1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	K	T	W	P	A	P	T	A	P	T	P	V	R	A	T	V	T	V	P	G	S	K	S	Q	T	N	R	A	L	V	L	A	A	L	A	A	A	Q	G	R	G	A	S	T	I	S	G	A	L	R	S	R	D	T	E	L	M	L	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?			?						?	?	?		?													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	L	Q	T	L	G	L	R	V	D	G	V	G	S	E	L	T	V	S	G	R	I	E	P	G	P	G	A	R	V	D	C	G	L	A	G	T	V	L	R	F	V	P	P	L	A	A	L	G	S	V	P	V	T	F	D	G	D	Q	Q
Secondary structure
SS confidence
Disorder																							?	?	?	?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	R	G	R	P	I	A	P	L	L	D	A	L	R	E	L	G	V	A	V	D	G	T	G	L	P	F	R	V	R	G	N	G	S	L	A	G	G	T	V	A	I	D	A	S	A	S	S	Q	F	V	S	G	L	L	L	S	A	A	S
Secondary structure
SS confidence
Disorder		?			?																																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	T	D	G	L	T	V	Q	H	T	G	S	S	L	P	S	A	P	H	I	A	M	T	A	A	M	L	R	Q	A	G	V	D	I	D	D	S	T	P	N	R	W	Q	V	R	P	G	P	V	A	A	R	R	W	D	I	E	P	D	L
Secondary structure
SS confidence
Disorder																																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	N	A	V	A	F	L	S	A	A	V	V	S	G	G	T	V	R	I	T	G	W	P	R	V	S	V	Q	P	A	D	H	I	L	A	I	L	R	Q	L	N	A	V	V	I	H	A	D	S	S	L	E	V	R	G	P	T	G	Y	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	F	D	V	D	L	R	A	V	G	E	L	T	P	S	V	A	A	L	A	A	L	A	S	P	G	S	V	S	R	L	S	G	I	A	H	L	R	G	H	E	T	D	R	L	A	A	L	S	T	E	I	N	R	L	G	G	T	C	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	T	P	D	G	L	V	I	T	A	T	P	L	R	P	G	I	W	R	A	Y	A	D	H	R	M	A	M	A	G	A	I	I	G	L	R	V	A	G	V	E	V	D	D	I	A	A	T	T	K	T	L	P	E	F	P	R	L	W	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450
Sequence		E	M	V	G	P	G	Q	G	W	G	Y	P	Q	P	R	S	G	Q	R	A	R	R	A	T	G	Q	G	S	G	G
Secondary structure
SS confidence
Disorder						?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 35%) Beta strand ( 23%) TM helix ( 18%) (View membrane topology prediction)

Rank Aligned region

PDB 2o0z chain A Region: 1 - 424 Aligned: 424 Modelled: 424 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:3-phosphoshikimate 1-carboxyvinyltransferase; PDBTitle: mycobacterium tuberculosis epsp synthase in complex with product (eps) Phyre2 PDB 1g6s chain A Region: 1 - 423 Aligned: 409 Modelled: 423 Confidence: 100.0% Identity: 32% Fold: IF3-like Superfamily: EPT/RTPC-like Family: Enolpyruvate transferase, EPT Phyre2 PDB 5xwb chain B Region: 1 - 422 Aligned: 409 Modelled: 422 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: B: PDB Molecule:3-phosphoshikimate 1-carboxyvinyltransferase; PDBTitle: crystal structure of 5-enolpyruvulshikimate-3-phosphate synthase from2 a psychrophilic bacterium, colwellia psychrerythraea Phyre2 PDB 5buf chain A Region: 1 - 425 Aligned: 407 Modelled: 421 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:3-phosphoshikimate 1-carboxyvinyltransferase; PDBTitle: 2.37 angstrom structure of epsp synthase from acinetobacter baumannii Phyre2 PDB 1rf6 chain A Region: 8 - 424 Aligned: 402 Modelled: 401 Confidence: 100.0% Identity: 24% Fold: IF3-like Superfamily: EPT/RTPC-like Family: Enolpyruvate transferase, EPT Phyre2 PDB 3roi chain A Region: 1 - 433 Aligned: 409 Modelled: 428 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:3-phosphoshikimate 1-carboxyvinyltransferase; PDBTitle: 2.20 angstrom resolution structure of 3-phosphoshikimate 1-2 carboxyvinyltransferase (aroa) from coxiella burnetii Phyre2 PDB 3r38 chain A Region: 1 - 436 Aligned: 409 Modelled: 434 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase 1; PDBTitle: 2.23 angstrom resolution crystal structure of udp-n-acetylglucosamine2 1-carboxyvinyltransferase (mura) from listeria monocytogenes egd-e Phyre2 PDB 2pqd chain A Region: 9 - 425 Aligned: 402 Modelled: 417 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:3-phosphoshikimate 1-carboxyvinyltransferase; PDBTitle: a100g cp4 epsps liganded with (r)-difluoromethyl tetrahedral reaction2 intermediate analog Phyre2 PDB 5ujs chain B Region: 1 - 425 Aligned: 399 Modelled: 417 Confidence: 100.0% Identity: 19% PDB header:hydrolase,oxidoreductase Chain: B: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase; PDBTitle: 2.45 angstrom resolution crystal structure of udp-n-acetylglucosamine2 1-carboxyvinyltransferase from campylobacter jejuni. Phyre2 PDB 3rmt chain B Region: 10 - 425 Aligned: 395 Modelled: 413 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:3-phosphoshikimate 1-carboxyvinyltransferase 1; PDBTitle: crystal structure of putative 5-enolpyruvoylshikimate-3-phosphate2 synthase from bacillus halodurans c-125 Phyre2 PDB 1ejd chain A Region: 10 - 425 Aligned: 396 Modelled: 412 Confidence: 100.0% Identity: 19% Fold: IF3-like Superfamily: EPT/RTPC-like Family: Enolpyruvate transferase, EPT Phyre2 PDB 5u4h chain B Region: 1 - 428 Aligned: 404 Modelled: 423 Confidence: 100.0% Identity: 18% PDB header:lipid-binding protein Chain: B: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase; PDBTitle: 1.05 angstrom resolution crystal structure of udp-n-acetylglucosamine2 1-carboxyvinyltransferase from acinetobacter baumannii in covalently3 bound complex with (2r)-2-(phosphonooxy)propanoic acid. Phyre2 PDB 1uae chain A Region: 10 - 425 Aligned: 396 Modelled: 412 Confidence: 100.0% Identity: 18% Fold: IF3-like Superfamily: EPT/RTPC-like Family: Enolpyruvate transferase, EPT Phyre2 PDB 5wi5 chain C Region: 1 - 425 Aligned: 403 Modelled: 418 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: C: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase 1; PDBTitle: 2.0 angstrom resolution crystal structure of udp-n-acetylglucosamine2 1-carboxyvinyltransferase from streptococcus pneumoniae in complex3 with uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2r)-4 2-(phosphonooxy)propanoic acid and magnesium. Phyre2 PDB 5bq2 chain C Region: 1 - 425 Aligned: 400 Modelled: 420 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: C: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase; PDBTitle: crystal structure of udp-n-acetylglucosamine 1-carboxyvinyltransferase2 (udp-n-acetylglucosamine enolpyruvyl transferase, ept) from3 pseudomonas aeruginosa Phyre2 PDB 3zh3 chain A Region: 1 - 425 Aligned: 395 Modelled: 419 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase; PDBTitle: crystal structure of s. pneumoniae d39 native mura1 Phyre2 PDB 4fqd chain A Region: 1 - 432 Aligned: 404 Modelled: 421 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:niko protein; PDBTitle: crystal structure of the enolpyruvyl transferase niko from2 streptomyces tendae Phyre2 PDB 2yvw chain A Region: 1 - 425 Aligned: 399 Modelled: 415 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine 1-carboxyvinyltransferase; PDBTitle: crystal structure of udp-n-acetylglucosamine 1-carboxyvinyltransferase2 from aquifex aeolicus vf5 Phyre2 PDB 1p88 chain A Region: 26 - 237 Aligned: 207 Modelled: 212 Confidence: 100.0% Identity: 31% Fold: IF3-like Superfamily: EPT/RTPC-like Family: Enolpyruvate transferase, EPT Phyre2 PDB 1qmh chain A domain 2 Region: 96 - 294 Aligned: 197 Modelled: 198 Confidence: 96.1% Identity: 19% Fold: IF3-like Superfamily: EPT/RTPC-like Family: RNA 3'-terminal phosphate cyclase, RPTC Phyre2 1 c2o0zA_ 2 d1g6sa_ 3 c5xwbB_ 4 c5bufA_ 5 d1rf6a_ 6 c3roiA_ 7 c3r38A_ 8 c2pqdA_ 9 c5ujsB_ 10 c3rmtB_ 11 d1ejda_ 12 c5u4hB_ 13 d1uaea_ 14 c5wi5C_ 15 c5bq2C_ 16 c3zh3A_ 17 c4fqdA_ 18 c2yvwA_ 19 d1p88a_ 20 d1qmha2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99