1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	L	A	D	A	A	E	S	W	L	A	A	H	H	D	D	L	V	G	W	R	R	H	I	H	R	Y	P	E	L	G	R	Q	E	Y	A	T	T	Q	F	V	A	E	R	L	A	D	A	G	L	N	P	K	V	L	P	G	G	T
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	T	C	D	F	G	P	Q	H	Q	P	R	I	A	L	R	A	D	M	D	A	L	P	M	A	E	R	T	G	A	P	Y	A	S	T	M	P	N	V	A	H	A	C	G	H	D	A	H	T	A	I	L	L	G	A	A	L	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	S	V	P	E	L	P	V	G	V	R	L	I	F	Q	A	A	E	E	L	M	P	G	G	A	I	D	A	I	A	A	G	A	L	A	G	V	S	R	I	F	A	L	H	C	D	P	R	L	E	V	G	K	V	A	V	R	Q	G	P
Secondary structure
SS confidence
Disorder																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	T	S	A	A	D	S	I	E	I	T	L	Y	S	P	G	G	H	T	S	R	P	H	L	T	A	D	L	V	Y	G	L	G	T	L	V	T	G	L	P	G	V	L	S	R	R	I	D	P	R	N	S	T	V	L	V	W	G	A	V
Secondary structure
SS confidence
Disorder																		?			?																						?			?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	A	G	M	A	A	N	A	I	P	Q	T	G	V	L	S	G	T	V	R	T	A	S	R	Q	T	W	V	D	L	E	E	L	V	R	Q	A	I	S	A	L	L	L	P	L	A	I	E	H	T	L	Q	Y	R	R	G	V	P	P	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	N	E	E	I	S	T	R	I	L	A	H	A	I	E	A	I	G	P	G	V	L	A	D	T	R	Q	S	G	G	G	E	D	F	S	W	Y	L	E	E	V	P	G	A	M	A	R	L	G	V	W	S	G	D	G	L	Q	L	D	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.
Sequence		H	Q	P	T	F	D	I	D	E	R	A	L	A	I	G	L	R	V	M	V	N	I	I	E	Q	A	A	A	H
Secondary structure
SS confidence
Disorder																												?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 36%) Beta strand ( 24%)

Rank Aligned region

PDB 4ewt chain C Region: 3 - 387 Aligned: 385 Modelled: 385 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: C: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: the crystal structure of a putative aminohydrolase from methicillin2 resistant staphylococcus aureus Phyre2 PDB 3ram chain C Region: 4 - 389 Aligned: 358 Modelled: 365 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:hmra protein; PDBTitle: crystal structure of hmra Phyre2 PDB 2q43 chain A Region: 12 - 387 Aligned: 359 Modelled: 376 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:iaa-amino acid hydrolase ilr1-like 2; PDBTitle: ensemble refinement of the protein crystal structure of iaa-aminoacid2 hydrolase from arabidopsis thaliana gene at5g56660 Phyre2 PDB 1ysj chain B Region: 12 - 388 Aligned: 351 Modelled: 362 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:protein yxep; PDBTitle: crystal structure of bacillus subtilis yxep protein (apc1829), a2 dinuclear metal binding peptidase from m20 family Phyre2 PDB 3pfo chain B Region: 3 - 386 Aligned: 366 Modelled: 384 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:putative acetylornithine deacetylase; PDBTitle: crystal structure of a putative acetylornithine deacetylase (rpa2325)2 from rhodopseudomonas palustris cga009 at 1.90 a resolution Phyre2 PDB 3io1 chain B Region: 7 - 387 Aligned: 364 Modelled: 372 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:aminobenzoyl-glutamate utilization protein; PDBTitle: crystal structure of aminobenzoyl-glutamate utilization2 protein from klebsiella pneumoniae Phyre2 PDB 2zog chain A Region: 1 - 388 Aligned: 385 Modelled: 388 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:cytosolic non-specific dipeptidase; PDBTitle: crystal structure of mouse carnosinase cn2 complexed with zn and2 bestatin Phyre2 PDB 3dlj chain B Region: 3 - 388 Aligned: 380 Modelled: 386 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:beta-ala-his dipeptidase; PDBTitle: crystal structure of human carnosine dipeptidase 1 Phyre2 PDB 1cg2 chain D Region: 5 - 388 Aligned: 366 Modelled: 377 Confidence: 100.0% Identity: 15% PDB header:metallocarboxypeptidase Chain: D: PDB Molecule:carboxypeptidase g2; PDBTitle: carboxypeptidase g2 Phyre2 PDB 4g1p chain A Region: 4 - 387 Aligned: 381 Modelled: 384 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:cys-gly metallodipeptidase dug1; PDBTitle: structural and mechanistic basis of substrate recognition by novel di-2 peptidase dug1p from saccharomyces cerevisiae Phyre2 PDB 5k8n chain E Region: 4 - 387 Aligned: 374 Modelled: 376 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: E: PDB Molecule:5-nitroanthranilic acid aminohydrolase; PDBTitle: 5naa-bound 5-nitroanthranilate aminohydrolase Phyre2 PDB 2pok chain B Region: 2 - 386 Aligned: 377 Modelled: 385 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: crystal structure of a m20 family metallo peptidase from streptococcus2 pneumoniae Phyre2 PDB 2rb7 chain A Region: 14 - 388 Aligned: 343 Modelled: 356 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: crystal structure of co-catalytic metallopeptidase (yp_387682.1) from2 desulfovibrio desulfuricans g20 at 1.60 a resolution Phyre2 PDB 1lfw chain A Region: 1 - 388 Aligned: 372 Modelled: 388 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:pepv; PDBTitle: crystal structure of pepv Phyre2 PDB 3gb0 chain A Region: 14 - 388 Aligned: 350 Modelled: 375 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:peptidase t; PDBTitle: crystal structure of aminopeptidase pept (np_980509.1) from bacillus2 cereus atcc 10987 at 2.04 a resolution Phyre2 PDB 1vgy chain B Region: 16 - 387 Aligned: 360 Modelled: 372 Confidence: 100.0% Identity: 17% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of succinyl diaminopimelate desuccinylase Phyre2 PDB 3pfe chain A Region: 5 - 388 Aligned: 378 Modelled: 381 Confidence: 100.0% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of a m20a metallo peptidase (dape, lpg0809) from2 legionella pneumophila subsp. pneumophila str. philadelphia 1 at 1.503 a resolution Phyre2 PDB 3rza chain A Region: 14 - 389 Aligned: 352 Modelled: 376 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:tripeptidase; PDBTitle: crystal structure of a tripeptidase (sav1512) from staphylococcus2 aureus subsp. aureus mu50 at 2.10 a resolution Phyre2 PDB 3ic1 chain A Region: 15 - 387 Aligned: 357 Modelled: 371 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of zinc-bound succinyl-diaminopimelate desuccinylase2 from haemophilus influenzae Phyre2 PDB 2f7v chain A Region: 10 - 383 Aligned: 349 Modelled: 358 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:aectylcitrulline deacetylase; PDBTitle: structure of acetylcitrulline deacetylase complexed with2 one co Phyre2 1 c4ewtC_ 2 c3ramC_ 3 c2q43A_ 4 c1ysjB_ 5 c3pfoB_ 6 c3io1B_ 7 c2zogA_ 8 c3dljB_ 9 c1cg2D_ 10 c4g1pA_ 11 c5k8nE_ 12 c2pokB_ 13 c2rb7A_ 14 c1lfwA_ 15 c3gb0A_ 16 c1vgyB_ 17 c3pfeA_ 18 c3rzaA_ 19 c3ic1A_ 20 c2f7vA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160