1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	E	V	T	A	G	V	R	E	L	A	T	A	I	M	V	S	R	H	L	T	G	V	L	A	G	H	G	S	Q	T	V	T	Y	H	F	A	S	I	L	C	S	S	V	H	S	L	V	V	S	F	A	D	A	T	I	A	R	L
Secondary structure
SS confidence
Disorder		?	?													?																														?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	V	V	Q	P	Y	A	Q	R	H	H	E	L	I	K	F	A	I	V	G	G	T	T	F	I	I	D	T	A	I	F	Y	T	L	K	L	T	V	L	E	P	K	P	V	T	A	K	V	I	A	G	I	V	A	V	I	A	S	Y
Secondary structure
SS confidence
Disorder		?	?																																							?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	L	N	R	E	W	S	F	R	D	R	G	G	R	E	R	H	H	E	A	L	L	F	F	A	F	S	G	V	G	V	L	L	S	M	A	P	L	W	F	S	S	Y	I	L	Q	L	R	V	P	T	V	S	L	T	M	E	N	I	A
Secondary structure
SS confidence
Disorder												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	F	I	S	A	Y	I	I	G	N	L	L	Q	M	A	F	R	F	W	A	F	R	R	W	V	F	P	D	E	F	A	R	N	P	D	K	A	L	E	S	A	L	T	A	G	G	I	A	E	V	F	E	D	V	L	E	G	G	F	E
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.
Sequence		D	G	N	V	T	L	L	R	A	W	R	N	R	A	N	R	F	A	Q	L	G	D	S	S	E	P	R	V	S	K	T	S
Secondary structure
SS confidence
Disorder										?										?	?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 72%) Beta strand ( 2%) TM helix ( 34%) (View membrane topology prediction)

Rank Aligned region

PDB 5mm1 chain A Region: 62 - 208 Aligned: 131 Modelled: 147 Confidence: 98.7% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:dolichol monophosphate mannose synthase; PDBTitle: dolichyl phosphate mannose synthase in complex with gdp and dolichyl2 phosphate mannose Phyre2 PDB 4px7 chain A Region: 108 - 220 Aligned: 86 Modelled: 94 Confidence: 85.1% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylglycerophosphatase; PDBTitle: crystal structure of lipid phosphatase e. coli pgpb Phyre2 PDB 5khn chain B Region: 78 - 199 Aligned: 109 Modelled: 122 Confidence: 26.9% Identity: 7% PDB header:membrane protein Chain: B: PDB Molecule:rnd transporter; PDBTitle: crystal structures of the burkholderia multivorans hopanoid2 transporter hpnn Phyre2 PDB 6ebu chain A Region: 104 - 199 Aligned: 66 Modelled: 75 Confidence: 26.4% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:lpxe; PDBTitle: crystal structure of aquifex aeolicus lpxe Phyre2 PDB 4rfs chain S Region: 16 - 116 Aligned: 68 Modelled: 68 Confidence: 24.4% Identity: 18% PDB header:hydrolase, transport protein Chain: S: PDB Molecule:substrate binding pritein s; PDBTitle: structure of a pantothenate energy coupling factor transporter Phyre2 PDB 4zig chain B Region: 251 - 263 Aligned: 13 Modelled: 13 Confidence: 22.5% Identity: 62% PDB header:apoptosis Chain: B: PDB Molecule:bh3-interacting domain death agonist; PDBTitle: crystal structure of core/latch dimer of bax in complex with2 bidbh3mini Phyre2 PDB 6ajj chain A Region: 106 - 231 Aligned: 103 Modelled: 126 Confidence: 16.9% Identity: 16% PDB header:membrane protein, hydrolase Chain: A: PDB Molecule:drug exporters of the rnd superfamily-like protein, PDBTitle: crystal structure of mycolic acid transporter mmpl3 from mycobacterium2 smegmatis complexed with ica38 Phyre2 PDB 4mt1 chain A Region: 77 - 199 Aligned: 113 Modelled: 123 Confidence: 15.6% Identity: 13% PDB header:membrane protein, tranport protein Chain: A: PDB Molecule:drug efflux protein; PDBTitle: crystal structure of the neisseria gonorrhoeae mtrd inner membrane2 multidrug efflux pump Phyre2 PDB 5c0v chain A Region: 194 - 201 Aligned: 8 Modelled: 8 Confidence: 15.5% Identity: 63% PDB header:rna binding protein Chain: A: PDB Molecule:la-related protein 1; PDBTitle: structure of the larp1-unique domain dm15 Phyre2 PDB 4akr chain C Region: 239 - 246 Aligned: 8 Modelled: 8 Confidence: 14.3% Identity: 88% PDB header:actin-binding protein Chain: C: PDB Molecule:f-actin-capping protein subunit alpha; PDBTitle: crystal structure of the cytoplasmic actin capping protein2 cap32_34 from dictyostelium discoideum Phyre2 PDB 1izn chain A Region: 239 - 246 Aligned: 8 Modelled: 8 Confidence: 14.1% Identity: 75% Fold: Subunits of heterodimeric actin filament capping protein Capz Superfamily: Subunits of heterodimeric actin filament capping protein Capz Family: Capz alpha-1 subunit Phyre2 PDB 1zy3 chain B Region: 251 - 263 Aligned: 13 Modelled: 13 Confidence: 12.6% Identity: 54% PDB header:apoptosis Chain: B: PDB Molecule:bh3-peptide from bh3 interacting domain death PDBTitle: structural model of complex of bcl-w protein with bid bh3-2 peptide Phyre2 PDB 6ith chain A Region: 176 - 202 Aligned: 27 Modelled: 27 Confidence: 12.4% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:syndecan-2; PDBTitle: structure of the transmembrane domain of syndecan 2 in micelles Phyre2 PDB 4z38 chain B Region: 192 - 253 Aligned: 53 Modelled: 62 Confidence: 11.9% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:mlna; PDBTitle: crystal structure of enoyl reductase domain of mlna from the2 macrolactin biosynthesis cluster from bacillus amyloliquefaciens Phyre2 PDB 6k1h chain E Region: 149 - 262 Aligned: 81 Modelled: 100 Confidence: 11.5% Identity: 22% PDB header:protein transport Chain: E: PDB Molecule:pts mannose/fructose/sorbose transporter subunit iic; PDBTitle: structure of membrane protein Phyre2 PDB 2gv5 chain C Region: 246 - 253 Aligned: 8 Modelled: 8 Confidence: 11.2% Identity: 75% PDB header:cell cycle Chain: C: PDB Molecule:sfi1p; PDBTitle: crystal structure of sfi1p/cdc31p complex Phyre2 PDB 1wpg chain A domain 4 Region: 56 - 204 Aligned: 139 Modelled: 145 Confidence: 11.1% Identity: 14% Fold: Calcium ATPase, transmembrane domain M Superfamily: Calcium ATPase, transmembrane domain M Family: Calcium ATPase, transmembrane domain M Phyre2 PDB 6fos chain K Region: 151 - 192 Aligned: 37 Modelled: 37 Confidence: 10.7% Identity: 24% PDB header:photosynthesis Chain: K: PDB Molecule:photosystem i reaction center subunit x; PDBTitle: cyanidioschyzon merolae photosystem i Phyre2 PDB 5hk1 chain A Region: 187 - 237 Aligned: 51 Modelled: 51 Confidence: 10.0% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:sigma non-opioid intracellular receptor 1; PDBTitle: human sigma-1 receptor bound to pd144418 Phyre2 PDB 2rdc chain A Region: 208 - 253 Aligned: 46 Modelled: 46 Confidence: 9.9% Identity: 30% PDB header:lipid binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative lipid binding protein (gsu0061) from2 geobacter sulfurreducens pca at 1.80 a resolution Phyre2 1 c5mm1A_ 2 c4px7A_ 3 c5khnB_ 4 c6ebuA_ 5 c4rfsS_ 6 c4zigB_ 7 c6ajjA_ 8 c4mt1A_ 9 c5c0vA_ 10 c4akrC_ 11 d1izna_ 12 c1zy3B_ 13 c6ithA_ 14 c4z38B_ 15 c6k1hE_ 16 c2gv5C_ 17 d1wpga4 18 c6fosK_ 19 c5hk1A_ 20 c2rdcA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66