecule:putative killer protein; PDBTitle: toxin-antitoxin complex grata Phyre2 PDB 2kl4 chain A Region: 7 - 38 Aligned: 32 Modelled: 32 Confidence: 17.3% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:bh2032 protein; PDBTitle: nmr structure of the protein nb7804a Phyre2 PDB 2ogf chain D Region: 1 - 43 Aligned: 43 Modelled: 43 Confidence: 15.3% Identity: 26% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein mj0408; PDBTitle: crystal structure of protein mj0408 from methanococcus jannaschii,2 pfam duf372 Phyre2 PDB 2oc6 chain A domain 1 Region: 6 - 84 Aligned: 59 Modelled: 78 Confidence: 12.4% Identity: 10% Fold: Secretion chaperone-like Superfamily: YdhG-like Family: YdhG-like Phyre2 PDB 1kfi chain A domain 4 Region: 42 - 81 Aligned: 31 Modelled: 40 Confidence: 8.6% Identity: 32% Fold: TBP-like Superfamily: Phosphoglucomutase, C-terminal domain Family: Phosphoglucomutase, C-terminal domain Phyre2 PDB 3kxe chain B Region: 18 - 78 Aligned: 52 Modelled: 61 Confidence: 7.9% Identity: 15% PDB header:protein binding Chain: B: PDB Molecule:toxin protein pare-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex Phyre2 1 d1wmia1 2 c2kheA_ 3 c3bpqD_ 4 c3kixy_ 5 c3g5oC_ 6 d2a6sa1 7 c3oeiH_ 8 c5ja9D_ 9 c2otrA_ 10 d1z8ma1 11 c5cw7H_ 12 c4q2uH_ 13 c4mctD_ 14 c5cegB_ 15 c6f8sD_ 16 c2kl4A_ 17 c2ogfD_ 18 d2oc6a1 19 d1kfia4 20 c3kxeB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35