1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	E	N	C	G	P	T	D	A	H	A	D	H	D	D	S	H	G	G	M	G	C	A	E	V	I	A	E	V	W	T	L	L	D	G	E	C	T	P	E	T	R	E	R	L	R	R	H	L	E	A	C	P	G	C	L	R	H	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.
Sequence		G	L	E	E	R	I	K	A	L	I	G	T	K	C	R	G	D	R	A	P	E	G	L	R	E	R	L	R	L	E	I	R	R	T	T	I	I	R	G	G	P
Secondary structure
SS confidence
Disorder																		?	?	?												?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 35%) Alpha helix ( 64%) Beta strand ( 0%)

Rank Aligned region

PDB 5frh chain A Region: 12 - 101 Aligned: 90 Modelled: 90 Confidence: 99.7% Identity: 22% PDB header:transcription Chain: A: PDB Molecule:anti-sigma factor rsra; PDBTitle: solution structure of oxidised rsra Phyre2 PDB 5wuq chain D Region: 23 - 91 Aligned: 68 Modelled: 69 Confidence: 99.4% Identity: 26% PDB header:metal binding protein Chain: D: PDB Molecule:anti-sigma-w factor rsiw; PDBTitle: crystal structure of sigw in complex with its anti-sigma rsiw, a zinc2 binding form Phyre2 PDB 3vdo chain B Region: 25 - 92 Aligned: 67 Modelled: 68 Confidence: 99.3% Identity: 13% PDB header:dna binding protein/protein binding Chain: B: PDB Molecule:anti-sigma-k factor rska; PDBTitle: structure of extra-cytoplasmic function(ecf) sigma factor sigk in2 complex with its negative regulator rska from mycobacterium3 tuberculosis Phyre2 PDB 2z2s chain D Region: 28 - 91 Aligned: 64 Modelled: 61 Confidence: 98.9% Identity: 14% PDB header:transcription Chain: D: PDB Molecule:anti-sigma factor chrr, transcriptional activator chrr; PDBTitle: crystal structure of rhodobacter sphaeroides sige in complex with the2 anti-sigma chrr Phyre2 PDB 3hug chain J Region: 28 - 82 Aligned: 55 Modelled: 55 Confidence: 98.9% Identity: 20% PDB header:transcription/membrane protein Chain: J: PDB Molecule:probable conserved membrane protein; PDBTitle: crystal structure of mycobacterium tuberculosis anti-sigma factor rsla2 in complex with -35 promoter binding domain of sigl Phyre2 PDB 6in7 chain A Region: 21 - 92 Aligned: 70 Modelled: 72 Confidence: 98.9% Identity: 6% PDB header:transcription Chain: A: PDB Molecule:sigma factor algu negative regulatory protein; PDBTitle: crystal structure of algu in complex with muca(cyto) Phyre2 PDB 1or7 chain C Region: 28 - 92 Aligned: 61 Modelled: 65 Confidence: 97.2% Identity: 18% Fold: N-terminal, cytoplasmic domain of anti-sigmaE factor RseA Superfamily: N-terminal, cytoplasmic domain of anti-sigmaE factor RseA Family: N-terminal, cytoplasmic domain of anti-sigmaE factor RseA Phyre2 PDB 1or7 chain C Region: 28 - 92 Aligned: 61 Modelled: 65 Confidence: 97.2% Identity: 18% PDB header:transcription Chain: C: PDB Molecule:sigma-e factor negative regulatory protein; PDBTitle: crystal structure of escherichia coli sigmae with the cytoplasmic2 domain of its anti-sigma rsea Phyre2 PDB 5cam chain C Region: 23 - 72 Aligned: 50 Modelled: 50 Confidence: 40.6% Identity: 8% PDB header:transcription Chain: C: PDB Molecule:pupr protein; PDBTitle: crystal structure of the cytoplasmic domain of the pseudomonas putida2 anti-sigma factor pupr (semet) Phyre2 PDB 2xuv chain B Region: 15 - 29 Aligned: 15 Modelled: 15 Confidence: 40.1% Identity: 27% PDB header:unknown function Chain: B: PDB Molecule:hdeb; PDBTitle: the structure of hdeb Phyre2 PDB 2db7 chain A domain 1 Region: 24 - 53 Aligned: 30 Modelled: 30 Confidence: 39.3% Identity: 27% Fold: Orange domain-like Superfamily: Orange domain-like Family: Hairy Orange domain Phyre2 PDB 5fmn chain B Region: 22 - 53 Aligned: 31 Modelled: 32 Confidence: 33.1% Identity: 29% PDB header:dna binding protein Chain: B: PDB Molecule:inrs; PDBTitle: the nickel-responsive transcriptional regulator inrs Phyre2 PDB 5ze4 chain A Region: 22 - 56 Aligned: 33 Modelled: 35 Confidence: 28.9% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:dihydroxy-acid dehydratase, chloroplastic; PDBTitle: the structure of holo- structure of dhad complex with [2fe-2s] cluster Phyre2 PDB 2hh7 chain A Region: 22 - 53 Aligned: 31 Modelled: 32 Confidence: 27.7% Identity: 26% PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein csor; PDBTitle: crystal structure of cu(i) bound csor from mycobacterium tuberculosis. Phyre2 PDB 5lcy chain D Region: 22 - 53 Aligned: 31 Modelled: 32 Confidence: 27.3% Identity: 16% PDB header:transcription Chain: D: PDB Molecule:frmr; PDBTitle: formaldehyde-responsive regulator frmr e64h variant from salmonella2 enterica serovar typhimurium Phyre2 PDB 3aai chain B Region: 23 - 53 Aligned: 30 Modelled: 31 Confidence: 26.2% Identity: 23% PDB header:transcription Chain: B: PDB Molecule:copper homeostasis operon regulatory protein; PDBTitle: x-ray crystal structure of csor from thermus thermophilus hb8 Phyre2 PDB 5lbm chain D Region: 22 - 53 Aligned: 31 Modelled: 32 Confidence: 24.5% Identity: 16% PDB header:transcription Chain: D: PDB Molecule:transcriptional repressor frmr; PDBTitle: the asymmetric tetrameric structure of the formaldehyde sensing2 transcriptional repressor frmr from escherichia coli Phyre2 PDB 4m1p chain A Region: 22 - 53 Aligned: 31 Modelled: 32 Confidence: 23.7% Identity: 16% PDB header:transcription repressor Chain: A: PDB Molecule:copper-sensitive operon repressor (csor); PDBTitle: crystal structure of the copper-sensing repressor csor with cu(i) from2 geobacillus thermodenitrificans ng80-2 Phyre2 PDB 4adz chain A Region: 22 - 53 Aligned: 31 Modelled: 32 Confidence: 23.1% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:csor; PDBTitle: crystal structure of the apo form of a copper-sensitive operon2 regulator (csor) protein from streptomyces lividans Phyre2 PDB 5oyn chain B Region: 12 - 56 Aligned: 43 Modelled: 45 Confidence: 22.9% Identity: 14% PDB header:lyase Chain: B: PDB Molecule:dehydratase, ilvd/edd family; PDBTitle: crystal structure of d-xylonate dehydratase in holo-form Phyre2 1 c5frhA_ 2 c5wuqD_ 3 c3vdoB_ 4 c2z2sD_ 5 c3hugJ_ 6 c6in7A_ 7 d1or7c_ 8 c1or7C_ 9 c5camC_ 10 c2xuvB_ 11 d2db7a1 12 c5fmnB_ 13 c5ze4A_ 14 c2hh7A_ 15 c5lcyD_ 16 c3aaiB_ 17 c5lbmD_ 18 c4m1pA_ 19 c4adzA_ 20 c5oynB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83