1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	E	V	S	R	A	L	L	F	E	L	G	V	L	L	A	V	L	A	V	L	G	A	V	A	R	R	F	A	L	S	P	I	P	V	Y	L	L	A	G	L	S	L	G	N	G	G	I	L	G	V	A	A	A	G	E	F	I	A	T
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	A	P	I	G	V	V	L	L	L	L	A	L	G	L	E	F	S	A	T	E	F	A	S	S	L	R	H	H	L	P	S	A	G	V	D	I	V	L	N	A	T	P	G	A	V	A	G	W	L	L	G	L	D	G	V	A	I	L	G
Secondary structure
SS confidence
Disorder																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	A	G	V	T	Y	I	S	S	S	G	V	I	A	R	L	L	E	D	L	R	R	L	G	N	R	E	T	P	A	V	L	S	V	L	V	L	E	D	F	A	M	A	A	Y	L	P	L	F	A	V	L	A	T	D	G	S	W	L	E
Secondary structure
SS confidence
Disorder																					?	?	?	?	?																													?	?		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	V	G	M	T	V	A	I	A	A	L	L	G	A	F	A	A	S	Y	R	W	G	H	H	V	G	R	L	V	T	H	P	D	S	E	Q	L	L	L	R	V	L	G	I	T	L	I	V	A	A	V	A	E	S	L	H	A	S	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	V	G	A	F	L	V	G	L	T	L	T	G	E	T	A	D	R	A	R	M	V	L	T	P	L	R	D	L	F	A	T	I	F	F	L	G	I	G	L	S	V	D	P	G	K	L	V	S	M	L	P	V	A	L	A	L	A	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	A	A	T	K	V	A	T	G	M	F	A	A	R	R	E	G	V	A	R	R	G	Q	L	R	A	G	T	A	L	V	A	R	G	E	F	S	L	I	I	I	G	L	A	G	A	S	I	P	G	V	A	A	L	A	T	A	Y	V	F
Secondary structure
SS confidence
Disorder																															?	?														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.
Sequence		V	M	A	I	V	G	P	I	L	A	R	Y	T	G	G	G	L	P	A	A	A	V	A	S	N
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 85%) Beta strand ( 0%) TM helix ( 63%) (View membrane topology prediction)

Rank Aligned region

PDB 4bwz chain A Region: 6 - 383 Aligned: 376 Modelled: 378 Confidence: 100.0% Identity: 22% PDB header:transport protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: crystal structure of the sodium proton antiporter, napa Phyre2 PDB 5bz3 chain A Region: 6 - 383 Aligned: 376 Modelled: 378 Confidence: 100.0% Identity: 22% PDB header:transport protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: crystal structure of sodium proton antiporter napa in outward-facing2 conformation. Phyre2 PDB 4czb chain B Region: 5 - 383 Aligned: 378 Modelled: 379 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: structure of the sodium proton antiporter mjnhap1 from2 methanocaldococcus jannaschii at ph 8. Phyre2 PDB 4cz8 chain A Region: 2 - 377 Aligned: 374 Modelled: 375 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:na+/h+ antiporter, putative; PDBTitle: structure of the sodium proton antiporter panhap from2 pyrococcus abyssii at ph 8. Phyre2 PDB 1zcd chain A Region: 12 - 377 Aligned: 346 Modelled: 352 Confidence: 99.9% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: crystal structure of the na+/h+ antiporter nhaa Phyre2 PDB 4n7w chain A Region: 36 - 383 Aligned: 295 Modelled: 300 Confidence: 98.5% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:transporter, sodium/bile acid symporter family; PDBTitle: crystal structure of the sodium bile acid symporter from yersinia2 frederiksenii Phyre2 PDB 2mdf chain A Region: 112 - 165 Aligned: 54 Modelled: 54 Confidence: 97.4% Identity: 9% PDB header:proton transport Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: nmr structure of a two-transmembrane segment tm vi-vii of nhe1 Phyre2 PDB 5a1s chain B Region: 6 - 372 Aligned: 339 Modelled: 340 Confidence: 88.9% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 2l0e chain A Region: 118 - 144 Aligned: 27 Modelled: 27 Confidence: 76.4% Identity: 7% PDB header:membrane protein Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: structural and functional analysis of tm vi of the nhe1 isoform of the2 na+/h+ exchanger Phyre2 PDB 2k3c chain A Region: 227 - 254 Aligned: 28 Modelled: 28 Confidence: 14.3% Identity: 18% PDB header:metal transport Chain: A: PDB Molecule:tmix peptide; PDBTitle: structural and functional characterization of tm ix of the2 nhe1 isoform of the na+/h+ exchanger Phyre2 PDB 2m7x chain A Region: 114 - 136 Aligned: 23 Modelled: 23 Confidence: 11.3% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: structural and functional analysis of transmembrane segment iv of the2 salt tolerance protein sod2 Phyre2 PDB 4k1c chain B Region: 77 - 370 Aligned: 290 Modelled: 290 Confidence: 9.9% Identity: 10% PDB header:membrane protein/metal transport Chain: B: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 4ky0 chain B Region: 20 - 194 Aligned: 175 Modelled: 175 Confidence: 9.8% Identity: 12% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:proton/glutamate symporter, sdf family; PDBTitle: crystal structure of a substrate-free glutamate transporter homologue2 from thermococcus kodakarensis Phyre2 PDB 5oon chain A Region: 305 - 379 Aligned: 75 Modelled: 75 Confidence: 8.6% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:undecaprenyl-diphosphatase; PDBTitle: structure of undecaprenyl-pyrophosphate phosphatase, baca Phyre2 PDB 2mom chain C Region: 30 - 43 Aligned: 14 Modelled: 14 Confidence: 8.2% Identity: 21% PDB header:membrane protein Chain: C: PDB Molecule:lysosome-associated membrane glycoprotein 2; PDBTitle: structural insights of tm domain of lamp-2a in dpc micelles Phyre2 PDB 2mom chain B Region: 30 - 43 Aligned: 14 Modelled: 14 Confidence: 8.2% Identity: 21% PDB header:membrane protein Chain: B: PDB Molecule:lysosome-associated membrane glycoprotein 2; PDBTitle: structural insights of tm domain of lamp-2a in dpc micelles Phyre2 PDB 5lm4 chain A Region: 56 - 264 Aligned: 206 Modelled: 208 Confidence: 7.3% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:excitatory amino acid transporter 1,neutral amino acid PDBTitle: structure of the thermostalilized eaat1 cryst-ii mutant in complex2 with l-asp and the allosteric inhibitor ucph101 Phyre2 PDB 2nww chain A domain 1 Region: 30 - 236 Aligned: 207 Modelled: 207 Confidence: 6.8% Identity: 14% Fold: Proton glutamate symport protein Superfamily: Proton glutamate symport protein Family: Proton glutamate symport protein Phyre2 PDB 4k1c chain A Region: 77 - 370 Aligned: 290 Modelled: 290 Confidence: 6.3% Identity: 11% PDB header:membrane protein/metal transport Chain: A: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 5cbf chain A Region: 80 - 128 Aligned: 49 Modelled: 49 Confidence: 6.1% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:ion transport 2 domain protein; PDBTitle: structural and functional characterization of a calcium-activated2 cation channel from tsukamurella paurometabola Phyre2 1 c4bwzA_ 2 c5bz3A_ 3 c4czbB_ 4 c4cz8A_ 5 c1zcdA_ 6 c4n7wA_ 7 c2mdfA_ 8 c5a1sB_ 9 c2l0eA_ 10 c2k3cA_ 11 c2m7xA_ 12 c4k1cB_ 13 c4ky0B_ 14 c5oonA_ 15 c2momC_ 16 c2momB_ 17 c5lm4A_ 18 d2nwwa1 19 c4k1cA_ 20 c5cbfA_ 21 22 23 24 25 26