1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	R	N	A	Q	R	A	V	R	R	A	S	G	R	R	K	A	W	L	R	Q	A	I	N	H	L	E	K	L	I	G	R	T	E	R	V	V	D	Q	A	R	S	R	L	A	G	V	M	P	D	S	S	S	R	L	V	S	L	H
Secondary structure
SS confidence
Disorder		?	?																																										?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	A	D	A	R	P	I	R	K	G	R	L	G	K	P	V	E	F	G	Y	K	A	Q	V	V	D	N	A	D	G	V	I	L	D	H	S	V	E	L	G	N	P	A	D	A	P	Q	L	A	P	A	I	E	R	I	S	R	R	T	G
Secondary structure
SS confidence
Disorder													?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	P	P	R	A	V	T	A	D	R	G	C	G	D	A	S	V	E	D	D	L	H	Q	L	G	V	R	N	V	A	I	P	R	K	S	K	P	S	A	T	R	R	A	F	E	H	R	R	A	F	R	D	K	I	K	W	R	T	G	S
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.
Sequence		E	G	R	I	N	H	L	K	R	S	Y	G	W	N	R	T	E	L	T	G	I	T	G	A	R	T	W	C	G	H	G	V	F	A	H	N	L	V	K	I	S	T	L	A	A
Secondary structure
SS confidence
Disorder																																													?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 56%) Beta strand ( 14%) TM helix ( 8%) (View membrane topology prediction)

Rank Aligned region

PDB 1mus chain A Region: 56 - 214 Aligned: 159 Modelled: 159 Confidence: 98.0% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1b7e chain A Region: 109 - 224 Aligned: 115 Modelled: 116 Confidence: 97.2% Identity: 20% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Transposase inhibitor (Tn5 transposase) Phyre2 PDB 1asu chain A Region: 80 - 216 Aligned: 115 Modelled: 119 Confidence: 91.0% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1cxq chain A Region: 80 - 216 Aligned: 110 Modelled: 115 Confidence: 78.3% Identity: 19% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 5cz1 chain B Region: 80 - 216 Aligned: 112 Modelled: 119 Confidence: 64.5% Identity: 12% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 3nf9 chain A Region: 80 - 216 Aligned: 111 Modelled: 119 Confidence: 62.3% Identity: 18% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 1c0m chain A Region: 80 - 189 Aligned: 88 Modelled: 92 Confidence: 50.3% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:protein (integrase); PDBTitle: crystal structure of rsv two-domain integrase Phyre2 PDB 4mq3 chain A Region: 80 - 216 Aligned: 113 Modelled: 119 Confidence: 49.2% Identity: 14% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 5j9w chain B Region: 3 - 60 Aligned: 57 Modelled: 57 Confidence: 43.5% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:chromatin modification-related protein eaf6; PDBTitle: crystal structure of the nua4 core complex Phyre2 PDB 1h5y chain A Region: 95 - 151 Aligned: 57 Modelled: 57 Confidence: 31.3% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 3kks chain B Region: 80 - 216 Aligned: 113 Modelled: 119 Confidence: 29.4% Identity: 13% PDB header:dna binding protein Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of catalytic core domain of biv integrase in crystal2 form ii Phyre2 PDB 3j6v chain I Region: 58 - 119 Aligned: 59 Modelled: 59 Confidence: 28.1% Identity: 20% PDB header:ribosome Chain: I: PDB Molecule:28s ribosomal protein s9, mitochondrial; PDBTitle: cryo-em structure of the small subunit of the mammalian mitochondrial2 ribosome Phyre2 PDB 1exq chain A Region: 80 - 216 Aligned: 104 Modelled: 112 Confidence: 25.6% Identity: 18% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3jca chain E Region: 82 - 216 Aligned: 113 Modelled: 117 Confidence: 23.5% Identity: 12% PDB header:viral protein Chain: E: PDB Molecule:integrase; PDBTitle: core model of the mouse mammary tumor virus intasome Phyre2 PDB 3tsm chain B Region: 101 - 151 Aligned: 51 Modelled: 51 Confidence: 21.3% Identity: 16% PDB header:lyase Chain: B: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of indole-3-glycerol phosphate synthase from2 brucella melitensis Phyre2 PDB 5u1c chain D Region: 80 - 217 Aligned: 96 Modelled: 104 Confidence: 19.5% Identity: 24% PDB header:viral protein Chain: D: PDB Molecule:hiv-1 integrase, sso7d chimera; PDBTitle: structure of tetrameric hiv-1 strand transfer complex intasome Phyre2 PDB 3qja chain A Region: 101 - 151 Aligned: 51 Modelled: 51 Confidence: 18.4% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form Phyre2 PDB 3hpg chain C Region: 82 - 216 Aligned: 110 Modelled: 117 Confidence: 15.4% Identity: 12% PDB header:transferase Chain: C: PDB Molecule:integrase; PDBTitle: visna virus integrase (residues 1-219) in complex with ledgf2 ibd: examples of open integrase dimer-dimer interfaces Phyre2 PDB 5ejk chain G Region: 78 - 148 Aligned: 67 Modelled: 71 Confidence: 15.4% Identity: 18% PDB header:transferase/dna Chain: G: PDB Molecule:gag-pro-pol polyprotein; PDBTitle: crystal structure of the rous sarcoma virus intasome Phyre2 PDB 3f9k chain V Region: 82 - 216 Aligned: 112 Modelled: 117 Confidence: 15.3% Identity: 13% PDB header:viral protein, recombination Chain: V: PDB Molecule:integrase; PDBTitle: two domain fragment of hiv-2 integrase in complex with ledgf ibd Phyre2 1 d1musa_ 2 d1b7ea_ 3 d1asua_ 4 d1cxqa_ 5 c5cz1B_ 6 c3nf9A_ 7 c1c0mA_ 8 c4mq3A_ 9 c5j9wB_ 10 d1h5ya_ 11 c3kksB_ 12 c3j6vI_ 13 d1exqa_ 14 c3jcaE_ 15 c3tsmB_ 16 c5u1cD_ 17 c3qjaA_ 18 c3hpgC_ 19 c5ejkG_ 20 c3f9kV_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50