1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	E	V	G	G	P	S	R	G	D	R	L	G	R	D	D	S	E	V	H	S	A	I	R	F	A	V	V	A	A	V	V	G	V	G	F	L	I	M	G	A	L	L	V	S	T	C	S	G	V	D	T	A	A	C	G	P	P	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	I	L	L	A	L	G	G	P	L	I	L	C	A	A	G	L	W	A	F	L	R	T	Y	R	V	W	R	A	E	G	T	W	W	G	W	H	G	A	G	W	F	L	L	T	L	M	V	L	T	L	C	I	G	V	P	P	I	A	G
Secondary structure
SS confidence
Disorder																													?	?		?	?	?																				?	?		?		?	?	?
Disorder confidence
		.	.	.	.	.
Sequence		P	V	M	A	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 73%) Beta strand ( 0%) TM helix ( 28%) (View membrane topology prediction)

Rank Aligned region

PDB 3mk7 chain F Region: 62 - 119 Aligned: 57 Modelled: 58 Confidence: 28.5% Identity: 19% PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase Phyre2 PDB 5is0 chain E Region: 85 - 125 Aligned: 41 Modelled: 41 Confidence: 16.8% Identity: 12% PDB header:transport protein Chain: E: PDB Molecule:transient receptor potential cation channel subfamily v PDBTitle: structure of trpv1 in complex with capsazepine, determined in lipid2 nanodisc Phyre2 PDB 5t58 chain D Region: 78 - 87 Aligned: 10 Modelled: 10 Confidence: 14.9% Identity: 30% PDB header:cell cycle Chain: D: PDB Molecule:klla0d15741p; PDBTitle: structure of the mind complex shows a regulatory focus of yeast2 kinetochore assembly Phyre2 PDB 2mia chain A Region: 46 - 59 Aligned: 14 Modelled: 14 Confidence: 9.5% Identity: 43% PDB header:hydrolase inhibitor Chain: A: PDB Molecule:alpha amylase inhibitor; PDBTitle: solution structure of allatide c4, conformation 2 Phyre2 PDB 2k9p chain A Region: 17 - 80 Aligned: 61 Modelled: 64 Confidence: 7.9% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:pheromone alpha factor receptor; PDBTitle: structure of tm1_tm2 in lppg micelles Phyre2 PDB 1b0n chain A domain 1 Region: 84 - 91 Aligned: 8 Modelled: 8 Confidence: 6.9% Identity: 38% Fold: Dimerisation interlock Superfamily: SinR repressor dimerisation domain-like Family: SinR repressor dimerisation domain-like Phyre2 PDB 4ntj chain A Region: 55 - 115 Aligned: 57 Modelled: 61 Confidence: 6.9% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:p2y purinoceptor 12,soluble cytochrome b562,p2y PDBTitle: structure of the human p2y12 receptor in complex with an2 antithrombotic drug Phyre2 PDB 3wmm chain Y Region: 82 - 109 Aligned: 28 Modelled: 28 Confidence: 6.2% Identity: 18% PDB header:photosynthesis Chain: Y: PDB Molecule:lh1 alpha polypeptide; PDBTitle: crystal structure of the lh1-rc complex from thermochromatium tepidum2 in c2 form Phyre2 PDB 6agf chain B Region: 62 - 91 Aligned: 30 Modelled: 30 Confidence: 5.5% Identity: 10% PDB header:membrane protein Chain: B: PDB Molecule:sodium channel subunit beta-1; PDBTitle: structure of the human voltage-gated sodium channel nav1.4 in complex2 with beta1 Phyre2 PDB 2fhw chain A Region: 43 - 60 Aligned: 18 Modelled: 18 Confidence: 5.3% Identity: 17% PDB header:signaling protein Chain: A: PDB Molecule:relaxin 3 (prorelaxin h3) (insulin-like peptide PDBTitle: solution structure of human relaxin-3 Phyre2 PDB 1xme chain B domain 2 Region: 100 - 115 Aligned: 16 Modelled: 16 Confidence: 5.2% Identity: 31% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 1 c3mk7F_ 2 c5is0E_ 3 c5t58D_ 4 c2miaA_ 5 c2k9pA_ 6 d1b0na1 7 c4ntjA_ 8 c3wmmY_ 9 c6agfB_ 10 c2fhwA_ 11 d1xmeb2