1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	E	T	T	T	E	H	R	D	E	S	T	L	D	S	P	V	S	V	A	R	E	A	E	W	Q	R	N	V	R	W	A	R	W	L	A	W	V	S	L	A	V	L	L	T	E	G	A	V	G	L	W	Q	G	I	A	V	G	S	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	L	T	G	W	A	L	G	G	G	S	E	G	L	A	S	A	M	V	L	W	R	F	T	G	D	R	T	W	S	A	T	A	E	H	R	A	Q	R	G	V	A	V	S	F	W	L	T	A	P	Y	L	V	A	E	S	I	R	H	L
Secondary structure
SS confidence
Disorder																										?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	E	H	R	A	E	T	S	V	I	G	I	G	L	T	A	I	A	L	L	L	M	P	V	L	G	W	A	N	H	R	V	G	E	R	L	G	S	G	A	T	A	G	E	G	T	Q	N	Y	L	C	A	A	Q	A	A	A	V	L
Secondary structure
SS confidence
Disorder							?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.
Sequence		L	G	L	A	I	T	A	V	W	S	N	G	W	W	I	D	P	A	I	G	L	A	I	A	G	I	A	V	W	Q	G	I	R	T	W	R	G	H	G	C	G	C
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 3j1z chain P Region: 26 - 217 Aligned: 190 Modelled: 192 Confidence: 100.0% Identity: 19% PDB header:metal transport Chain: P: PDB Molecule:cation efflux family protein; PDBTitle: inward-facing conformation of the zinc transporter yiip revealed by2 cryo-electron microscopy Phyre2 PDB 2qfi chain B Region: 30 - 218 Aligned: 187 Modelled: 189 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:ferrous-iron efflux pump fief; PDBTitle: structure of the zinc transporter yiip Phyre2 PDB 2qfi chain A domain 2 Region: 30 - 218 Aligned: 187 Modelled: 189 Confidence: 100.0% Identity: 19% Fold: Cation efflux protein transmembrane domain-like Superfamily: Cation efflux protein transmembrane domain-like Family: Cation efflux protein transmembrane domain-like Phyre2 PDB 4x9z chain A Region: 215 - 222 Aligned: 8 Modelled: 8 Confidence: 60.8% Identity: 88% PDB header:toxin Chain: A: PDB Molecule:alphad-conotoxin gexxa from the venom of conus generalis; PDBTitle: dimeric conotoxin alphad-gexxa Phyre2 PDB 3rko chain N Region: 24 - 208 Aligned: 185 Modelled: 185 Confidence: 45.7% Identity: 8% PDB header:oxidoreductase Chain: N: PDB Molecule:nadh-quinone oxidoreductase subunit n; PDBTitle: crystal structure of the membrane domain of respiratory complex i from2 e. coli at 3.0 angstrom resolution Phyre2 PDB 6hum chain B Region: 24 - 202 Aligned: 179 Modelled: 179 Confidence: 42.7% Identity: 10% PDB header:proton transport Chain: B: PDB Molecule:nad(p)h-quinone oxidoreductase subunit 2; PDBTitle: structure of the photosynthetic complex i from thermosynechococcus2 elongatus Phyre2 PDB 5m87 chain A Region: 25 - 179 Aligned: 154 Modelled: 155 Confidence: 37.2% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: crystal structure of eremococcus coleocola manganese transporter Phyre2 PDB 4x9z chain B Region: 216 - 222 Aligned: 7 Modelled: 7 Confidence: 35.4% Identity: 86% PDB header:toxin Chain: B: PDB Molecule:alphad-conotoxin gexxa from the venom of conus generalis; PDBTitle: dimeric conotoxin alphad-gexxa Phyre2 PDB 4k1c chain B Region: 4 - 164 Aligned: 159 Modelled: 161 Confidence: 28.8% Identity: 7% PDB header:membrane protein/metal transport Chain: B: PDB Molecule:vacuolar calcium ion transporter; PDBTitle: vcx1 calcium/proton exchanger Phyre2 PDB 5d92 chain B Region: 133 - 222 Aligned: 90 Modelled: 90 Confidence: 28.4% Identity: 12% PDB header:membrane protein Chain: B: PDB Molecule:af2299 protein,phosphatidylinositol synthase; PDBTitle: structure of a phosphatidylinositolphosphate (pip) synthase from2 renibacterium salmoninarum Phyre2 PDB 4he8 chain M Region: 26 - 191 Aligned: 166 Modelled: 166 Confidence: 24.8% Identity: 12% PDB header:oxidoreductase Chain: M: PDB Molecule:nadh-quinone oxidoreductase subunit 13; PDBTitle: crystal structure of the membrane domain of respiratory complex i from2 thermus thermophilus Phyre2 PDB 2l1a chain A Region: 3 - 18 Aligned: 16 Modelled: 16 Confidence: 24.1% Identity: 38% PDB header:actin binding protein Chain: A: PDB Molecule:formin-c; PDBTitle: solution nmr structure of the n-terminal gtpase-like domain of2 dictyostelium discoideum fomin c Phyre2 PDB 4o6m chain A Region: 100 - 214 Aligned: 103 Modelled: 115 Confidence: 18.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:af2299, a cdp-alcohol phosphotransferase; PDBTitle: structure of af2299, a cdp-alcohol phosphotransferase (cmp-bound) Phyre2 PDB 2jo1 chain A Region: 198 - 222 Aligned: 25 Modelled: 25 Confidence: 17.1% Identity: 40% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 2mkv chain A Region: 198 - 222 Aligned: 25 Modelled: 25 Confidence: 15.7% Identity: 24% PDB header:transport protein Chain: A: PDB Molecule:sodium/potassium-transporting atpase subunit gamma; PDBTitle: structure of the na,k-atpase regulatory protein fxyd2b in micelles Phyre2 PDB 2gc4 chain D domain 1 Region: 208 - 222 Aligned: 15 Modelled: 15 Confidence: 14.5% Identity: 20% Fold: Cytochrome c Superfamily: Cytochrome c Family: monodomain cytochrome c Phyre2 PDB 5tsa chain A Region: 73 - 175 Aligned: 101 Modelled: 103 Confidence: 14.3% Identity: 10% PDB header:metal binding protein Chain: A: PDB Molecule:membrane protein; PDBTitle: crystal structure of the zrt-/irt-like protein from bordetella2 bronchiseptica with bound zn2+ Phyre2 PDB 2jp3 chain A Region: 198 - 222 Aligned: 25 Modelled: 25 Confidence: 13.5% Identity: 28% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 5ir6 chain B Region: 19 - 158 Aligned: 140 Modelled: 140 Confidence: 13.3% Identity: 13% PDB header:oxidoreductase Chain: B: PDB Molecule:bd-type quinol oxidase subunit ii; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 4fdd chain B Region: 1 - 12 Aligned: 12 Modelled: 12 Confidence: 12.4% Identity: 33% PDB header:transport protein Chain: B: PDB Molecule:rna-binding protein fus; PDBTitle: crystal structure of kap beta2-py-nls Phyre2 1 c3j1zP_ 2 c2qfiB_ 3 d2qfia2 4 c4x9zA_ 5 c3rkoN_ 6 c6humB_ 7 c5m87A_ 8 c4x9zB_ 9 c4k1cB_ 10 c5d92B_ 11 c4he8M_ 12 c2l1aA_ 13 c4o6mA_ 14 c2jo1A_ 15 c2mkvA_ 16 d2gc4d1 17 c5tsaA_ 18 c2jp3A_ 19 c5ir6B_ 20 c4fddB_ 21 22 23 24 25 26 27 28 29 30 31