1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	R	L	L	F	V	S	P	R	I	A	P	N	T	G	N	A	I	R	T	C	A	A	T	G	C	E	L	H	L	V	E	P	L	G	F	D	L	S	E	P	K	L	R	R	A	G	L	D	Y	H	D	L	A	S	V	T	V	H
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	S	L	A	H	A	W	E	A	L	S	P	A	R	V	F	A	F	T	A	Q	A	T	T	L	F	T	N	V	G	Y	R	A	G	D	V	L	M	F	G	P	E	P	T	G	L	D	E	A	T	L	A	D	T	H	I	T	G	Q	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.
Sequence		R	I	P	M	L	A	G	R	R	S	L	N	L	S	N	A	A	A	V	A	V	Y	E	A	W	R	Q	H	G	F	A	G	A	V
Secondary structure
SS confidence
Disorder																															?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 36%) Beta strand ( 21%) TM helix ( 10%) (View membrane topology prediction)

Rank Aligned region

PDB 1mxi chain A Region: 1 - 154 Aligned: 154 Modelled: 154 Confidence: 100.0% Identity: 47% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 4pzk chain A Region: 2 - 152 Aligned: 149 Modelled: 151 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: crystal strucrure of putative rna methyltransferase from bacillus2 anthracis. Phyre2 PDB 1gz0 chain H Region: 2 - 149 Aligned: 146 Modelled: 139 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: H: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 5co4 chain A Region: 1 - 149 Aligned: 146 Modelled: 146 Confidence: 100.0% Identity: 49% PDB header:transferase Chain: A: PDB Molecule:putative trna (cytidine(34)-2'-o)-methyltransferase; PDBTitle: structural insights into the 2-oh methylation of c/u34 on trna Phyre2 PDB 1x7p chain B Region: 2 - 148 Aligned: 145 Modelled: 145 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet Phyre2 PDB 4x3m chain B Region: 2 - 153 Aligned: 147 Modelled: 147 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: B: PDB Molecule:rna 2'-o ribose methyltransferase; PDBTitle: crystal structure of ttha0275 from thermus thermophilus (hb8) in2 complex with adenosine in space group p212121 Phyre2 PDB 1gz0 chain G Region: 2 - 148 Aligned: 145 Modelled: 138 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1gz0 chain A domain 1 Region: 2 - 148 Aligned: 145 Modelled: 147 Confidence: 100.0% Identity: 19% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1ipa chain A Region: 2 - 148 Aligned: 143 Modelled: 143 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase Phyre2 PDB 2i6d chain A Region: 2 - 148 Aligned: 145 Modelled: 144 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. Phyre2 PDB 3e5y chain B Region: 1 - 153 Aligned: 138 Modelled: 138 Confidence: 100.0% Identity: 49% PDB header:transferase Chain: B: PDB Molecule:trmh family rna methyltransferase; PDBTitle: crystal structure of trmh family rna methyltransferase from2 burkholderia pseudomallei Phyre2 PDB 5kzk chain A Region: 2 - 148 Aligned: 144 Modelled: 141 Confidence: 100.0% Identity: 22% PDB header:rna binding protein Chain: A: PDB Molecule:probable rna methyltransferase, trmh family; PDBTitle: crystal structure of rrna methyltransferase from sinorhizobium2 meliloti Phyre2 PDB 3gyq chain B Region: 2 - 148 Aligned: 144 Modelled: 144 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex Phyre2 PDB 1ipa chain A domain 1 Region: 2 - 148 Aligned: 143 Modelled: 143 Confidence: 100.0% Identity: 33% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1v2x chain A Region: 2 - 148 Aligned: 143 Modelled: 147 Confidence: 100.0% Identity: 29% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1zjr chain A Region: 2 - 152 Aligned: 148 Modelled: 151 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:trna (guanosine-2'-o-)-methyltransferase; PDBTitle: crystal structure of a. aeolicus trmh/spou trna modifying enzyme Phyre2 PDB 3l8u chain A Region: 3 - 152 Aligned: 141 Modelled: 150 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:putative rrna methylase; PDBTitle: crystal structure of smu.1707c, a putative rrna methyltransferase from2 streptococcus mutans ua159 Phyre2 PDB 2ha8 chain A Region: 2 - 151 Aligned: 147 Modelled: 150 Confidence: 100.0% Identity: 18% PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 Phyre2 PDB 3onp chain A Region: 4 - 147 Aligned: 142 Modelled: 137 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:trna/rrna methyltransferase (spou); PDBTitle: crystal structure of trna/rrna methyltransferase spou from rhodobacter2 sphaeroides Phyre2 PDB 3ic6 chain A Region: 2 - 151 Aligned: 148 Modelled: 150 Confidence: 100.0% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative methylase family protein; PDBTitle: crystal structure of putative methylase family protein from neisseria2 gonorrhoeae Phyre2 1 d1mxia_ 2 c4pzkA_ 3 c1gz0H_ 4 c5co4A_ 5 c1x7pB_ 6 c4x3mB_ 7 c1gz0G_ 8 d1gz0a1 9 c1ipaA_ 10 c2i6dA_ 11 c3e5yB_ 12 c5kzkA_ 13 c3gyqB_ 14 d1ipaa1 15 d1v2xa_ 16 c1zjrA_ 17 c3l8uA_ 18 c2ha8A_ 19 c3onpA_ 20 c3ic6A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99