1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	N	A	P	K	I	K	V	S	G	P	V	V	E	L	D	G	D	E	M	T	R	V	I	W	K	L	I	K	D	M	L	I	L	P	Y	L	D	I	R	L	D	Y	Y	D	L	G	I	E	H	R	D	A	T	D	D	Q	V	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	D	A	A	Y	A	I	K	K	H	G	V	G	V	K	C	A	T	I	T	P	D	E	A	R	V	E	E	F	N	L	K	K	M	W	L	S	P	N	G	T	I	R	N	I	L	G	G	T	I	F	R	E	P	I	V	I	S	N	V
Secondary structure
SS confidence
Disorder																						?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	R	L	V	P	G	W	T	K	P	I	V	I	G	R	H	A	F	G	D	Q	Y	R	A	T	N	F	K	V	D	Q	P	G	T	V	T	L	T	F	T	P	A	D	G	S	A	P	I	V	H	E	M	V	S	I	P	E	D	G	G
Secondary structure
SS confidence
Disorder			?	?	?																																						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	V	L	G	M	Y	N	F	K	E	S	I	R	D	F	A	R	A	S	F	S	Y	G	L	N	A	K	W	P	V	Y	L	S	T	K	N	T	I	L	K	A	Y	D	G	M	F	K	D	E	F	E	R	V	Y	E	E	E	F	K	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	F	E	A	A	G	L	T	Y	E	H	R	L	I	D	D	M	V	A	A	C	L	K	W	E	G	G	Y	V	W	A	C	K	N	Y	D	G	D	V	Q	S	D	T	V	A	Q	G	Y	G	S	L	G	L	M	T	S	V	L	M	T
Secondary structure
SS confidence
Disorder																																																		?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	D	G	K	T	V	E	A	E	A	A	H	G	T	V	T	R	H	Y	R	Q	Y	Q	A	G	K	P	T	S	T	N	P	I	A	S	I	F	A	W	T	R	G	L	Q	H	R	G	K	L	D	G	T	P	E	V	I	D	F	A	H
Secondary structure
SS confidence
Disorder																					?				?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.
Sequence		K	L	E	S	V	V	I	A	T	V	E	S	G	K	M	T	K	D	L	A	I	L	I	G	P	E	Q	D	W	L	N	S	E	E	F	L	D	A	I	A	D	N	L	E	K	E	L	A	N
Secondary structure
SS confidence
Disorder																										?	?	?	?																			?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 41%) Beta strand ( 18%)

Rank Aligned region

PDB 3us8 chain A Region: 6 - 405 Aligned: 398 Modelled: 400 Confidence: 100.0% Identity: 72% PDB header:oxidoreductase Chain: A: PDB Molecule:isocitrate dehydrogenase [nadp]; PDBTitle: crystal structure of an isocitrate dehydrogenase from sinorhizobium2 meliloti 1021 Phyre2 PDB 2qfy chain E Region: 3 - 409 Aligned: 406 Modelled: 407 Confidence: 100.0% Identity: 62% PDB header:oxidoreductase Chain: E: PDB Molecule:isocitrate dehydrogenase [nadp]; PDBTitle: crystal structure of saccharomyces cerevesiae mitochondrial nadp(+)-2 dependent isocitrate dehydrogenase in complex with a-ketoglutarate Phyre2 PDB 1t0l chain A Region: 5 - 407 Aligned: 403 Modelled: 403 Confidence: 100.0% Identity: 66% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 1lwd chain A Region: 3 - 407 Aligned: 404 Modelled: 405 Confidence: 100.0% Identity: 66% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 2uxq chain B Region: 6 - 405 Aligned: 397 Modelled: 400 Confidence: 100.0% Identity: 51% PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase native; PDBTitle: isocitrate dehydrogenase from the psychrophilic bacterium2 desulfotalea psychrophila: biochemical properties and3 crystal structure analysis Phyre2 PDB 1zor chain B Region: 7 - 407 Aligned: 389 Modelled: 401 Confidence: 100.0% Identity: 55% PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase; PDBTitle: isocitrate dehydrogenase from the hyperthermophile thermotoga maritima Phyre2 PDB 4aoy chain D Region: 5 - 405 Aligned: 373 Modelled: 387 Confidence: 100.0% Identity: 53% PDB header:oxidoreductase Chain: D: PDB Molecule:isocitrate dehydrogenase [nadp]; PDBTitle: open ctidh. the complex structures of isocitrate dehydrogenase from2 clostridium thermocellum and desulfotalea psychrophila, support a new3 active site locking mechanism Phyre2 PDB 1hqs chain A Region: 1 - 404 Aligned: 376 Modelled: 404 Confidence: 100.0% Identity: 23% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 2d4v chain D Region: 8 - 403 Aligned: 367 Modelled: 396 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: D: PDB Molecule:isocitrate dehydrogenase; PDBTitle: crystal structure of nad dependent isocitrate dehydrogenase2 from acidithiobacillus thiooxidans Phyre2 PDB 2d1c chain B Region: 1 - 407 Aligned: 337 Modelled: 380 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase; PDBTitle: crystal structure of tt0538 protein from thermus thermophilus hb8 Phyre2 PDB 3fmx chain X Region: 10 - 405 Aligned: 346 Modelled: 373 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: X: PDB Molecule:tartrate dehydrogenase/decarboxylase; PDBTitle: crystal structure of tartrate dehydrogenase from pseudomonas putida2 complexed with nadh Phyre2 PDB 1pb1 chain A Region: 2 - 403 Aligned: 373 Modelled: 396 Confidence: 100.0% Identity: 22% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 2e0c chain A Region: 1 - 405 Aligned: 364 Modelled: 388 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:409aa long hypothetical nadp-dependent isocitrate PDBTitle: crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii2 strain7 at 2.0 a resolution Phyre2 PDB 1v53 chain A domain 1 Region: 9 - 403 Aligned: 343 Modelled: 371 Confidence: 100.0% Identity: 19% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 1cnz chain A Region: 5 - 407 Aligned: 349 Modelled: 378 Confidence: 100.0% Identity: 20% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 1cm7 chain A Region: 8 - 407 Aligned: 349 Modelled: 377 Confidence: 100.0% Identity: 19% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 3udu chain G Region: 10 - 407 Aligned: 339 Modelled: 370 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: G: PDB Molecule:3-isopropylmalate dehydrogenase; PDBTitle: crystal structure of putative 3-isopropylmalate dehydrogenase from2 campylobacter jejuni Phyre2 PDB 3u1h chain A Region: 11 - 408 Aligned: 339 Modelled: 367 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:3-isopropylmalate dehydrogenase; PDBTitle: crystal structure of ipmdh from the last common ancestor of bacillus Phyre2 PDB 1vlc chain A Region: 8 - 405 Aligned: 342 Modelled: 371 Confidence: 100.0% Identity: 22% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 3vl3 chain A Region: 10 - 407 Aligned: 344 Modelled: 375 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:3-isopropylmalate dehydrogenase; PDBTitle: 3-isopropylmalate dehydrogenase from shewanella oneidensis mr-1 at 3402 mpa Phyre2 1 c3us8A_ 2 c2qfyE_ 3 d1t0la_ 4 d1lwda_ 5 c2uxqB_ 6 c1zorB_ 7 c4aoyD_ 8 d1hqsa_ 9 c2d4vD_ 10 c2d1cB_ 11 c3fmxX_ 12 d1pb1a_ 13 c2e0cA_ 14 d1v53a1 15 d1cnza_ 16 d1cm7a_ 17 c3uduG_ 18 c3u1hA_ 19 d1vlca_ 20 c3vl3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99