1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	M	S	A	Q	R	V	V	R	T	V	R	T	A	R	A	I	S	T	A	L	A	V	A	I	V	L	G	T	G	V	A	W	S	S	V	R	S	F	E	D	G	I	F	H	M	S	A	P	S	L	G	H	G	G	D	D	G	A	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	I	L	L	V	G	L	D	S	R	T	D	A	H	G	N	P	L	S	A	E	E	L	A	T	L	H	A	G	D	E	E	A	T	N	T	D	T	I	I	L	I	R	V	P	N	N	G	K	S	A	T	A	I	S	I	P	R	D	S
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	V	A	A	P	G	L	G	K	T	K	I	N	G	V	Y	G	Q	T	R	E	T	K	R	A	G	L	V	Q	A	G	A	S	P	T	E	A	A	A	A	G	T	E	A	G	R	E	A	L	I	K	T	V	A	D	L	T	G	V	T
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	D	H	Y	A	E	I	G	L	L	G	F	A	L	I	A	D	A	L	G	G	V	D	V	C	L	K	E	P	V	Y	E	P	L	S	G	A	D	F	P	A	G	R	Q	K	L	N	G	P	Q	A	L	S	F	V	R	Q	R	H	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	P	R	G	D	L	D	R	V	V	R	Q	Q	A	V	M	A	A	L	A	H	R	V	I	S	G	Q	T	L	S	S	P	A	T	L	K	R	L	E	Q	A	V	Q	R	S	V	V	L	S	S	G	W	D	I	M	D	F	V	R	Q
Secondary structure
SS confidence
Disorder				?	?	?																			?	?	?	?	?	?	?	?											?	?	?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	Q	K	L	A	G	G	N	V	A	F	A	T	I	P	V	L	D	G	A	G	W	S	D	D	G	M	Q	S	V	V	R	V	D	P	R	Q	V	Q	D	W	V	V	G	L	L	H	E	Q	D	Q	G	K	T	D	E	L	A	Y	T
Secondary structure
SS confidence
Disorder					?		?												?	?	?	?																										?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	A	K	T	T	A	N	V	V	N	D	T	D	I	N	G	L	A	A	A	V	S	K	V	L	S	S	K	G	F	T	T	G	S	V	G	N	N	D	G	D	H	V	P	G	S	Q	V	R	A	A	K	A	D	D	L	G	A	Q	Q
Secondary structure
SS confidence
Disorder		?	?											?	?	?	?																			?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	A	K	E	L	G	G	L	P	V	V	A	D	A	S	I	A	P	G	S	V	R	V	V	L	A	N	D	Y	S	G	P	G	S	G	L	G	G	S	D	P	N	G	V	V	S	P	A	R	A	F	N	L	G	S	A	D	D	T	T
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.
Sequence		P	P	P	S	P	I	L	T	A	G	S	D	A	P	E	C	I	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 36%) Alpha helix ( 30%) Beta strand ( 16%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 3pe5 chain B Region: 57 - 363 Aligned: 261 Modelled: 263 Confidence: 100.0% Identity: 25% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: three-dimensional structure of protein a7vv38_9clot from clostridium2 leptum dsm 753, northeast structural genomics consortium target3 qlr103 Phyre2 PDB 4de8 chain A Region: 49 - 345 Aligned: 251 Modelled: 254 Confidence: 100.0% Identity: 24% PDB header:membrane protein Chain: A: PDB Molecule:cps2a; PDBTitle: lytr-cps2a-psr family protein with bound octaprenyl monophosphate2 lipid Phyre2 PDB 3okz chain B Region: 57 - 364 Aligned: 261 Modelled: 269 Confidence: 100.0% Identity: 28% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative uncharacterized protein gbs0355; PDBTitle: crystal structure of protein gbs0355 from streptococcus agalactiae,2 northeast structural genomics consortium target sar127 Phyre2 PDB 5v8c chain A Region: 41 - 355 Aligned: 256 Modelled: 265 Confidence: 100.0% Identity: 26% PDB header:transcription Chain: A: PDB Molecule:transcriptional regulator; PDBTitle: lytr-csp2a-psr enzyme from actinomyces oris Phyre2 PDB 3qfi chain A Region: 56 - 354 Aligned: 234 Modelled: 249 Confidence: 100.0% Identity: 29% PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator; PDBTitle: x-ray crystal structure of transcriptional regulator (ef0465) from2 enterococcus faecalis, northeast structural genomics consortium3 target efr190 Phyre2 PDB 3owq chain B Region: 57 - 348 Aligned: 227 Modelled: 243 Confidence: 100.0% Identity: 32% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:lin1025 protein; PDBTitle: x-ray structure of lin1025 protein from listeria innocua, northeast2 structural genomics consortium target lkr164 Phyre2 PDB 3nro chain A Region: 55 - 347 Aligned: 227 Modelled: 240 Confidence: 100.0% Identity: 30% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:lmo1026 protein; PDBTitle: crystal structure of putative transcriptional factor lmo1026 from2 listeria monocytogenes (fragment 52-321), northeast structural3 genomics consortium target lmr194 Phyre2 PDB 3mej chain A Region: 41 - 347 Aligned: 235 Modelled: 258 Confidence: 100.0% Identity: 28% PDB header:transcriptional regulator Chain: A: PDB Molecule:transcriptional regulator ywtf; PDBTitle: crystal structure of putative transcriptional regulator ywtf from2 bacillus subtilis, northeast structural genomics consortium target3 sr736 Phyre2 PDB 4obm chain A Region: 59 - 348 Aligned: 232 Modelled: 239 Confidence: 100.0% Identity: 13% PDB header:transcription regulator Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative transcription regulator (eubsir_01389)2 from eubacterium siraeum dsm 15702 at 2.15 a resolution Phyre2 PDB 3nxh chain A Region: 55 - 347 Aligned: 212 Modelled: 234 Confidence: 100.0% Identity: 24% PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator yvhj; PDBTitle: crystal structure of the transcriptional regulator yvhj from bacillus2 subtilis. northeast structural genomics consortium target sr735. Phyre2 PDB 2m5y chain A Region: 347 - 446 Aligned: 100 Modelled: 100 Confidence: 99.5% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:putative tuberculin related peptide; PDBTitle: solution structure of the c-terminal domain of rv0431 Phyre2 PDB 6dfd chain B Region: 178 - 235 Aligned: 42 Modelled: 57 Confidence: 43.7% Identity: 31% PDB header:metal transport Chain: B: PDB Molecule:metal transporter cnnm3; PDBTitle: crystal structure of cnnm3 cyclic nucleotide-binding homology domain Phyre2 PDB 2pju chain D Region: 170 - 266 Aligned: 89 Modelled: 97 Confidence: 40.9% Identity: 16% PDB header:transcription Chain: D: PDB Molecule:propionate catabolism operon regulatory protein; PDBTitle: crystal structure of propionate catabolism operon regulatory protein2 prpr Phyre2 PDB 5j5v chain C Region: 232 - 264 Aligned: 33 Modelled: 33 Confidence: 40.7% Identity: 36% PDB header:toxin Chain: C: PDB Molecule:immunity protein cdii; PDBTitle: cdia-ct from uropathogenic escherichia coli in complex with cognate2 immunity protein and cysk Phyre2 PDB 3txs chain C Region: 245 - 307 Aligned: 62 Modelled: 63 Confidence: 26.5% Identity: 13% PDB header:viral protein Chain: C: PDB Molecule:terminase dna packaging enzyme small subunit; PDBTitle: crystal structure of phage 44rr small terminase gp16 Phyre2 PDB 6dj3 chain B Region: 178 - 232 Aligned: 39 Modelled: 55 Confidence: 23.5% Identity: 33% PDB header:transport protein Chain: B: PDB Molecule:metal transporter cnnm2; PDBTitle: crystal structure of cnnm2 cyclic nucleotide-binding homology domain Phyre2 PDB 1ny8 chain A Region: 245 - 265 Aligned: 21 Modelled: 21 Confidence: 10.9% Identity: 29% Fold: Alpha-lytic protease prodomain-like Superfamily: BolA-like Family: BolA-like Phyre2 PDB 2liy chain A Region: 123 - 138 Aligned: 16 Modelled: 16 Confidence: 10.1% Identity: 31% PDB header:hormone Chain: A: PDB Molecule:epidermal patterning factor-like protein 9; PDBTitle: plant peptide hormone regulating stomatal density Phyre2 PDB 6f0k chain A Region: 8 - 45 Aligned: 38 Modelled: 38 Confidence: 9.6% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c family protein; PDBTitle: alternative complex iii Phyre2 PDB 1r2j chain A domain 1 Region: 229 - 303 Aligned: 75 Modelled: 75 Confidence: 9.3% Identity: 11% Fold: Bromodomain-like Superfamily: Acyl-CoA dehydrogenase C-terminal domain-like Family: Medium chain acyl-CoA dehydrogenase-like, C-terminal domain Phyre2 1 c3pe5B_ 2 c4de8A_ 3 c3okzB_ 4 c5v8cA_ 5 c3qfiA_ 6 c3owqB_ 7 c3nroA_ 8 c3mejA_ 9 c4obmA_ 10 c3nxhA_ 11 c2m5yA_ 12 c6dfdB_ 13 c2pjuD_ 14 c5j5vC_ 15 c3txsC_ 16 c6dj3B_ 17 d1ny8a_ 18 c2liyA_ 19 c6f0kA_ 20 d1r2ja1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51