1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	R	Y	L	T	I	I	Y	G	A	A	S	Y	L	V	F	L	V	A	F	G	Y	A	I	G	F	V	G	D	V	V	V	P	R	T	V	D	H	A	I	A	A	P	I	G	Q	A	V	V	V	N	L	V	L	L	G	V	F	A
Secondary structure
SS confidence
Disorder		?	?	?																																		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	Q	H	S	V	M	A	R	Q	G	F	K	R	W	W	T	R	F	V	P	P	S	I	E	R	S	T	Y	V	L	L	A	S	V	A	L	L	L	L	Y	W	Q	W	R	T	M	P	A	V	I	W	D	V	R	Q	P	A	G	R	V
Secondary structure
SS confidence
Disorder																																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	L	W	A	L	F	W	L	G	W	A	T	V	L	T	S	T	F	M	I	N	H	F	E	L	F	G	L	R	Q	V	Y	L	A	W	R	G	K	P	Y	T	E	I	G	F	Q	A	H	L	L	Y	R	W	V	R	H	P	I	M	L
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	F	V	V	A	F	W	A	T	P	M	M	T	A	G	H	L	L	F	A	I	G	A	T	G	Y	I	L	V	A	L	Q	F	E	E	R	D	L	L	A	A	L	G	D	Q	Y	R	D	Y	R	R	E	V	S	M	L	L	P	W	P
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.
Sequence		H	R	H	T
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 77%) Beta strand ( 0%) TM helix ( 51%) (View membrane topology prediction)

Rank Aligned region

PDB 4a2n chain B Region: 47 - 239 Aligned: 184 Modelled: 193 Confidence: 99.9% Identity: 11% PDB header:transferase Chain: B: PDB Molecule:isoprenylcysteine carboxyl methyltransferase; PDBTitle: crystal structure of ma-icmt Phyre2 PDB 5v7p chain A Region: 125 - 242 Aligned: 118 Modelled: 118 Confidence: 99.9% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:protein-s-isoprenylcysteine o-methyltransferase; PDBTitle: atomic structure of the eukaryotic intramembrane ras methyltransferase2 icmt (isoprenylcysteine carboxyl methyltransferase), in complex with3 a monobody Phyre2 PDB 4quv chain B Region: 2 - 241 Aligned: 228 Modelled: 229 Confidence: 99.9% Identity: 12% PDB header:oxidoreductase, membrane protein Chain: B: PDB Molecule:delta(14)-sterol reductase; PDBTitle: structure of an integral membrane delta(14)-sterol reductase Phyre2 PDB 4y9i chain A Region: 214 - 238 Aligned: 24 Modelled: 25 Confidence: 57.6% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:mycobacterium tuberculosis paralogous family 11; PDBTitle: structure of f420-h2 dependent reductase (fdr-a) msmeg_2027 Phyre2 PDB 3r5y chain C Region: 216 - 238 Aligned: 22 Modelled: 23 Confidence: 37.7% Identity: 23% PDB header:unknown function Chain: C: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent nitroreductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 1kf6 chain C Region: 5 - 102 Aligned: 82 Modelled: 83 Confidence: 36.2% Identity: 17% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 3r5w chain O Region: 216 - 238 Aligned: 22 Modelled: 23 Confidence: 25.6% Identity: 23% PDB header:oxidoreductase Chain: O: PDB Molecule:deazaflavin-dependent nitroreductase; PDBTitle: structure of ddn, the deazaflavin-dependent nitroreductase from2 mycobacterium tuberculosis involved in bioreductive activation of pa-3 824, with co-factor f420 Phyre2 PDB 5e8j chain C Region: 210 - 234 Aligned: 25 Modelled: 25 Confidence: 23.8% Identity: 20% PDB header:translation Chain: C: PDB Molecule:rnmt-activating mini protein; PDBTitle: crystal structure of mrna cap guanine-n7 methyltransferase in complex2 with ram Phyre2 PDB 3h96 chain B Region: 216 - 238 Aligned: 22 Modelled: 23 Confidence: 21.7% Identity: 14% PDB header:flavoprotein Chain: B: PDB Molecule:f420-h2 dependent reductase a; PDBTitle: msmeg_3358 f420 reductase Phyre2 PDB 5c6h chain N Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 20.3% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: N: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain T Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 20.3% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: T: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain H Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 20.3% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: H: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain D Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 20.3% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: D: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain P Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 20.3% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: P: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain B Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 19.9% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: B: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain X Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 19.6% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: X: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 3r5z chain B Region: 216 - 238 Aligned: 22 Modelled: 23 Confidence: 18.8% Identity: 14% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent reductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 5c6h chain R Region: 214 - 232 Aligned: 19 Modelled: 17 Confidence: 18.1% Identity: 42% PDB header:apoptosis/apoptosis regulator Chain: R: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain L Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 16.5% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: L: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 PDB 5c6h chain F Region: 214 - 230 Aligned: 17 Modelled: 17 Confidence: 15.8% Identity: 47% PDB header:apoptosis/apoptosis regulator Chain: F: PDB Molecule:mule bh3 peptide from e3 ubiquitin-protein ligase huwe1; PDBTitle: mcl-1 complexed with mule Phyre2 1 c4a2nB_ 2 c5v7pA_ 3 c4quvB_ 4 c4y9iA_ 5 c3r5yC_ 6 d1kf6c_ 7 c3r5wO_ 8 c5e8jC_ 9 c3h96B_ 10 c5c6hN_ 11 c5c6hT_ 12 c5c6hH_ 13 c5c6hD_ 14 c5c6hP_ 15 c5c6hB_ 16 c5c6hX_ 17 c3r5zB_ 18 c5c6hR_ 19 c5c6hL_ 20 c5c6hF_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52