1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	A	G	A	L	G	N	W	L	M	S	R	G	E	A	V	A	P	T	A	T	V	R	A	M	A	P	L	S	V	Y	A	D	D	Q	L	D	S	T	G	P	G	Q	A	I	S	Q	V	T	P	F	L	V	D	L	P	V	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?										?	?	?	?		?														?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	N	A	V	V	R	L	S	Q	I	A	H	A	T	E	S	N	P	T	A	A	S	L	V	D	A	R	T	I	V	T	L	S	G	L	A	P	A	T	L	H	A	M	G	V	R	V	A	T	S	F	S	A	R	L	F	N	L	L	I
Secondary structure
SS confidence
Disorder																				?	?	?	?		?	?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	N	A	P	G	T	Q	S	Q	M	Y	I	A	G	T	K	L	L	E	T	Y	S	V	P	P	L	L	H	N	Q	A	L	A	I	S	V	T	S	Y	N	G	M	L	Y	F	G	I	N	A	D	R	D	A	M	S	D	V	D	L	L
Secondary structure
SS confidence
Disorder																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.
Sequence		P	G	L	L	S	Q	A	L	D	E	L	L	E	A	S	R
Secondary structure
SS confidence
Disorder																?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 38%) Beta strand ( 29%) TM helix ( 21%) (View membrane topology prediction)

Rank Aligned region

PDB 6chj chain B Region: 2 - 195 Aligned: 171 Modelled: 174 Confidence: 99.9% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:diacylglycerol o-acyltransferase; PDBTitle: wax ester synthase/diacylglycerol acyltransferase from marinobacter2 aquaeolei vt8 Phyre2 PDB 1q9j chain A domain 2 Region: 1 - 193 Aligned: 174 Modelled: 193 Confidence: 98.5% Identity: 13% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: NRPS condensation domain (amide synthase) Phyre2 PDB 1q9j chain A Region: 1 - 193 Aligned: 174 Modelled: 193 Confidence: 98.4% Identity: 13% PDB header:ligase Chain: A: PDB Molecule:polyketide synthase associated protein 5; PDBTitle: structure of polyketide synthase associated protein 5 from2 mycobacterium tuberculosis Phyre2 PDB 5m6p chain B Region: 1 - 193 Aligned: 178 Modelled: 182 Confidence: 97.8% Identity: 13% PDB header:isomerase Chain: B: PDB Molecule:tyrocidine synthase 2; PDBTitle: crystal structure of the epimerization domain from module 3 of2 tyrocidine synthetase b, tycb3(e) Phyre2 PDB 2jgp chain A Region: 1 - 193 Aligned: 174 Modelled: 193 Confidence: 97.6% Identity: 11% PDB header:ligase Chain: A: PDB Molecule:tyrocidine synthetase 3; PDBTitle: structure of the tycc5-6 pcp-c bidomain of the tyrocidine synthetase2 tycc Phyre2 PDB 5dij chain A Region: 1 - 193 Aligned: 176 Modelled: 193 Confidence: 97.4% Identity: 9% PDB header:unknown function Chain: A: PDB Molecule:tqaa; PDBTitle: the crystal structure of ct Phyre2 PDB 5t81 chain A Region: 1 - 193 Aligned: 175 Modelled: 193 Confidence: 97.3% Identity: 14% PDB header:biosynthetic protein Chain: A: PDB Molecule:epob; PDBTitle: rhombohedral crystal form of the epob nrps cyclization-docking2 bidomain from sorangium cellulosum Phyre2 PDB 2xhg chain A Region: 1 - 193 Aligned: 178 Modelled: 193 Confidence: 97.1% Identity: 12% PDB header:isomerase Chain: A: PDB Molecule:tyrocidine synthetase a; PDBTitle: crystal structure of the epimerization domain from the initiation2 module of tyrocidine biosynthesis Phyre2 PDB 6ad3 chain A Region: 1 - 193 Aligned: 179 Modelled: 193 Confidence: 97.1% Identity: 9% PDB header:biosynthetic protein Chain: A: PDB Molecule:lovastatin nonaketide synthase moka; PDBTitle: structural characterization of the condensation domain from monacolin2 k polyketide synthase moka Phyre2 PDB 6aef chain B Region: 1 - 193 Aligned: 173 Modelled: 193 Confidence: 97.1% Identity: 9% PDB header:transferase Chain: B: PDB Molecule:polyketide synthase associated protein papa2; PDBTitle: papa2 acyl transferase Phyre2 PDB 5t3e chain A Region: 1 - 194 Aligned: 175 Modelled: 194 Confidence: 97.0% Identity: 10% PDB header:ligase Chain: A: PDB Molecule:bacillamide synthetase heterocyclization domain; PDBTitle: crystal structure of a nonribosomal peptide synthetase2 heterocyclization domain. Phyre2 PDB 2e1u chain A Region: 1 - 188 Aligned: 167 Modelled: 188 Confidence: 94.7% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:acyl transferase; PDBTitle: crystal structure of dendranthema morifolium dmat Phyre2 PDB 5u89 chain A Region: 1 - 193 Aligned: 165 Modelled: 170 Confidence: 94.5% Identity: 16% PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:amino acid adenylation domain protein; PDBTitle: crystal structure of a cross-module fragment from the dimodular nrps2 dhbf Phyre2 PDB 4tx3 chain B Region: 1 - 193 Aligned: 177 Modelled: 193 Confidence: 93.2% Identity: 14% PDB header:oxidoreductase Chain: B: PDB Molecule:peptide synthetase, module 7; PDBTitle: complex of the x-domain and oxyb from teicoplanin biosynthesis Phyre2 PDB 6m7l chain B Region: 1 - 193 Aligned: 176 Modelled: 193 Confidence: 92.9% Identity: 11% PDB header:biosynthetic protein Chain: B: PDB Molecule:putative non-ribosomal peptide synthetase; PDBTitle: complex of oxya with the x-domain from gpa biosynthesis Phyre2 PDB 6cgo chain B Region: 1 - 194 Aligned: 175 Modelled: 194 Confidence: 92.6% Identity: 11% PDB header:biosynthetic protein Chain: B: PDB Molecule:condensation domain protein; PDBTitle: molecular basis for condensation domain-mediated chain release from2 the enacyloxin polyketide synthase Phyre2 PDB 1ndb chain A domain 2 Region: 67 - 193 Aligned: 111 Modelled: 124 Confidence: 91.9% Identity: 16% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: Choline/Carnitine O-acyltransferase Phyre2 PDB 4znm chain B Region: 1 - 193 Aligned: 172 Modelled: 178 Confidence: 91.6% Identity: 8% PDB header:ligase Chain: B: PDB Molecule:c-domain type ii peptide synthetase; PDBTitle: crystal structure of sgcc5 protein from streptomyces globisporus (apo2 form) Phyre2 PDB 4g0b chain A Region: 1 - 191 Aligned: 176 Modelled: 191 Confidence: 91.5% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:hydroxycinnamoyl-coa shikimate/quinate PDBTitle: structure of native hct from coffea canephora Phyre2 PDB 1l5a chain A Region: 1 - 193 Aligned: 168 Modelled: 191 Confidence: 90.4% Identity: 13% PDB header:biosynthetic protein Chain: A: PDB Molecule:amide synthase; PDBTitle: crystal structure of vibh, an nrps condensation enzyme Phyre2 1 c6chjB_ 2 d1q9ja2 3 c1q9jA_ 4 c5m6pB_ 5 c2jgpA_ 6 c5dijA_ 7 c5t81A_ 8 c2xhgA_ 9 c6ad3A_ 10 c6aefB_ 11 c5t3eA_ 12 c2e1uA_ 13 c5u89A_ 14 c4tx3B_ 15 c6m7lB_ 16 c6cgoB_ 17 d1ndba2 18 c4znmB_ 19 c4g0bA_ 20 c1l5aA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70