1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	S	K	R	L	Q	T	G	Q	L	R	A	R	F	A	A	G	L	S	A	M	Y	A	A	E	V	P	A	Y	G	T	L	V	E	V	C	A	Q	V	N	S	D	Y	L	T	R	H	R	R	A	E	R	L	G	S	L	Q	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																																							?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	T	A	E	R	H	G	A	I	R	V	G	N	P	A	E	L	A	A	V	A	D	L	F	A	A	F	G	M	L	P	V	G	Y	Y	D	L	R	T	A	E	S	P	I	P	V	V	S	T	A	F	R	P	I	D	A	N	E	L	A
Secondary structure
SS confidence
Disorder																																							?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	N	P	F	R	V	F	T	S	M	L	A	I	E	D	R	R	Y	F	D	A	D	L	R	T	R	V	Q	T	F	L	A	R	R	Q	L	F	D	P	A	L	L	A	Q	A	R	A	I	A	A	D	G	G	C	D	A	D	D	A	P
Secondary structure
SS confidence
Disorder																	?																?		?	?	?																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	F	V	A	A	A	V	A	A	F	A	L	S	R	E	P	V	E	K	S	W	Y	D	E	L	S	R	V	S	A	V	A	A	D	I	A	G	V	G	S	T	H	I	N	H	L	T	P	R	V	L	D	I	D	D	L	Y	R	R	M
Secondary structure
SS confidence
Disorder												?	?		?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	E	R	G	I	T	M	I	D	T	I	Q	G	P	P	R	T	D	G	P	D	V	L	L	R	Q	T	S	F	R	A	L	A	E	P	R	M	F	R	D	E	D	G	T	V	T	P	G	I	L	R	V	R	F	G	E	V	E	A	R
Secondary structure
SS confidence
Disorder					?							?																					?	?					?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	V	A	L	T	P	R	G	R	E	R	Y	E	A	A	M	A	A	A	D	P	A	A	V	W	A	T	H	F	P	S	T	D	A	E	M	A	A	Q	G	L	A	Y	Y	R	G	G	D	P	S	A	P	I	V	Y	E	D	F	L	P
Secondary structure
SS confidence
Disorder				?	?	?	?													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.
Sequence		A	S	A	A	G	I	F	R	S	N	L	D	R	D	S	Q	T	G	D	G	P	D	D	A	G	Y	N	V	D	W	L	A	G	A	I	G	R	H	I	H	D	P	Y	A	L	Y	D	A	L	A	Q	E	E	R	R
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																										?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 52%) Beta strand ( 7%)

Rank Aligned region

PDB 2rjb chain D Region: 7 - 411 Aligned: 359 Modelled: 381 Confidence: 100.0% Identity: 43% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of uncharacterized protein ydcj (sf1787) from2 shigella flexneri which includes domain duf1338. northeast structural3 genomics consortium target sfr276 Phyre2 PDB 3iuz chain A Region: 7 - 300 Aligned: 265 Modelled: 294 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:putative glyoxalase superfamily protein; PDBTitle: crystal structure of putative glyoxalase superfamily protein2 (yp_299723.1) from ralstonia eutropha jmp134 at 1.90 a resolution Phyre2 PDB 3lho chain A Region: 15 - 317 Aligned: 235 Modelled: 265 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:putative hydrolase; PDBTitle: crystal structure of putative hydrolase (yp_751971.1) from shewanella2 frigidimarina ncimb 400 at 1.80 a resolution Phyre2 PDB 3rmu chain D Region: 208 - 287 Aligned: 68 Modelled: 80 Confidence: 84.8% Identity: 13% PDB header:isomerase Chain: D: PDB Molecule:methylmalonyl-coa epimerase, mitochondrial; PDBTitle: crystal structure of human methylmalonyl-coa epimerase, mcee Phyre2 PDB 1jc4 chain A Region: 219 - 287 Aligned: 54 Modelled: 69 Confidence: 74.7% Identity: 26% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Methylmalonyl-CoA epimerase Phyre2 PDB 3oa4 chain A Region: 220 - 287 Aligned: 56 Modelled: 68 Confidence: 65.7% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:glyoxalase; PDBTitle: crystal structure of hypothetical protein bh1468 from bacillus2 halodurans c-125 Phyre2 PDB 4ro6 chain A Region: 219 - 287 Aligned: 59 Modelled: 69 Confidence: 60.9% Identity: 12% PDB header:lyase Chain: A: PDB Molecule:lactoylglutathione lyase; PDBTitle: crystal structure of glyoxalase i from zea mays Phyre2 PDB 1v54 chain I Region: 356 - 369 Aligned: 14 Modelled: 14 Confidence: 60.7% Identity: 50% Fold: Single transmembrane helix Superfamily: Mitochondrial cytochrome c oxidase subunit VIc Family: Mitochondrial cytochrome c oxidase subunit VIc Phyre2 PDB 1cjx chain C Region: 219 - 246 Aligned: 28 Modelled: 28 Confidence: 60.3% Identity: 14% PDB header:oxidoreductase Chain: C: PDB Molecule:4-hydroxyphenylpyruvate dioxygenase; PDBTitle: crystal structure of pseudomonas fluorescens hppd Phyre2 PDB 3gm5 chain A Region: 220 - 257 Aligned: 38 Modelled: 38 Confidence: 58.4% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:lactoylglutathione lyase and related lyases; PDBTitle: crystal structure of a putative methylmalonyl-coenzyme a epimerase2 from thermoanaerobacter tengcongensis at 2.0 a resolution Phyre2 PDB 1sqi chain A domain 2 Region: 209 - 246 Aligned: 38 Modelled: 38 Confidence: 55.4% Identity: 26% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Extradiol dioxygenases Phyre2 PDB 1qip chain A Region: 221 - 287 Aligned: 51 Modelled: 51 Confidence: 54.0% Identity: 20% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Glyoxalase I (lactoylglutathione lyase) Phyre2 PDB 1cjx chain A domain 2 Region: 219 - 246 Aligned: 28 Modelled: 28 Confidence: 51.4% Identity: 14% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Extradiol dioxygenases Phyre2 PDB 3oaj chain A Region: 222 - 287 Aligned: 49 Modelled: 66 Confidence: 50.7% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative ring-cleaving dioxygenase mhqo; PDBTitle: crystal structure of putative dioxygenase from bacillus subtilis2 subsp. subtilis str. 168 Phyre2 PDB 1t47 chain A domain 2 Region: 209 - 246 Aligned: 38 Modelled: 38 Confidence: 50.5% Identity: 21% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Extradiol dioxygenases Phyre2 PDB 4g9q chain A Region: 133 - 311 Aligned: 158 Modelled: 179 Confidence: 48.7% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:4-carboxymuconolactone decarboxylase; PDBTitle: crystal structure of a 4-carboxymuconolactone decarboxylase Phyre2 PDB 6bu2 chain A Region: 220 - 259 Aligned: 40 Modelled: 40 Confidence: 47.1% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:glyoxalase; PDBTitle: crystal structure of methylmalonyl-coa epimerase from mycobacterium2 tuberculosis Phyre2 PDB 1t47 chain A Region: 209 - 246 Aligned: 38 Modelled: 38 Confidence: 46.7% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:4-hydroxyphenylpyruvate dioxygenase; PDBTitle: structure of fe2-hppd bound to ntbc Phyre2 PDB 2r5v chain A Region: 209 - 246 Aligned: 38 Modelled: 38 Confidence: 45.3% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:pcza361.1; PDBTitle: hydroxymandelate synthase crystal structure Phyre2 PDB 2qqz chain B Region: 219 - 265 Aligned: 44 Modelled: 47 Confidence: 44.8% Identity: 23% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:glyoxalase family protein, putative; PDBTitle: crystal structure of putative glyoxalase family protein from bacillus2 anthracis Phyre2 1 c2rjbD_ 2 c3iuzA_ 3 c3lhoA_ 4 c3rmuD_ 5 d1jc4a_ 6 c3oa4A_ 7 c4ro6A_ 8 d1v54i_ 9 c1cjxC_ 10 c3gm5A_ 11 d1sqia2 12 d1qipa_ 13 d1cjxa2 14 c3oajA_ 15 d1t47a2 16 c4g9qA_ 17 c6bu2A_ 18 c1t47A_ 19 c2r5vA_ 20 c2qqzB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99