1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Y	P	E	N	V	L	A	A	G	E	Q	V	V	L	H	R	H	P	H	W	N	R	L	I	W	P	V	V	V	L	V	L	L	T	G	L	A	A	F	G	S	G	F	V	N	S	T	P	W	Q	Q	I	A	K	N	V	I	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	I	W	G	I	W	L	V	I	V	G	W	L	T	L	W	P	F	L	S	W	L	T	T	H	F	V	V	T	N	R	R	V	M	F	R	H	G	V	L	T	R	S	G	I	D	I	P	L	A	R	I	N	S	V	E	F	R	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.
Sequence		R	I	F	E	R	I	F	R	T	G	T	L	I	I	E	S	A	S	Q	D	P	L	E	F	Y	N	I	P	R	L	R	E	V	H	A	L	L	Y	H	E	V	F	D	T	L	G	S	D	E	S	P	S
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 42%) Beta strand ( 31%) TM helix ( 28%) (View membrane topology prediction)

Rank Aligned region

PDB 3dcx chain A domain 1 Region: 84 - 161 Aligned: 76 Modelled: 78 Confidence: 95.2% Identity: 18% Fold: PH domain-like barrel Superfamily: PH domain-like Family: BPHL domain Phyre2 PDB 4tyz chain B Region: 86 - 160 Aligned: 71 Modelled: 75 Confidence: 92.8% Identity: 10% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the c-terminal domain of an unknown protein from2 leishmania infantum Phyre2 PDB 2hth chain B domain 1 Region: 81 - 165 Aligned: 81 Modelled: 85 Confidence: 83.8% Identity: 17% Fold: PH domain-like barrel Superfamily: PH domain-like Family: VPS36 N-terminal domain-like Phyre2 PDB 2cay chain A domain 1 Region: 81 - 125 Aligned: 45 Modelled: 45 Confidence: 83.7% Identity: 13% Fold: PH domain-like barrel Superfamily: PH domain-like Family: VPS36 N-terminal domain-like Phyre2 PDB 3fss chain A Region: 100 - 151 Aligned: 48 Modelled: 52 Confidence: 56.3% Identity: 15% PDB header:chaperone Chain: A: PDB Molecule:histone chaperone rtt106; PDBTitle: structure of the tandem ph domains of rtt106 Phyre2 PDB 3gyp chain A Region: 96 - 149 Aligned: 50 Modelled: 54 Confidence: 48.6% Identity: 12% PDB header:chaperone Chain: A: PDB Molecule:histone chaperone rtt106; PDBTitle: rtt106p Phyre2 PDB 2gcl chain A domain 1 Region: 100 - 151 Aligned: 45 Modelled: 52 Confidence: 46.6% Identity: 31% Fold: PH domain-like barrel Superfamily: PH domain-like Family: SSRP1-like Phyre2 PDB 5yqr chain A Region: 86 - 160 Aligned: 68 Modelled: 75 Confidence: 32.8% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:endolysin/membrane-anchored lipid-binding protein lam6 PDBTitle: crystal structure of the ph-like domain of lam6 Phyre2 PDB 2dx5 chain A domain 1 Region: 82 - 121 Aligned: 39 Modelled: 40 Confidence: 22.0% Identity: 18% Fold: PH domain-like barrel Superfamily: PH domain-like Family: VPS36 N-terminal domain-like Phyre2 PDB 3b77 chain A domain 1 Region: 80 - 157 Aligned: 76 Modelled: 78 Confidence: 20.2% Identity: 14% Fold: PH domain-like barrel Superfamily: PH domain-like Family: BPHL domain Phyre2 PDB 4uaq chain A Region: 130 - 171 Aligned: 42 Modelled: 42 Confidence: 14.6% Identity: 19% PDB header:protein transport Chain: A: PDB Molecule:protein translocase subunit seca 2; PDBTitle: crystal structure of the accessory translocation atpase, seca2, from2 mycobacterium tuberculosis Phyre2 PDB 1omw chain A domain 2 Region: 82 - 164 Aligned: 76 Modelled: 83 Confidence: 14.1% Identity: 16% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Pleckstrin-homology domain (PH domain) Phyre2 PDB 6irt chain A Region: 8 - 46 Aligned: 39 Modelled: 39 Confidence: 13.8% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:4f2 cell-surface antigen heavy chain; PDBTitle: human lat1-4f2hc complex bound with bch Phyre2 PDB 4r8g chain E Region: 87 - 166 Aligned: 72 Modelled: 80 Confidence: 12.8% Identity: 8% PDB header:protein binding/calcium-binding protein Chain: E: PDB Molecule:unconventional myosin-ic; PDBTitle: crystal structure of myosin-1c tail in complex with calmodulin Phyre2 PDB 4ifs chain A Region: 108 - 159 Aligned: 50 Modelled: 52 Confidence: 10.6% Identity: 20% PDB header:transcription, replication Chain: A: PDB Molecule:fact complex subunit ssrp1; PDBTitle: crystal structure of the hssrp1 middle domain Phyre2 PDB 1zj8 chain A domain 1 Region: 127 - 159 Aligned: 31 Modelled: 33 Confidence: 9.6% Identity: 19% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 3aqo chain D Region: 127 - 157 Aligned: 31 Modelled: 31 Confidence: 8.9% Identity: 13% PDB header:membrane protein Chain: D: PDB Molecule:probable secdf protein-export membrane protein; PDBTitle: structure and function of a membrane component secdf that enhances2 protein export Phyre2 PDB 1hyu chain A domain 3 Region: 131 - 172 Aligned: 38 Modelled: 42 Confidence: 7.7% Identity: 21% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: PDI-like Phyre2 PDB 4chj chain A Region: 102 - 163 Aligned: 58 Modelled: 62 Confidence: 7.2% Identity: 19% PDB header:cell cycle Chain: A: PDB Molecule:imc sub-compartment protein isp3; PDBTitle: structure of inner membrane complex (imc) sub-compartment2 protein 3 (isp3) from toxoplasma gondii Phyre2 PDB 3g9w chain A Region: 84 - 162 Aligned: 71 Modelled: 79 Confidence: 6.4% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:talin-2; PDBTitle: crystal structure of talin2 f2-f3 in complex with the integrin beta1d2 cytoplasmic tail Phyre2 1 d3dcxa1 2 c4tyzB_ 3 d2hthb1 4 d2caya1 5 c3fssA_ 6 c3gypA_ 7 d2gcla1 8 c5yqrA_ 9 d2dx5a1 10 d3b77a1 11 c4uaqA_ 12 d1omwa2 13 c6irtA_ 14 c4r8gE_ 15 c4ifsA_ 16 d1zj8a1 17 c3aqoD_ 18 d1hyua3 19 c4chjA_ 20 c3g9wA_ 21 22 23