1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	Q	V	Y	I	P	A	T	L	A	M	L	Q	R	L	V	A	D	G	A	L	W	P	V	N	G	T	A	F	A	V	T	P	T	L	R	E	S	Y	A	E	G	D	D	E	E	L	A	E	V	A	L	R	E	A	A	L	A	S
Secondary structure
SS confidence
Disorder		?	?				?	?											?	?	?	?	?	?	?	?	?																?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	R	L	L	A	A	D	I	G	A	T	A	D	A	L	P	P	R	R	A	V	L	A	A	E	V	D	D	A	T	Y	R	P	D	L	D	D	A	V	V	R	L	A	G	P	I	T	I	D	Q	V	V	A	A	Y	V	D	N	A	G
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.
Sequence		A	E	P	A	V	M	A	A	I	A	V	I	D	A	A	D	L	G	D	E	D	A	E	L	V	V	G	D	A	Q	D	H	D	L	A	W	Y	A	N	Q	E	L	P	F	L	L	D	L	L
Secondary structure
SS confidence
Disorder														?	?	?	?	?			?																												?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 44%) Beta strand ( 17%)

Rank Aligned region

PDB 1nbj chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 29.8% Identity: 60% PDB header:plant protein Chain: A: PDB Molecule:cycloviolacin o1; PDBTitle: high-resolution solution structure of cycloviolacin o1 Phyre2 PDB 1nbj chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 29.8% Identity: 60% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Cyclotides Family: Cycloviolacin Phyre2 PDB 1df6 chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 18.5% Identity: 60% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Cyclotides Family: Cycloviolacin Phyre2 PDB 1df6 chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 18.5% Identity: 60% PDB header:plant protein Chain: A: PDB Molecule:cycloviolacin o1; PDBTitle: 1h nmr solution structure of cycloviolacin o1 Phyre2 PDB 1d0g chain R domain 3 Region: 92 - 115 Aligned: 24 Modelled: 24 Confidence: 18.0% Identity: 8% Fold: TNF receptor-like Superfamily: TNF receptor-like Family: TNF receptor-like Phyre2 PDB 6amb chain B Region: 1 - 9 Aligned: 9 Modelled: 9 Confidence: 15.0% Identity: 44% PDB header:signaling protein Chain: B: PDB Molecule:afadin; PDBTitle: crystal structure of the afadin ra1 domain in complex with hras Phyre2 PDB 3dwm chain A Region: 2 - 42 Aligned: 39 Modelled: 41 Confidence: 9.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:9.5 kda culture filtrate antigen cfp10a; PDBTitle: crystal structure of mycobacterium tuberculosis cyso, an antigen Phyre2 PDB 5ujd chain B Region: 1 - 34 Aligned: 33 Modelled: 34 Confidence: 8.5% Identity: 21% PDB header:gene regulation Chain: B: PDB Molecule:siderophore biosynthesis protein sbni; PDBTitle: sbni from staphylococcus pseudintermedius Phyre2 PDB 6jdp chain A Region: 34 - 53 Aligned: 20 Modelled: 20 Confidence: 8.5% Identity: 30% PDB header:antitoxin Chain: A: PDB Molecule:imm52 family protein; PDBTitle: the imm52 family protein tsit (pa3908) from pseudomonas aeruginosa Phyre2 PDB 4n6e chain B Region: 2 - 42 Aligned: 39 Modelled: 41 Confidence: 8.3% Identity: 15% PDB header:lyase/biosynthetic protein Chain: B: PDB Molecule:this/moad family protein; PDBTitle: crystal structure of amycolatopsis orientalis bexx/cyso complex Phyre2 PDB 1vb8 chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 7.0% Identity: 50% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Cyclotides Family: Cycloviolacin Phyre2 PDB 1vb8 chain A Region: 4 - 13 Aligned: 10 Modelled: 10 Confidence: 7.0% Identity: 50% PDB header:plant protein Chain: A: PDB Molecule:viola hederacea root peptide 1; PDBTitle: solution structure of vhr1, the first cyclotide from root2 tissue Phyre2 PDB 2q6m chain A Region: 1 - 7 Aligned: 7 Modelled: 7 Confidence: 6.8% Identity: 57% PDB header:toxin Chain: A: PDB Molecule:cholix toxin; PDBTitle: catalytic fragment of cholix toxin from vibrio cholerae in complex2 with the pj34 inhibitor Phyre2 1 c1nbjA_ 2 d1nbja_ 3 d1df6a_ 4 c1df6A_ 5 d1d0gr3 6 c6ambB_ 7 c3dwmA_ 8 c5ujdB_ 9 c6jdpA_ 10 c4n6eB_ 11 d1vb8a_ 12 c1vb8A_ 13 c2q6mA_