1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	E	T	F	R	T	L	L	A	K	A	A	L	G	N	G	I	S	S	T	A	Y	D	T	A	W	V	A	K	L	G	Q	L	D	D	E	L	S	D	L	A	L	N	W	L	C	E	R	Q	L	P	D	G	S	W	G	A	E	F	P
Secondary structure
SS confidence
Disorder		?										?	?	?	?	?	?																	?	?																	?	?	?	?	?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	C	Y	E	D	R	L	L	S	T	L	A	A	M	I	S	L	T	S	N	K	H	R	R	R	R	A	A	Q	V	E	K	G	L	L	A	L	K	N	L	T	S	G	A	F	E	G	P	Q	L	D	I	K	D	A	T	V	G	F	E
Secondary structure
SS confidence
Disorder		?	?	?		?																?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	I	A	P	T	L	M	A	E	A	A	R	L	G	L	A	I	C	H	E	E	S	I	L	G	E	L	V	G	V	R	E	Q	K	L	R	K	L	G	G	S	K	I	N	K	H	I	T	A	A	F	S	V	E	L	A	G	Q	D	G
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?				?	?				?	?		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	G	M	L	D	V	D	N	L	Q	E	T	N	G	S	V	K	Y	S	P	S	A	S	A	Y	F	A	L	H	V	K	P	G	D	K	R	A	L	A	Y	I	S	S	I	I	Q	A	G	D	G	G	A	P	A	F	Y	Q	A	E	I
Secondary structure
SS confidence
Disorder									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	E	I	V	W	S	L	W	N	L	S	R	T	D	I	D	L	S	D	P	E	I	V	R	T	Y	L	P	Y	L	D	H	V	E	Q	H	W	V	R	G	R	G	V	G	W	T	G	N	S	T	L	E	D	C	D	T	T	S	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	D	V	L	S	K	F	G	R	S	P	D	I	G	A	V	L	Q	F	E	D	A	D	W	F	R	T	Y	F	H	E	V	G	P	S	I	S	T	N	V	H	V	L	G	A	L	K	Q	A	G	Y	D	K	C	H	P	R	V	R	K
Secondary structure
SS confidence
Disorder																																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	L	E	F	I	R	S	S	K	E	P	G	R	F	C	W	R	D	K	W	H	R	S	A	Y	Y	T	T	A	H	L	I	C	A	A	S	N	Y	D	D	A	L	C	S	D	A	I	G	W	I	L	N	T	Q	R	P	D	G	S	W
Secondary structure
SS confidence
Disorder													?																																												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	F	F	D	G	Q	A	T	A	E	E	T	A	Y	C	I	Q	A	L	A	H	W	Q	R	H	S	G	T	S	L	S	A	Q	I	S	R	A	G	G	W	L	S	Q	H	C	E	P	P	Y	A	P	L	W	I	A	K	T	L	Y	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?																					?																				?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.
Sequence		S	A	T	V	V	K	A	A	I	L	S	A	L	R	L	V	D	E	S	N	Q
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 57%) Beta strand ( 0%)

Rank Aligned region

PDB 5bp8 chain A Region: 2 - 496 Aligned: 478 Modelled: 495 Confidence: 100.0% Identity: 27% PDB header:isomerase Chain: A: PDB Molecule:ent-copalyl diphosphate synthase; PDBTitle: ent-copalyl diphosphate synthase from streptomyces platensis Phyre2 PDB 1w6k chain A Region: 2 - 500 Aligned: 490 Modelled: 499 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:lanosterol synthase; PDBTitle: structure of human osc in complex with lanosterol Phyre2 PDB 1o79 chain A Region: 2 - 499 Aligned: 489 Modelled: 498 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:squalene--hopene cyclase; PDBTitle: structures of human oxidosqualene cyclase inhibitors bound to an2 homologous enzyme Phyre2 PDB 3pyb chain B Region: 1 - 384 Aligned: 368 Modelled: 384 Confidence: 100.0% Identity: 24% PDB header:isomerase Chain: B: PDB Molecule:ent-copalyl diphosphate synthase, chloroplastic; PDBTitle: crystal structure of ent-copalyl diphosphate synthase from arabidopsis2 thaliana in complex with 13-aza-13,14-dihydrocopalyl diphosphate Phyre2 PDB 3s9v chain D Region: 1 - 384 Aligned: 369 Modelled: 384 Confidence: 100.0% Identity: 25% PDB header:lyase, isomerase Chain: D: PDB Molecule:abietadiene synthase, chloroplastic; PDBTitle: abietadiene synthase from abies grandis Phyre2 PDB 3p5r chain B Region: 1 - 367 Aligned: 351 Modelled: 367 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: B: PDB Molecule:taxadiene synthase; PDBTitle: crystal structure of taxadiene synthase from pacific yew (taxus2 brevifolia) in complex with mg2+ and 2-fluorogeranylgeranyl3 diphosphate Phyre2 PDB 3sae chain A Region: 1 - 380 Aligned: 365 Modelled: 380 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: A: PDB Molecule:alpha-bisabolene synthase; PDBTitle: structure of a three-domain sesquiterpene synthase: a prospective2 target for advanced biofuels production Phyre2 PDB 1w6k chain A domain 1 Region: 206 - 476 Aligned: 264 Modelled: 271 Confidence: 100.0% Identity: 19% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Terpene synthases Phyre2 PDB 2sqc chain A domain 1 Region: 215 - 501 Aligned: 279 Modelled: 287 Confidence: 100.0% Identity: 20% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Terpene synthases Phyre2 PDB 2sqc chain A domain 2 Region: 238 - 473 Aligned: 218 Modelled: 231 Confidence: 100.0% Identity: 16% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Terpene synthases Phyre2 PDB 1w6k chain A domain 2 Region: 34 - 273 Aligned: 227 Modelled: 240 Confidence: 99.8% Identity: 13% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Terpene synthases Phyre2 PDB 3dss chain B domain 1 Region: 300 - 500 Aligned: 192 Modelled: 201 Confidence: 99.8% Identity: 15% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Protein prenyltransferases Phyre2 PDB 1r76 chain A Region: 264 - 486 Aligned: 186 Modelled: 188 Confidence: 99.7% Identity: 23% Fold: alpha/alpha toroid Superfamily: Family 10 polysaccharide lyase Family: Family 10 polysaccharide lyase Phyre2 PDB 1qqf chain A Region: 215 - 441 Aligned: 218 Modelled: 227 Confidence: 99.6% Identity: 13% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Complement components Phyre2 PDB 1hzf chain A Region: 215 - 441 Aligned: 219 Modelled: 227 Confidence: 99.5% Identity: 10% PDB header:immune system Chain: A: PDB Molecule:complement factor c4a; PDBTitle: c4adg fragment of human complement factor c4a Phyre2 PDB 1hzf chain A Region: 215 - 441 Aligned: 219 Modelled: 227 Confidence: 99.5% Identity: 10% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Complement components Phyre2 PDB 1c3d chain A Region: 261 - 441 Aligned: 173 Modelled: 181 Confidence: 99.5% Identity: 14% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Complement components Phyre2 PDB 3e37 chain B Region: 300 - 469 Aligned: 164 Modelled: 170 Confidence: 99.4% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:protein farnesyltransferase subunit beta; PDBTitle: protein farnesyltransferase complexed with bisubstrate2 ethylenediamine scaffold inhibitor 5 Phyre2 PDB 2h6f chain B domain 1 Region: 300 - 465 Aligned: 160 Modelled: 166 Confidence: 99.4% Identity: 18% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Protein prenyltransferases Phyre2 PDB 1n4q chain B Region: 215 - 466 Aligned: 228 Modelled: 229 Confidence: 99.4% Identity: 13% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Protein prenyltransferases Phyre2 1 c5bp8A_ 2 c1w6kA_ 3 c1o79A_ 4 c3pybB_ 5 c3s9vD_ 6 c3p5rB_ 7 c3saeA_ 8 d1w6ka1 9 d2sqca1 10 d2sqca2 11 d1w6ka2 12 d3dssb1 13 d1r76a_ 14 d1qqfa_ 15 c1hzfA_ 16 d1hzfa_ 17 d1c3da_ 18 c3e37B_ 19 d2h6fb1 20 d1n4qb_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119