1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	V	K	E	V	L	L	P	G	V	G	L	R	Y	E	F	T	S	Y	R	G	D	R	I	G	I	V	A	R	R	S	G	G	F	D	V	V	L	Y	G	R	D	D	P	D	E	A	R	P	V	L	R	L	T	D	E	E	A	E
Secondary structure
SS confidence
Disorder		?	?	?			?	?																																					?			?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	A	Q	I	L	G	A	P	R	I	A	E	R	F	T	E	L	T	R	E	V	P	G	L	K	A	G	Q	I	H	I	R	A	G	S	L	F	V	D	R	P	L	G	D	T	R	A	R	T	R	T	G	A	S	I	V	A	I	V
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160
Sequence		R	D	E	D	V	L	A	S	P	G	P	T	D	V	L	R	A	G	D	V	L	I	V	I	G	T	E	D	G	I	A	G	V	E	Q	I	V	E	K	G
Secondary structure
SS confidence
Disorder																																							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 24%) Beta strand ( 40%)

Rank Aligned region

PDB 2bkn chain A Region: 56 - 160 Aligned: 105 Modelled: 105 Confidence: 99.8% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:hypothetical protein ph0236; PDBTitle: structure analysis of unknown function protein Phyre2 PDB 2fy8 chain A domain 2 Region: 74 - 159 Aligned: 86 Modelled: 86 Confidence: 99.7% Identity: 20% Fold: TrkA C-terminal domain-like Superfamily: TrkA C-terminal domain-like Family: TrkA C-terminal domain-like Phyre2 PDB 1vct chain A domain 2 Region: 73 - 159 Aligned: 87 Modelled: 87 Confidence: 99.7% Identity: 29% Fold: TrkA C-terminal domain-like Superfamily: TrkA C-terminal domain-like Family: TrkA C-terminal domain-like Phyre2 PDB 4xtt chain A Region: 71 - 157 Aligned: 85 Modelled: 87 Confidence: 99.7% Identity: 22% PDB header:transport protein Chain: A: PDB Molecule:putative potassium transport protein; PDBTitle: structural studies of potassium transport protein ktra regulator of2 conductance of k+ (rck) c domain in complex with cyclic diadenosine3 monophosphate (c-di-amp) Phyre2 PDB 2fy8 chain A Region: 50 - 158 Aligned: 109 Modelled: 109 Confidence: 99.6% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:calcium-gated potassium channel mthk; PDBTitle: crystal structure of mthk rck domain in its ligand-free gating-ring2 form Phyre2 PDB 1lnq chain C Region: 50 - 158 Aligned: 109 Modelled: 109 Confidence: 99.6% Identity: 17% PDB header:metal transport Chain: C: PDB Molecule:potassium channel related protein; PDBTitle: crystal structure of mthk at 3.3 a Phyre2 PDB 3jxo chain B Region: 74 - 159 Aligned: 83 Modelled: 86 Confidence: 99.5% Identity: 24% PDB header:transport protein Chain: B: PDB Molecule:trka-n domain protein; PDBTitle: crystal structure of an octomeric two-subunit trka k+ channel ring2 gating assembly, tm1088a:tm1088b, from thermotoga maritima Phyre2 PDB 4gx2 chain B Region: 50 - 159 Aligned: 101 Modelled: 110 Confidence: 99.5% Identity: 27% PDB header:transport protein Chain: B: PDB Molecule:trka domain protein; PDBTitle: gsuk channel bound to nad Phyre2 PDB 4g65 chain A Region: 50 - 158 Aligned: 106 Modelled: 109 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:trk system potassium uptake protein trka; PDBTitle: potassium transporter peripheral membrane component (trka) from vibrio2 vulnificus Phyre2 PDB 4j7c chain A Region: 50 - 156 Aligned: 101 Modelled: 107 Confidence: 99.4% Identity: 21% PDB header:transport protein Chain: A: PDB Molecule:ktr system potassium uptake protein a; PDBTitle: ktrab potassium transporter from bacillus subtilis Phyre2 PDB 4gvl chain B Region: 50 - 158 Aligned: 100 Modelled: 109 Confidence: 99.4% Identity: 29% PDB header:transport protein Chain: B: PDB Molecule:trka domain protein; PDBTitle: crystal structure of the gsuk rck domain Phyre2 PDB 4ys2 chain A Region: 86 - 158 Aligned: 69 Modelled: 73 Confidence: 99.4% Identity: 23% PDB header:immune system Chain: A: PDB Molecule:na+/h+ antiporter-like protein; PDBTitle: rck domain with cda Phyre2 PDB 3l4b chain G Region: 50 - 157 Aligned: 96 Modelled: 108 Confidence: 98.9% Identity: 23% PDB header:transport protein Chain: G: PDB Molecule:trka k+ channel protien tm1088b; PDBTitle: crystal structure of an octomeric two-subunit trka k+ channel ring2 gating assembly, tm1088a:tm1088b, from thermotoga maritima Phyre2 PDB 3u6n chain C Region: 50 - 149 Aligned: 100 Modelled: 100 Confidence: 98.7% Identity: 17% PDB header:transport protein Chain: C: PDB Molecule:high-conductance ca2+-activated k+ channel protein; PDBTitle: open structure of the bk channel gating ring Phyre2 PDB 4hpf chain B Region: 50 - 152 Aligned: 101 Modelled: 103 Confidence: 98.5% Identity: 15% PDB header:membrane protein, transport protein Chain: B: PDB Molecule:potassium channel subfamily u member 1; PDBTitle: structure of the human slo3 gating ring Phyre2 PDB 3mt5 chain A Region: 50 - 160 Aligned: 110 Modelled: 111 Confidence: 98.2% Identity: 15% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:potassium large conductance calcium-activated channel, PDBTitle: crystal structure of the human bk gating apparatus Phyre2 PDB 5u76 chain A Region: 51 - 146 Aligned: 96 Modelled: 96 Confidence: 98.0% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:potassium channel subfamily t member 1; PDBTitle: chicken slo2.2 in a closed conformation vitrified in the presence of2 300 mm nacl Phyre2 PDB 5a6e chain C Region: 62 - 146 Aligned: 85 Modelled: 85 Confidence: 97.9% Identity: 19% PDB header:transport Chain: C: PDB Molecule:gating ring of potassium channel subfamily t member 1; PDBTitle: cryo-em structure of the slo2.2 na-activated k channel Phyre2 PDB 5tj6 chain A Region: 51 - 160 Aligned: 110 Modelled: 110 Confidence: 97.8% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:high conductance calcium-activated potassium channel; PDBTitle: ca2+ bound aplysia slo1 Phyre2 PDB 3naf chain A Region: 50 - 146 Aligned: 95 Modelled: 97 Confidence: 97.4% Identity: 17% PDB header:ion transport Chain: A: PDB Molecule:calcium-activated potassium channel subunit alpha-1, PDBTitle: structure of the intracellular gating ring from the human high-2 conductance ca2+ gated k+ channel (bk channel) Phyre2 1 c2bknA_ 2 d2fy8a2 3 d1vcta2 4 c4xttA_ 5 c2fy8A_ 6 c1lnqC_ 7 c3jxoB_ 8 c4gx2B_ 9 c4g65A_ 10 c4j7cA_ 11 c4gvlB_ 12 c4ys2A_ 13 c3l4bG_ 14 c3u6nC_ 15 c4hpfB_ 16 c3mt5A_ 17 c5u76A_ 18 c5a6eC_ 19 c5tj6A_ 20 c3nafA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99