1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	A	R	L	P	D	S	P	L	D	W	L	V	S	K	F	A	R	E	V	P	G	V	A	H	A	L	L	V	S	V	D	G	L	P	V	A	A	S	E	H	L	P	R	E	R	A	D	Q	L	A	A	V	T	S	G	L	A	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																														?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	G	G	A	A	Q	L	F	D	G	G	Q	V	L	Q	S	V	V	E	M	Q	N	G	Y	L	L	L	M	Q	V	G	D	G	S	A	L	A	A	L	A	A	T	G	C	D	I	G	Q	I	G	Y	E	M	A	I	L	V	E	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130
Sequence		V	G	G	V	V	Q	S	C	R	R
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 40%) Beta strand ( 27%)

Rank Aligned region

PDB 3kye chain C Region: 9 - 127 Aligned: 118 Modelled: 119 Confidence: 100.0% Identity: 41% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:roadblock/lc7 domain, robl_lc7; PDBTitle: crystal structure of roadblock/lc7 domain from streptomyces2 avermitilis Phyre2 PDB 1j3w chain A Region: 6 - 128 Aligned: 122 Modelled: 123 Confidence: 99.9% Identity: 18% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 1j3w chain B Region: 6 - 128 Aligned: 122 Modelled: 123 Confidence: 99.9% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:giding protein-mglb; PDBTitle: structure of gliding protein-mglb from thermus thermophilus hb8 Phyre2 PDB 3leq chain A Region: 8 - 121 Aligned: 101 Modelled: 114 Confidence: 99.9% Identity: 39% PDB header:structure genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein cvnb5; PDBTitle: the crystal structure of the roadblock/lc7 domain from streptomyces2 avermitillis to 1.85a Phyre2 PDB 1vet chain B Region: 5 - 123 Aligned: 115 Modelled: 119 Confidence: 99.9% Identity: 20% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 3cpt chain A domain 1 Region: 8 - 126 Aligned: 116 Modelled: 119 Confidence: 99.2% Identity: 12% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 1sko chain A Region: 8 - 126 Aligned: 116 Modelled: 117 Confidence: 99.2% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:mitogen-activated protein kinase kinase 1 PDBTitle: mp1-p14 complex Phyre2 PDB 1y4o chain A domain 1 Region: 9 - 103 Aligned: 91 Modelled: 95 Confidence: 98.4% Identity: 11% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 2hz5 chain A domain 1 Region: 11 - 103 Aligned: 86 Modelled: 93 Confidence: 98.1% Identity: 12% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 6ehr chain D Region: 18 - 98 Aligned: 78 Modelled: 81 Confidence: 96.7% Identity: 23% PDB header:signaling protein Chain: D: PDB Molecule:ragulator complex protein lamtor4; PDBTitle: the crystal structure of the human lamtor-raga ctd-ragc ctd complex Phyre2 PDB 3ms6 chain A Region: 6 - 104 Aligned: 90 Modelled: 98 Confidence: 96.7% Identity: 22% PDB header:protein binding Chain: A: PDB Molecule:hepatitis b virus x-interacting protein; PDBTitle: crystal structure of hepatitis b x-interacting protein (hbxip) Phyre2 PDB 1acf chain A Region: 14 - 128 Aligned: 110 Modelled: 115 Confidence: 90.9% Identity: 17% Fold: Profilin-like Superfamily: Profilin (actin-binding protein) Family: Profilin (actin-binding protein) Phyre2 PDB 1ypr chain A Region: 11 - 128 Aligned: 111 Modelled: 118 Confidence: 87.1% Identity: 15% Fold: Profilin-like Superfamily: Profilin (actin-binding protein) Family: Profilin (actin-binding protein) Phyre2 PDB 1g5u chain A Region: 21 - 123 Aligned: 102 Modelled: 103 Confidence: 85.6% Identity: 18% Fold: Profilin-like Superfamily: Profilin (actin-binding protein) Family: Profilin (actin-binding protein) Phyre2 PDB 1f2k chain A Region: 14 - 123 Aligned: 109 Modelled: 110 Confidence: 84.3% Identity: 14% Fold: Profilin-like Superfamily: Profilin (actin-binding protein) Family: Profilin (actin-binding protein) Phyre2 PDB 3nul chain A Region: 14 - 123 Aligned: 110 Modelled: 110 Confidence: 79.3% Identity: 14% Fold: Profilin-like Superfamily: Profilin (actin-binding protein) Family: Profilin (actin-binding protein) Phyre2 PDB 3dav chain A Region: 14 - 127 Aligned: 109 Modelled: 114 Confidence: 77.2% Identity: 15% PDB header:protein binding Chain: A: PDB Molecule:profilin; PDBTitle: schizosaccharomyces pombe profilin crystallized from sodium formate Phyre2 PDB 5o7j chain A Region: 8 - 42 Aligned: 34 Modelled: 35 Confidence: 76.9% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:histidine kinase; PDBTitle: structural insights into the periplasmic sensor domain of the gacs2 histidine kinase controlling biofilm formation in pseudomonas3 aeruginosa Phyre2 PDB 1cqa chain A Region: 11 - 123 Aligned: 108 Modelled: 113 Confidence: 74.4% Identity: 17% Fold: Profilin-like Superfamily: Profilin (actin-binding protein) Family: Profilin (actin-binding protein) Phyre2 PDB 4xtb chain A Region: 7 - 41 Aligned: 35 Modelled: 35 Confidence: 60.4% Identity: 26% PDB header:transport protein Chain: A: PDB Molecule:calcium uniporter protein, mitochondrial; PDBTitle: crystal structure of the n-terminal domain of the human mitochondrial2 calcium uniporter Phyre2 1 c3kyeC_ 2 d1j3wa_ 3 c1j3wB_ 4 c3leqA_ 5 d1vetb_ 6 d3cpta1 7 c1skoA_ 8 d1y4oa1 9 d2hz5a1 10 c6ehrD_ 11 c3ms6A_ 12 d1acfa_ 13 d1ypra_ 14 d1g5ua_ 15 d1f2ka_ 16 d3nula_ 17 c3davA_ 18 c5o7jA_ 19 d1cqaa_ 20 c4xtbA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99