1

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10

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20

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30

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.

.

.

Sequence

M

W

F

A

L

V

N

P

E

M

L

A

A

A

A

T

D

L

G

G

I

R

S

G

I

S

A

A

Y

A

R

P

L

R

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 59%) Alpha helix ( 68%) Beta strand ( 12%)

Rank Aligned region

PDB 5xfs chain A Region: 8 - 30 Aligned: 23 Modelled: 23 Confidence: 95.8% Identity: 48% PDB header:protein transport Chain: A: PDB Molecule:pe family protein pe8; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain A domain 1 Region: 8 - 30 Aligned: 23 Modelled: 23 Confidence: 95.7% Identity: 39% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PE Phyre2 PDB 2g38 chain A Region: 8 - 30 Aligned: 23 Modelled: 23 Confidence: 95.7% Identity: 39% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 4pro chain D Region: 7 - 19 Aligned: 13 Modelled: 13 Confidence: 17.4% Identity: 38% PDB header:serine protease Chain: D: PDB Molecule:alpha-lytic protease; PDBTitle: alpha-lytic protease complexed with pro region Phyre2 PDB 2n3x chain A Region: 6 - 18 Aligned: 13 Modelled: 13 Confidence: 13.9% Identity: 54% PDB header:dna binding protein Chain: A: PDB Molecule:tar dna-binding protein 43; PDBTitle: solution structure of tdp-43 amyloidogenic core region Phyre2 PDB 2n2c chain A Region: 6 - 18 Aligned: 13 Modelled: 13 Confidence: 13.4% Identity: 54% PDB header:dna binding protein Chain: A: PDB Molecule:tar dna-binding protein 43; PDBTitle: nmr structure of tdp-43 prion-like hydrophobic helix in dpc Phyre2 PDB 4mm1 chain E Region: 6 - 28 Aligned: 23 Modelled: 23 Confidence: 8.8% Identity: 57% PDB header:transferase Chain: E: PDB Molecule:geranylgeranylglyceryl phosphate synthase; PDBTitle: gggps from methanothermobacter thermautotrophicus Phyre2 PDB 1c9k chain A Region: 18 - 27 Aligned: 10 Modelled: 10 Confidence: 8.7% Identity: 60% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: RecA protein-like (ATPase-domain) Phyre2 PDB 2vs0 chain B Region: 6 - 31 Aligned: 26 Modelled: 25 Confidence: 8.5% Identity: 19% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 6elu chain J Region: 11 - 30 Aligned: 16 Modelled: 20 Confidence: 6.7% Identity: 75% PDB header:antitoxin Chain: J: PDB Molecule:serum resistance associated; vsg protein; PDBTitle: structure of serum resistance associated protein from t. b.2 rhodesiense Phyre2 PDB 4iog chain D Region: 6 - 31 Aligned: 26 Modelled: 26 Confidence: 5.5% Identity: 19% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 1 c5xfsA_ 2 d2g38a1 3 c2g38A_ 4 c4proD_ 5 c2n3xA_ 6 c2n2cA_ 7 c4mm1E_ 8 d1c9ka_ 9 c2vs0B_ 10 c6eluJ_ 11 c4iogD_