1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	D	S	D	L	P	T	K	G	R	Q	R	G	V	R	A	V	E	L	N	V	A	A	R	L	E	N	L	A	L	L	R	T	L	V	G	A	I	G	T	F	E	D	L	D	F	D	A	V	A	D	L	R	L	A	V	D	E	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		C	T	R	L	I	R	S	A	L	P	D	A	T	L	R	L	V	V	D	P	R	K	D	E	V	V	V	E	A	S	A	A	C	D	T	H	D	V	V	A	P	G	S	F	S	W	H	V	L	T	A	L	A	D	D	V	Q	T	F	H
Secondary structure
SS confidence
Disorder								?																									?	?	?	?	?	?	?	?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.
Sequence		D	G	R	Q	P	D	V	A	G	S	V	F	G	I	T	L	T	A	R	R	A	A	S	S	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 33%) Beta strand ( 26%)

Rank Aligned region

PDB 1th8 chain A Region: 15 - 138 Aligned: 118 Modelled: 124 Confidence: 99.9% Identity: 16% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3ke6 chain A Region: 10 - 142 Aligned: 119 Modelled: 133 Confidence: 99.8% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis Phyre2 PDB 4ew8 chain A Region: 53 - 140 Aligned: 88 Modelled: 88 Confidence: 98.9% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:sensor protein divl; PDBTitle: crystal structure of a c-terminal part of tyrosine kinase (divl) from2 caulobacter crescentus cb15 at 2.50 a resolution (psi community3 target, shapiro l.) Phyre2 PDB 4gt8 chain A Region: 30 - 140 Aligned: 110 Modelled: 111 Confidence: 98.8% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:sensor protein vras; PDBTitle: crystal structure of the catalytic and atp-binding domain from vras in2 complex with adp Phyre2 PDB 4u7n chain A Region: 51 - 136 Aligned: 86 Modelled: 86 Confidence: 98.8% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:histidine protein kinase sensor protein; PDBTitle: inactive structure of histidine kinase Phyre2 PDB 3ehg chain A Region: 45 - 136 Aligned: 89 Modelled: 92 Confidence: 98.8% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp Phyre2 PDB 2c2a chain A Region: 53 - 140 Aligned: 88 Modelled: 88 Confidence: 98.7% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 3d36 chain B Region: 51 - 136 Aligned: 86 Modelled: 86 Confidence: 98.7% Identity: 14% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda Phyre2 PDB 1gjv chain A Region: 51 - 144 Aligned: 94 Modelled: 94 Confidence: 98.7% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase; PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck) complxed with2 atp-gamma-s Phyre2 PDB 3tz5 chain A Region: 51 - 138 Aligned: 88 Modelled: 88 Confidence: 98.7% Identity: 11% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, PDBTitle: crystal structure of branched-chain alpha-ketoacid dehydrogenase2 kinase/phenylbutyrate complex with adp Phyre2 PDB 3d2r chain B Region: 52 - 143 Aligned: 92 Modelled: 92 Confidence: 98.7% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 4kp4 chain B Region: 51 - 136 Aligned: 84 Modelled: 84 Confidence: 98.7% Identity: 10% PDB header:transferase/signaling protein Chain: B: PDB Molecule:osmolarity sensor protein envz, histidine kinase; PDBTitle: deciphering cis-trans directionality and visualizing2 autophosphorylation in histidine kinases. Phyre2 PDB 4r39 chain A Region: 45 - 136 Aligned: 91 Modelled: 92 Confidence: 98.6% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:blue-light-activated histidine kinase 2; PDBTitle: histidine kinase domain from erythrobacter litoralis el346 blue-light2 activated histidine kinase Phyre2 PDB 2ch4 chain A Region: 29 - 141 Aligned: 113 Modelled: 113 Confidence: 98.6% Identity: 20% PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew Phyre2 PDB 4i5s chain A Region: 50 - 136 Aligned: 87 Modelled: 87 Confidence: 98.6% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:putative histidine kinase covs; vick-like protein; PDBTitle: structure and function of sensor histidine kinase Phyre2 PDB 2bu8 chain A Region: 51 - 144 Aligned: 94 Modelled: 94 Confidence: 98.6% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 2 containing2 physiological and synthetic ligands Phyre2 PDB 1b3q chain A Region: 45 - 136 Aligned: 92 Modelled: 92 Confidence: 98.6% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase Phyre2 PDB 2c2a chain A domain 2 Region: 51 - 140 Aligned: 90 Modelled: 90 Confidence: 98.5% Identity: 10% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 2q8f chain A Region: 51 - 144 Aligned: 94 Modelled: 94 Confidence: 98.5% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 3crl chain B Region: 51 - 136 Aligned: 86 Modelled: 86 Confidence: 98.5% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:pyruvate dehydrogenase [lipoamide] kinase isozyme 2, PDBTitle: crystal structure of the pdhk2-l2 complex. Phyre2 1 d1th8a_ 2 c3ke6A_ 3 c4ew8A_ 4 c4gt8A_ 5 c4u7nA_ 6 c3ehgA_ 7 c2c2aA_ 8 c3d36B_ 9 c1gjvA_ 10 c3tz5A_ 11 c3d2rB_ 12 c4kp4B_ 13 c4r39A_ 14 c2ch4A_ 15 c4i5sA_ 16 c2bu8A_ 17 c1b3qA_ 18 d2c2aa2 19 c2q8fA_ 20 c3crlB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105