1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	P	T	G	S	R	R	I	F	S	G	V	Q	P	T	S	D	S	L	H	L	G	N	A	L	G	A	V	A	Q	W	V	G	L	Q	D	D	H	D	A	F	F	C	V	V	D	L	H	A	I	T	I	P	Q	D	P	E	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	R	R	R	T	L	I	T	A	A	Q	Y	L	A	L	G	I	D	P	G	R	A	T	I	F	V	Q	S	Q	V	P	A	H	T	Q	L	A	W	V	L	G	C	F	T	G	F	G	Q	A	S	R	M	T	Q	F	K	D	K	S	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	Q	G	S	E	A	T	T	V	G	L	F	T	Y	P	V	L	Q	A	A	D	V	L	A	Y	D	T	E	L	V	P	V	G	E	D	Q	R	Q	H	L	E	L	A	R	D	V	A	Q	R	F	N	S	R	F	P	G	T	L	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	D	V	L	I	P	K	M	T	A	K	I	Y	D	L	Q	D	P	T	S	K	M	S	K	S	A	G	T	D	A	G	L	I	N	L	L	D	D	P	A	L	S	A	K	K	I	R	S	A	V	T	D	S	E	R	D	I	R	Y	D
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	D	V	K	P	G	V	S	N	L	L	N	I	Q	S	A	V	T	G	T	D	I	D	V	L	V	D	G	Y	A	G	H	G	Y	G	D	L	K	K	D	T	A	E	A	V	V	E	F	V	N	P	I	Q	A	R	V	D	E	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.
Sequence		A	D	P	A	E	L	E	A	V	L	A	A	G	A	Q	R	A	H	D	V	A	S	K	T	V	Q	R	V	Y	D	R	L	G	F	L	L
Secondary structure
SS confidence
Disorder		?																																	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 56%) Beta strand ( 8%)

Rank Aligned region

PDB 3n9i chain A Region: 7 - 335 Aligned: 327 Modelled: 329 Confidence: 100.0% Identity: 52% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92 Phyre2 PDB 1i6l chain A Region: 8 - 335 Aligned: 324 Modelled: 328 Confidence: 100.0% Identity: 51% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 5ekd chain A Region: 7 - 335 Aligned: 326 Modelled: 328 Confidence: 100.0% Identity: 43% PDB header:ligase/antibiotic Chain: A: PDB Molecule:tryptophan--trna ligase, mitochondrial; PDBTitle: human mitochondrial tryptophanyl-trna synthetase bound by indolmycin2 and mn*atp. Phyre2 PDB 3sz3 chain A Region: 2 - 335 Aligned: 332 Modelled: 334 Confidence: 100.0% Identity: 49% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan Phyre2 PDB 3prh chain B Region: 7 - 335 Aligned: 308 Modelled: 314 Confidence: 100.0% Identity: 49% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis Phyre2 PDB 2yy5 chain C Region: 8 - 334 Aligned: 320 Modelled: 327 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae Phyre2 PDB 5tev chain A Region: 7 - 334 Aligned: 319 Modelled: 326 Confidence: 100.0% Identity: 33% PDB header:ligase Chain: A: PDB Molecule:tryptophan--trna ligase; PDBTitle: crystal structure of a tryptophanyl-trna synthetase from neisseria2 gonorrhoeae, apo Phyre2 PDB 1yi8 chain C Region: 6 - 335 Aligned: 323 Modelled: 329 Confidence: 100.0% Identity: 31% PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp Phyre2 PDB 3m5w chain B Region: 6 - 334 Aligned: 319 Modelled: 329 Confidence: 100.0% Identity: 33% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from campylobacter2 jejuni Phyre2 PDB 6mtk chain A Region: 9 - 334 Aligned: 304 Modelled: 323 Confidence: 100.0% Identity: 35% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from elizabethkingia2 anophelis nuhp1 Phyre2 PDB 2g36 chain A Region: 9 - 336 Aligned: 314 Modelled: 323 Confidence: 100.0% Identity: 34% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution Phyre2 PDB 2el7 chain A Region: 8 - 336 Aligned: 308 Modelled: 329 Confidence: 100.0% Identity: 43% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus Phyre2 PDB 6ncr chain B Region: 6 - 335 Aligned: 317 Modelled: 330 Confidence: 100.0% Identity: 32% PDB header:ligase Chain: B: PDB Molecule:tryptophan--trna ligase; PDBTitle: crystal structure of tryptophan-trna ligase from chlamydia trachomatis2 with bound l-tryptophan Phyre2 PDB 2cyc chain B Region: 5 - 309 Aligned: 302 Modelled: 305 Confidence: 100.0% Identity: 21% PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii Phyre2 PDB 3vgj chain B Region: 5 - 316 Aligned: 301 Modelled: 312 Confidence: 100.0% Identity: 17% PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase, putative; PDBTitle: crystal of plasmodium falciparum tyrosyl-trna synthetase (pftyrrs)in2 complex with adenylate analog Phyre2 PDB 2qui chain B Region: 4 - 310 Aligned: 289 Modelled: 293 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp Phyre2 PDB 2cyb chain A Region: 5 - 296 Aligned: 276 Modelled: 283 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus Phyre2 PDB 3kt3 chain D Region: 7 - 310 Aligned: 283 Modelled: 296 Confidence: 100.0% Identity: 24% PDB header:ligase Chain: D: PDB Molecule:tryptophanyl-trna synthetase, cytoplasmic; PDBTitle: crystal structure of s. cerevisiae tryptophanyl-trna synthetase in2 complex with trpamp Phyre2 PDB 3tze chain A Region: 5 - 303 Aligned: 276 Modelled: 290 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of a tryptophanyl-trna synthetase from2 encephalitozoon cuniculi bound to tryptophan Phyre2 PDB 3foc chain B Region: 4 - 310 Aligned: 287 Modelled: 307 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from giardia lamblia Phyre2 1 c3n9iA_ 2 d1i6la_ 3 c5ekdA_ 4 c3sz3A_ 5 c3prhB_ 6 c2yy5C_ 7 c5tevA_ 8 c1yi8C_ 9 c3m5wB_ 10 c6mtkA_ 11 c2g36A_ 12 c2el7A_ 13 c6ncrB_ 14 c2cycB_ 15 c3vgjB_ 16 c2quiB_ 17 c2cybA_ 18 c3kt3D_ 19 c3tzeA_ 20 c3focB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148