1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	V	E	P	D	V	E	T	L	D	P	P	L	P	P	V	P	D	G	A	V	M	V	T	V	K	I	A	R	F	N	P	D	D	P	D	A	F	A	A	T	G	G	W	Q	S	F	R	V	P	C	L	P	S	D	R	L	L	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?														?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	I	Y	I	K	G	Y	L	D	G	T	L	T	F	R	R	S	C	A	H	G	V	C	G	S	D	A	M	R	I	N	G	V	N	R	L	A	C	K	V	L	M	R	D	L	L	P	K	K	K	G	K	S	L	T	V	T	V	E
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	I	R	G	L	P	V	E	K	D	L	V	V	D	M	E	P	F	F	D	A	Y	R	A	I	K	P	Y	L	I	T	S	G	N	P	P	T	R	E	R	I	Q	S	P	T	D	R	A	R	Y	D	D	T	T	K	C	I	L	C	A
Secondary structure
SS confidence
Disorder																										?												?	?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	C	T	T	S	C	P	V	F	W	H	E	G	S	Y	F	G	P	A	A	I	V	N	A	H	R	F	I	F	D	S	R	D	E	A	A	A	E	R	L	D	I	L	N	E	V	D	G	V	W	R	C	R	T	T	F	N	C	T	E
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.
Sequence		S	C	P	R	G	I	E	V	T	K	A	I	Q	E	V	K	R	A	L	M	F	T	R
Secondary structure
SS confidence
Disorder																							?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 36%) Beta strand ( 14%)

Rank Aligned region

PDB 2h89 chain B Region: 20 - 263 Aligned: 235 Modelled: 244 Confidence: 100.0% Identity: 41% PDB header:oxidoreductase Chain: B: PDB Molecule:succinate dehydrogenase ip subunit; PDBTitle: avian respiratory complex ii with malonate bound Phyre2 PDB 5xmj chain J Region: 21 - 263 Aligned: 233 Modelled: 243 Confidence: 100.0% Identity: 29% PDB header:electron transport Chain: J: PDB Molecule:succinate dehydrogenase iron-sulfur subunit; PDBTitle: crystal structure of quinol:fumarate reductase from desulfovibrio2 gigas Phyre2 PDB 3vrb chain F Region: 22 - 261 Aligned: 231 Modelled: 234 Confidence: 100.0% Identity: 41% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: F: PDB Molecule:iron-sulfur subunit of succinate dehydrogenase; PDBTitle: mitochondrial rhodoquinol-fumarate reductase from the parasitic2 nematode ascaris suum with the specific inhibitor flutolanil and3 substrate fumarate Phyre2 PDB 2bs2 chain E Region: 21 - 261 Aligned: 232 Modelled: 241 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: E: PDB Molecule:quinol-fumarate reductase iron-sulfur subunit b; PDBTitle: quinol:fumarate reductase from wolinella succinogenes Phyre2 PDB 2b76 chain N Region: 22 - 263 Aligned: 231 Modelled: 242 Confidence: 100.0% Identity: 38% PDB header:oxidoreductase Chain: N: PDB Molecule:fumarate reductase iron-sulfur protein; PDBTitle: e. coli quinol fumarate reductase frda e49q mutation Phyre2 PDB 1nek chain B Region: 24 - 261 Aligned: 229 Modelled: 238 Confidence: 100.0% Identity: 44% PDB header:oxidoreductase/electron transport Chain: B: PDB Molecule:succinate dehydrogenase iron-sulfur protein; PDBTitle: complex ii (succinate dehydrogenase) from e. coli with2 ubiquinone bound Phyre2 PDB 2bs2 chain B domain 2 Region: 21 - 134 Aligned: 105 Modelled: 114 Confidence: 100.0% Identity: 30% Fold: beta-Grasp (ubiquitin-like) Superfamily: 2Fe-2S ferredoxin-like Family: 2Fe-2S ferredoxin domains from multidomain proteins Phyre2 PDB 1kf6 chain B domain 2 Region: 22 - 134 Aligned: 102 Modelled: 113 Confidence: 100.0% Identity: 37% Fold: beta-Grasp (ubiquitin-like) Superfamily: 2Fe-2S ferredoxin-like Family: 2Fe-2S ferredoxin domains from multidomain proteins Phyre2 PDB 1nek chain B domain 2 Region: 24 - 134 Aligned: 102 Modelled: 111 Confidence: 100.0% Identity: 41% Fold: beta-Grasp (ubiquitin-like) Superfamily: 2Fe-2S ferredoxin-like Family: 2Fe-2S ferredoxin domains from multidomain proteins Phyre2 PDB 1c4c chain A Region: 48 - 256 Aligned: 195 Modelled: 209 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:protein (fe-only hydrogenase); PDBTitle: binding of exogenously added carbon monoxide at the active2 site of the fe-only hydrogenase (cpi) from clostridium3 pasteurianum Phyre2 PDB 5xf9 chain F Region: 44 - 246 Aligned: 189 Modelled: 190 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: F: PDB Molecule:nad-reducing hydrogenase; PDBTitle: crystal structure of nad+-reducing [nife]-hydrogenase in the air-2 oxidized state Phyre2 PDB 5ldw chain G Region: 49 - 246 Aligned: 181 Modelled: 198 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-ubiquinone oxidoreductase 75 kda subunit, PDBTitle: structure of mammalian respiratory complex i, class1 Phyre2 PDB 5ldx chain G Region: 49 - 246 Aligned: 181 Modelled: 198 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-ubiquinone oxidoreductase 75 kda subunit, PDBTitle: structure of mammalian respiratory complex i, class3. Phyre2 PDB 5lnk chain 3 Region: 49 - 246 Aligned: 181 Modelled: 198 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: 3: PDB Molecule:mitochondrial complex i, 75 kda subunit; PDBTitle: entire ovine respiratory complex i Phyre2 PDB 5lc5 chain G Region: 49 - 246 Aligned: 181 Modelled: 198 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-ubiquinone oxidoreductase 75 kda subunit, PDBTitle: structure of mammalian respiratory complex i, class2 Phyre2 PDB 6gcs chain A Region: 49 - 246 Aligned: 181 Modelled: 198 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:75-kda protein (nuam); PDBTitle: cryo-em structure of respiratory complex i from yarrowia lipolytica Phyre2 PDB 2fug chain C Region: 49 - 246 Aligned: 180 Modelled: 181 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: C: PDB Molecule:nadh-quinone oxidoreductase chain 3; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus Phyre2 PDB 1kf6 chain B domain 1 Region: 135 - 261 Aligned: 127 Modelled: 127 Confidence: 99.9% Identity: 38% Fold: Globin-like Superfamily: alpha-helical ferredoxin Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Phyre2 PDB 1nek chain B domain 1 Region: 135 - 261 Aligned: 127 Modelled: 127 Confidence: 99.9% Identity: 44% Fold: Globin-like Superfamily: alpha-helical ferredoxin Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Phyre2 PDB 2bs2 chain B domain 1 Region: 136 - 260 Aligned: 125 Modelled: 125 Confidence: 99.9% Identity: 20% Fold: Globin-like Superfamily: alpha-helical ferredoxin Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Phyre2 1 c2h89B_ 2 c5xmjJ_ 3 c3vrbF_ 4 c2bs2E_ 5 c2b76N_ 6 c1nekB_ 7 d2bs2b2 8 d1kf6b2 9 d1nekb2 10 c1c4cA_ 11 c5xf9F_ 12 c5ldwG_ 13 c5ldxG_ 14 c5lnk3_ 15 c5lc5G_ 16 c6gcsA_ 17 c2fugC_ 18 d1kf6b1 19 d1nekb1 20 d2bs2b1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221