1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	I	S	A	S	E	A	R	Q	R	L	F	P	L	I	E	Q	V	N	T	D	H	Q	P	V	R	I	T	S	R	A	G	D	A	V	L	M	S	A	D	D	Y	D	A	W	Q	E	T	V	Y	L	L	R	S	P	E	N	A	R
Secondary structure
SS confidence
Disorder		?	?	?	?																																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
Sequence		R	L	M	E	A	V	A	R	D	K	A	G	H	S	A	F	T	K	S	V	D	E	L	R	E	M	A	G	G	E	E
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 58%) Beta strand ( 12%)

Rank Aligned region

PDB 3oei chain B Region: 1 - 91 Aligned: 91 Modelled: 91 Confidence: 100.0% Identity: 100% PDB header:toxin, protein binding Chain: B: PDB Molecule:relj (antitoxin rv3357); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) Phyre2 PDB 3d55 chain A Region: 1 - 68 Aligned: 68 Modelled: 68 Confidence: 99.9% Identity: 100% PDB header:toxin inhibitor Chain: A: PDB Molecule:uncharacterized protein rv3357/mt3465; PDBTitle: crystal structure of m. tuberculosis yefm antitoxin Phyre2 PDB 2a6q chain A domain 1 Region: 2 - 81 Aligned: 80 Modelled: 80 Confidence: 99.9% Identity: 44% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 3g5o chain A Region: 2 - 91 Aligned: 87 Modelled: 90 Confidence: 99.9% Identity: 28% PDB header:toxin/antitoxin Chain: A: PDB Molecule:uncharacterized protein rv2865; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis Phyre2 PDB 2a6q chain B domain 1 Region: 2 - 53 Aligned: 52 Modelled: 52 Confidence: 99.7% Identity: 46% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 3hs2 chain H Region: 2 - 51 Aligned: 49 Modelled: 50 Confidence: 99.5% Identity: 29% PDB header:antitoxin Chain: H: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd truncated to residue 57 in an orthorhombic2 space group Phyre2 PDB 3hry chain A Region: 2 - 49 Aligned: 47 Modelled: 48 Confidence: 99.3% Identity: 30% PDB header:antitoxin Chain: A: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd in a trigonal space group and partially2 disordered Phyre2 PDB 2odk chain D Region: 2 - 49 Aligned: 47 Modelled: 48 Confidence: 99.0% Identity: 19% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein; PDBTitle: putative prevent-host-death protein from nitrosomonas europaea Phyre2 PDB 2odk chain A domain 1 Region: 2 - 49 Aligned: 47 Modelled: 48 Confidence: 98.9% Identity: 17% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 3k6q chain B Region: 2 - 49 Aligned: 47 Modelled: 48 Confidence: 95.4% Identity: 19% PDB header:ligand binding protein Chain: B: PDB Molecule:putative ligand binding protein; PDBTitle: crystal structure of an antitoxin part of a putative toxin/antitoxin2 system (swol_0700) from syntrophomonas wolfei subsp. wolfei at 1.80 a3 resolution Phyre2 PDB 5ytp chain A Region: 36 - 87 Aligned: 51 Modelled: 52 Confidence: 53.0% Identity: 22% PDB header:dna binding protein Chain: A: PDB Molecule:ttha0139; PDBTitle: crystal structure of ttha0139 l34a from thermus thermophilus hb8 Phyre2 PDB 4q2u chain M Region: 60 - 89 Aligned: 30 Modelled: 30 Confidence: 39.7% Identity: 20% PDB header:toxin/toxin repressor Chain: M: PDB Molecule:antitoxin dinj; PDBTitle: crystal structure of the e. coli dinj-yafq toxin-antitoxin complex Phyre2 PDB 1n0e chain A Region: 6 - 91 Aligned: 73 Modelled: 86 Confidence: 34.5% Identity: 14% Fold: Double-split beta-barrel Superfamily: AbrB/MazE/MraZ-like Family: Hypothetical protein MraZ Phyre2 PDB 3ia7 chain A Region: 31 - 88 Aligned: 57 Modelled: 58 Confidence: 34.3% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:calg4; PDBTitle: crystal structure of calg4, the calicheamicin glycosyltransferase Phyre2 PDB 1n0f chain F Region: 6 - 91 Aligned: 73 Modelled: 86 Confidence: 33.4% Identity: 14% PDB header:biosynthetic protein Chain: F: PDB Molecule:protein mraz; PDBTitle: crystal structure of a cell division and cell wall2 biosynthesis protein upf0040 from mycoplasma pneumoniae:3 indication of a novel fold with a possible new conserved4 sequence motif Phyre2 PDB 4q8j chain E Region: 3 - 51 Aligned: 47 Modelled: 49 Confidence: 33.2% Identity: 11% PDB header:hydrolase Chain: E: PDB Molecule:pab-dependent poly(a)-specific ribonuclease subunit pan3; PDBTitle: structure of the saccharomyces cerevisiae pan2-pan3 core complex Phyre2 PDB 4cyi chain H Region: 3 - 51 Aligned: 47 Modelled: 49 Confidence: 31.7% Identity: 9% PDB header:transferase Chain: H: PDB Molecule:pab-dependent poly(a)-specific ribonuclease subunit pan3- PDBTitle: chaetomium thermophilum pan3 Phyre2 PDB 6r5k chain O Region: 3 - 51 Aligned: 47 Modelled: 49 Confidence: 30.8% Identity: 11% PDB header:rna binding protein Chain: O: PDB Molecule:pan2-pan3 deadenylation complex subunit pan3; PDBTitle: cryo-em structure of a poly(a) rnp bound to the pan2-pan3 deadenylase Phyre2 PDB 1grj chain A domain 1 Region: 36 - 67 Aligned: 32 Modelled: 32 Confidence: 28.1% Identity: 25% Fold: Long alpha-hairpin Superfamily: GreA transcript cleavage protein, N-terminal domain Family: GreA transcript cleavage protein, N-terminal domain Phyre2 PDB 6nkl chain D Region: 22 - 61 Aligned: 40 Modelled: 40 Confidence: 25.2% Identity: 13% PDB header:antitoxin Chain: D: PDB Molecule:antitoxin vapb1; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 1 c3oeiB_ 2 c3d55A_ 3 d2a6qa1 4 c3g5oA_ 5 d2a6qb1 6 c3hs2H_ 7 c3hryA_ 8 c2odkD_ 9 d2odka1 10 c3k6qB_ 11 c5ytpA_ 12 c4q2uM_ 13 d1n0ea_ 14 c3ia7A_ 15 c1n0fF_ 16 c4q8jE_ 17 c4cyiH_ 18 c6r5kO_ 19 d1grja1 20 c6nklD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99