1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	D	P	R	P	D	P	D	E	L	A	R	R	A	A	Q	V	I	A	D	R	T	G	I	G	E	H	D	V	A	V	V	L	G	S	G	W	L	P	A	V	A	A	L	G	S	P	T	T	V	L	P	Q	A	E	L	P	G	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	P	P	T	A	A	G	H	A	G	E	L	L	S	V	P	I	G	A	H	R	V	L	V	L	A	G	R	I	H	A	Y	E	G	H	D	L	R	Y	V	V	H	P	V	R	A	A	R	A	A	G	A	Q	I	M	V	L	T	N	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	G	L	R	A	D	L	Q	V	G	Q	P	V	L	I	S	D	H	L	N	L	T	A	R	S	P	L	V	G	G	E	F	V	D	L	T	D	A	Y	S	P	R	L	R	E	L	A	R	Q	S	D	P	Q	L	A	E	G	V	Y
Secondary structure
SS confidence
Disorder				?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	L	P	G	P	H	Y	E	T	P	A	E	I	R	M	L	Q	T	L	G	A	D	L	V	G	M	S	T	V	H	E	T	I	A	A	R	A	A	G	A	E	V	L	G	V	S	L	V	T	N	L	A	A	G	I	T	G	E	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.
Sequence		L	S	H	A	E	V	L	A	A	G	A	A	S	A	T	R	M	G	A	L	L	A	D	V	I	A	R	F
Secondary structure
SS confidence
Disorder																												?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 35%) Beta strand ( 19%)

Rank Aligned region

PDB 1g2o chain A Region: 7 - 268 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 100% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 4m1e chain C Region: 6 - 267 Aligned: 260 Modelled: 261 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: C: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of purine nucleoside phosphorylase i from2 planctomyces limnophilus dsm 3776, nysgrc target 029364. Phyre2 PDB 1qe5 chain A Region: 1 - 267 Aligned: 264 Modelled: 267 Confidence: 100.0% Identity: 58% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 4nsn chain C Region: 9 - 267 Aligned: 255 Modelled: 257 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: C: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of purine nucleoside phosphorylase from2 porphyromonas gingivalis atcc 33277, nysgrc target 030972,3 orthorhombic symmetry Phyre2 PDB 3bgs chain A domain 1 Region: 4 - 267 Aligned: 262 Modelled: 264 Confidence: 100.0% Identity: 39% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 1yr3 chain A Region: 13 - 267 Aligned: 254 Modelled: 255 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: A: PDB Molecule:xanthosine phosphorylase; PDBTitle: escherichia coli purine nucleoside phosphorylase ii, the product of2 the xapa gene Phyre2 PDB 5cxs chain A Region: 9 - 267 Aligned: 257 Modelled: 259 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of isoform 2 of purine nucleoside phosphorylase2 complexed with mes Phyre2 PDB 4lna chain A Region: 8 - 267 Aligned: 255 Modelled: 259 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of purine nucleoside phosphorylase i from spirosoma2 linguale dsm 74, nysgrc target 029362 Phyre2 PDB 3ggs chain A Region: 5 - 267 Aligned: 261 Modelled: 263 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: human purine nucleoside phosphorylase double mutant e201q,n243d2 complexed with 2-fluoro-2'-deoxyadenosine Phyre2 PDB 2p4s chain A Region: 7 - 267 Aligned: 259 Modelled: 261 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: structure of purine nucleoside phosphorylase from anopheles gambiae in2 complex with dadme-immh Phyre2 PDB 5ifk chain C Region: 7 - 267 Aligned: 250 Modelled: 261 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: C: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: purine nucleoside phosphorylase Phyre2 PDB 1tcv chain B Region: 9 - 267 Aligned: 249 Modelled: 259 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: B: PDB Molecule:purine-nucleoside phosphorylase; PDBTitle: crystal structure of the purine nucleoside phosphorylase2 from schistosoma mansoni in complex with non-detergent3 sulfobetaine 195 and acetate Phyre2 PDB 3pnp chain A Region: 4 - 253 Aligned: 243 Modelled: 245 Confidence: 100.0% Identity: 39% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 4uc0 chain A Region: 15 - 256 Aligned: 233 Modelled: 242 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of a purine nucleoside phosphorylase (psi-nysgrc-2 029736) from agrobacterium vitis Phyre2 PDB 1vmk chain A Region: 9 - 268 Aligned: 241 Modelled: 260 Confidence: 100.0% Identity: 39% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 3khs chain B Region: 8 - 267 Aligned: 247 Modelled: 260 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: B: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of grouper iridovirus purine nucleoside2 phosphorylase Phyre2 PDB 4glf chain A Region: 27 - 267 Aligned: 231 Modelled: 241 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:rsfp; PDBTitle: crystal structure of methylthioadenosine phosphorylase sourced from an2 antarctic soil metagenomic library Phyre2 PDB 4l5c chain E Region: 27 - 267 Aligned: 230 Modelled: 234 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: E: PDB Molecule:s-methyl-5'-thioadenosine phosphorylase; PDBTitle: methylthioadenosine phosphorylase from schistosoma mansoni in complex2 with adenine in space group p212121 Phyre2 PDB 3la8 chain A Region: 8 - 267 Aligned: 235 Modelled: 258 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:putative purine nucleoside phosphorylase; PDBTitle: the crystal structure of smu.1229 from streptococcus mutans ua159 Phyre2 PDB 1wta chain A Region: 19 - 267 Aligned: 235 Modelled: 249 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:5'-methylthioadenosine phosphorylase; PDBTitle: crystal structure of 5'-deoxy-5'-methylthioadenosine from aeropyrum2 pernix (r32 form) Phyre2 1 d1g2oa_ 2 c4m1eC_ 3 d1qe5a_ 4 c4nsnC_ 5 d3bgsa1 6 c1yr3A_ 7 c5cxsA_ 8 c4lnaA_ 9 c3ggsA_ 10 c2p4sA_ 11 c5ifkC_ 12 c1tcvB_ 13 d3pnpa_ 14 c4uc0A_ 15 d1vmka_ 16 c3khsB_ 17 c4glfA_ 18 c4l5cE_ 19 c3la8A_ 20 c1wtaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157