1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	A	H	V	A	T	L	H	P	E	P	P	F	A	L	C	G	P	R	G	T	L	I	A	R	G	V	R	T	R	Y	C	D	V	R	A	A	Q	A	A	L	R	S	G	T	A	P	I	L	L	G	A	L	P	F	D	V	S	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	A	A	L	M	V	P	D	G	V	L	R	A	R	K	L	P	D	W	P	T	G	P	L	P	K	V	R	V	A	A	A	L	P	P	P	A	D	Y	L	T	R	I	G	R	A	R	D	L	L	A	A	F	D	G	P	L	H	K	V
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	L	A	R	A	V	Q	L	T	A	D	A	P	L	D	A	R	V	L	L	R	R	L	V	V	A	D	P	T	A	Y	G	Y	L	V	D	L	T	S	A	G	N	D	D	T	G	A	A	L	V	G	A	S	P	E	L	L	V	A	R
Secondary structure
SS confidence
Disorder																																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	G	N	R	V	M	C	K	P	F	A	G	S	A	P	R	A	A	D	P	K	L	D	A	A	N	A	A	A	L	A	S	S	A	K	N	R	H	E	H	Q	L	V	V	D	T	M	R	V	A	L	E	P	L	C	E	D	L	T	I
Secondary structure
SS confidence
Disorder																			?													?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	A	Q	P	Q	L	N	R	T	A	A	V	W	H	L	C	T	A	I	T	G	R	L	R	N	I	S	T	T	A	I	D	L	A	L	A	L	H	P	T	P	A	V	G	G	V	P	T	K	A	A	T	E	L	I	A	E	L	E	G
Secondary structure
SS confidence
Disorder			?		?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	R	G	F	Y	A	G	A	V	G	W	C	D	G	R	G	D	G	H	W	V	V	S	I	R	C	A	Q	L	S	A	D	R	R	A	A	L	A	H	A	G	G	G	I	V	A	E	S	D	P	D	D	E	L	E	E	T	T	T	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.
Sequence		F	A	T	I	L	T	A	L	G	V	E	Q
Secondary structure
SS confidence
Disorder									?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 31%) Beta strand ( 29%)

Rank Aligned region

PDB 3os6 chain A Region: 1 - 371 Aligned: 359 Modelled: 371 Confidence: 100.0% Identity: 39% PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. Phyre2 PDB 3hwo chain B Region: 6 - 371 Aligned: 354 Modelled: 365 Confidence: 100.0% Identity: 41% PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate Phyre2 PDB 3bzn chain A domain 1 Region: 5 - 368 Aligned: 349 Modelled: 363 Confidence: 100.0% Identity: 30% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1qdl chain A Region: 10 - 371 Aligned: 348 Modelled: 362 Confidence: 100.0% Identity: 28% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2fn0 chain A domain 1 Region: 1 - 370 Aligned: 355 Modelled: 370 Confidence: 100.0% Identity: 25% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3gse chain A Region: 5 - 364 Aligned: 343 Modelled: 360 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 Phyre2 PDB 4pen chain A Region: 74 - 372 Aligned: 291 Modelled: 299 Confidence: 100.0% Identity: 29% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component 1; PDBTitle: structure of anthranilate synthase component i (trpe) from2 mycobacterium tuberculosis with inhibitor bound Phyre2 PDB 2g5f chain A domain 1 Region: 80 - 371 Aligned: 278 Modelled: 292 Confidence: 100.0% Identity: 29% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i1q chain A Region: 75 - 368 Aligned: 279 Modelled: 294 Confidence: 100.0% Identity: 27% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i7q chain A Region: 74 - 368 Aligned: 280 Modelled: 295 Confidence: 100.0% Identity: 26% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3r74 chain B Region: 9 - 372 Aligned: 351 Modelled: 351 Confidence: 100.0% Identity: 22% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 3h9m chain A Region: 35 - 368 Aligned: 303 Modelled: 308 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase, component i from2 cytophaga hutchinsonii Phyre2 PDB 2i6y chain A Region: 11 - 368 Aligned: 332 Modelled: 351 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti Phyre2 PDB 4grh chain A Region: 68 - 369 Aligned: 276 Modelled: 288 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:aminodeoxychorismate synthase; PDBTitle: crystal structure of pabb of stenotrophomonas maltophilia Phyre2 PDB 5kck chain A Region: 73 - 366 Aligned: 271 Modelled: 294 Confidence: 100.0% Identity: 31% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i; PDBTitle: crystal structure of anthranilate synthase component i from2 streptococcus pneumoniae tigr4 Phyre2 PDB 1k0g chain A Region: 13 - 368 Aligned: 311 Modelled: 332 Confidence: 100.0% Identity: 25% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3nqk chain A Region: 303 - 341 Aligned: 38 Modelled: 39 Confidence: 37.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution Phyre2 PDB 2ffc chain A domain 1 Region: 281 - 368 Aligned: 83 Modelled: 88 Confidence: 29.2% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Decarboxylase Phyre2 PDB 1hxr chain A Region: 307 - 324 Aligned: 18 Modelled: 18 Confidence: 28.0% Identity: 22% Fold: Mss4-like Superfamily: Mss4-like Family: RabGEF Mss4 Phyre2 PDB 2fu5 chain A domain 1 Region: 307 - 324 Aligned: 18 Modelled: 18 Confidence: 27.8% Identity: 22% Fold: Mss4-like Superfamily: Mss4-like Family: RabGEF Mss4 Phyre2 1 c3os6A_ 2 c3hwoB_ 3 d3bzna1 4 d1qdla_ 5 d2fn0a1 6 c3gseA_ 7 c4penA_ 8 d2g5fa1 9 d1i1qa_ 10 d1i7qa_ 11 c3r74B_ 12 c3h9mA_ 13 c2i6yA_ 14 c4grhA_ 15 c5kckA_ 16 d1k0ga_ 17 c3nqkA_ 18 d2ffca1 19 d1hxra_ 20 d2fu5a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71