1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	S	V	N	F	D	P	D	A	W	E	D	F	L	F	W	L	A	A	D	R	K	T	A	R	R	I	T	R	L	I	G	E	I	Q	R	D	P	F	S	G	I	G	K	P	E	P	L	Q	G	E	L	S	G	Y	W	S	R	R
Secondary structure
SS confidence
Disorder		?	?																																						?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.
Sequence		I	D	D	E	H	R	L	V	Y	R	A	G	D	D	E	V	T	M	L	K	A	R	Y	H	Y
Secondary structure
SS confidence
Disorder																								?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 34%) Beta strand ( 31%)

Rank Aligned region

PDB 3oei chain H Region: 1 - 85 Aligned: 85 Modelled: 85 Confidence: 100.0% Identity: 100% PDB header:toxin, protein binding Chain: H: PDB Molecule:relk (toxin rv3358); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) Phyre2 PDB 2a6s chain A domain 1 Region: 3 - 84 Aligned: 82 Modelled: 82 Confidence: 100.0% Identity: 45% Fold: RelE-like Superfamily: RelE-like Family: YoeB/Txe-like Phyre2 PDB 4q2u chain H Region: 1 - 84 Aligned: 84 Modelled: 84 Confidence: 99.9% Identity: 18% PDB header:toxin/toxin repressor Chain: H: PDB Molecule:mrna interferase yafq; PDBTitle: crystal structure of the e. coli dinj-yafq toxin-antitoxin complex Phyre2 PDB 1z8m chain A domain 1 Region: 1 - 84 Aligned: 83 Modelled: 84 Confidence: 99.9% Identity: 20% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 2otr chain A Region: 1 - 84 Aligned: 84 Modelled: 84 Confidence: 99.9% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hp0892; PDBTitle: solution structure of conserved hypothetical protein hp0892 from2 helicobacter pylori Phyre2 PDB 2khe chain A Region: 2 - 84 Aligned: 79 Modelled: 83 Confidence: 99.4% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:toxin-like protein; PDBTitle: solution structure of the bacterial toxin rele from thermus2 thermophilus hb8 Phyre2 PDB 3bpq chain D Region: 4 - 84 Aligned: 76 Modelled: 81 Confidence: 99.3% Identity: 17% PDB header:toxin Chain: D: PDB Molecule:toxin rele3; PDBTitle: crystal structure of relb-rele antitoxin-toxin complex from2 methanococcus jannaschii Phyre2 PDB 1wmi chain A domain 1 Region: 2 - 84 Aligned: 79 Modelled: 83 Confidence: 99.2% Identity: 15% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 3g5o chain C Region: 2 - 83 Aligned: 75 Modelled: 82 Confidence: 99.2% Identity: 27% PDB header:toxin/antitoxin Chain: C: PDB Molecule:uncharacterized protein rv2866; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis Phyre2 PDB 3kix chain Y Region: 2 - 83 Aligned: 76 Modelled: 76 Confidence: 98.6% Identity: 18% PDB header:ribosome Chain: Y: PDB Molecule: PDBTitle: structure of rele nuclease bound to the 70s ribosome (postcleavage2 state; part 3 of 4) Phyre2 PDB 4mct chain D Region: 21 - 81 Aligned: 61 Modelled: 61 Confidence: 98.5% Identity: 23% PDB header:toxin Chain: D: PDB Molecule:killer protein; PDBTitle: p. vulgaris higba structure, crystal form 1 Phyre2 PDB 5cw7 chain H Region: 3 - 83 Aligned: 76 Modelled: 81 Confidence: 98.0% Identity: 13% PDB header:toxin Chain: H: PDB Molecule:plasmid stabilization protein pare; PDBTitle: crystal structure of the paaa2-pare2 antitoxin-toxin complex Phyre2 PDB 5ceg chain B Region: 2 - 83 Aligned: 77 Modelled: 82 Confidence: 97.9% Identity: 18% PDB header:toxin Chain: B: PDB Molecule:plasmid stabilization system; PDBTitle: x-ray structure of toxin/anti-toxin complex from mesorhizobium2 opportunistum Phyre2 PDB 3kxe chain B Region: 2 - 83 Aligned: 76 Modelled: 78 Confidence: 97.7% Identity: 21% PDB header:protein binding Chain: B: PDB Molecule:toxin protein pare-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex Phyre2 PDB 5ja9 chain D Region: 3 - 83 Aligned: 71 Modelled: 76 Confidence: 95.8% Identity: 18% PDB header:toxin Chain: D: PDB Molecule:toxin higb-2; PDBTitle: crystal structure of the higb2 toxin in complex with nb6 Phyre2 PDB 6f8s chain D Region: 41 - 81 Aligned: 36 Modelled: 41 Confidence: 95.7% Identity: 17% PDB header:toxin Chain: D: PDB Molecule:putative killer protein; PDBTitle: toxin-antitoxin complex grata Phyre2 PDB 3e9v chain A domain 1 Region: 15 - 63 Aligned: 47 Modelled: 49 Confidence: 39.3% Identity: 17% Fold: BTG domain-like Superfamily: BTG domain-like Family: BTG domain-like Phyre2 PDB 2lo0 chain B Region: 2 - 34 Aligned: 33 Modelled: 33 Confidence: 32.6% Identity: 27% PDB header:protein binding Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of the get5 carboxyl domain from a. fumigatus Phyre2 PDB 2z15 chain A domain 1 Region: 21 - 63 Aligned: 41 Modelled: 43 Confidence: 26.9% Identity: 17% Fold: BTG domain-like Superfamily: BTG domain-like Family: BTG domain-like Phyre2 PDB 1khb chain A domain 2 Region: 40 - 85 Aligned: 43 Modelled: 46 Confidence: 23.6% Identity: 26% Fold: PEP carboxykinase N-terminal domain Superfamily: PEP carboxykinase N-terminal domain Family: PEP carboxykinase N-terminal domain Phyre2 1 c3oeiH_ 2 d2a6sa1 3 c4q2uH_ 4 d1z8ma1 5 c2otrA_ 6 c2kheA_ 7 c3bpqD_ 8 d1wmia1 9 c3g5oC_ 10 c3kixy_ 11 c4mctD_ 12 c5cw7H_ 13 c5cegB_ 14 c3kxeB_ 15 c5ja9D_ 16 c6f8sD_ 17 d3e9va1 18 c2lo0B_ 19 d2z15a1 20 d1khba2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53