1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	I	D	P	N	S	I	G	A	V	T	E	P	M	L	F	E	W	T	D	R	D	T	L	L	Y	A	I	G	V	G	A	G	T	G	D	L	A	F	T	T	E	N	S	H	G	I	D	Q	Q	V	L	P	T	Y	A	V	I	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		C	P	A	F	G	A	A	A	K	V	G	T	F	N	P	A	A	L	L	H	G	S	Q	G	I	R	L	H	A	P	L	P	A	A	G	K	L	S	V	V	T	E	V	A	D	I	Q	D	K	G	E	G	K	N	A	I	V	V	L	R
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	R	G	C	D	P	E	S	G	S	L	V	A	E	T	L	T	T	L	V	L	R	G	Q	G	G	F	G	G	A	R	G	E	R	P	A	A	P	E	F	P	D	R	H	P	D	A	R	I	D	M	P	T	R	E	D	Q	A	L	I
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	R	L	S	G	D	R	N	P	L	H	S	D	P	W	F	A	T	Q	L	A	G	F	P	K	P	I	L	H	G	L	C	T	Y	G	V	A	G	R	A	L	V	A	E	L	G	G	G	V	A	A	N	I	T	S	I	A	A	R	F
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290
Sequence		T	K	P	V	F	P	G	E	T	L	S	T	V	I	W	R	T	E	P	G	R	A	V	F	R	T	E	V	A	G	S	D	G	A	E	A	R	V	V	L	D	D	G	A	V	E	Y	V	A	G
Secondary structure
SS confidence
Disorder																																																		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 21%) Beta strand ( 38%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 3khp chain B Region: 1 - 289 Aligned: 285 Modelled: 289 Confidence: 100.0% Identity: 99% PDB header:oxidoreductase Chain: B: PDB Molecule:maoc family protein; PDBTitle: crystal structure of a possible dehydrogenase from mycobacterium2 tuberculosis at 2.3a resolution Phyre2 PDB 3oml chain A Region: 13 - 288 Aligned: 253 Modelled: 276 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:peroxisomal multifunctional enzyme type 2, cg3415; PDBTitle: structure of full-length peroxisomal multifunctional enzyme type 22 from drosophila melanogaster Phyre2 PDB 3kh8 chain B Region: 3 - 287 Aligned: 272 Modelled: 285 Confidence: 100.0% Identity: 36% PDB header:lyase Chain: B: PDB Molecule:maoc-like dehydratase; PDBTitle: crystal structure of maoc-like dehydratase from phytophthora capsici Phyre2 PDB 1pn2 chain D Region: 16 - 287 Aligned: 258 Modelled: 272 Confidence: 100.0% Identity: 39% PDB header:lyase Chain: D: PDB Molecule:peroxisomal hydratase-dehydrogenase-epimerase; PDBTitle: crystal structure analysis of the selenomethionine labelled2 2-enoyl-coa hydratase 2 domain of candida tropicalis3 multifunctional enzyme type 2 Phyre2 PDB 1s9c chain K Region: 8 - 287 Aligned: 252 Modelled: 269 Confidence: 100.0% Identity: 40% PDB header:lyase Chain: K: PDB Molecule:peroxisomal multifunctional enzyme type 2; PDBTitle: crystal structure analysis of the 2-enoyl-coa hydratase 22 domain of human peroxisomal multifunctional enzyme type 2 Phyre2 PDB 2cdh chain T Region: 7 - 287 Aligned: 244 Modelled: 270 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: T: PDB Molecule:dehydratase; PDBTitle: architecture of the thermomyces lanuginosus fungal fatty2 acid synthase at 5 angstrom resolution. Phyre2 PDB 4v12 chain A Region: 5 - 288 Aligned: 273 Modelled: 284 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc like domain protein; PDBTitle: crystal structure of the msmeg_6754 dehydratase from mycobacterium2 smegmatis Phyre2 PDB 4e3e chain A Region: 8 - 277 Aligned: 263 Modelled: 270 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc domain protein dehydratase; PDBTitle: crystal structure of putative maoc domain protein dehydratase from2 chloroflexus aurantiacus j-10-fl Phyre2 PDB 2vkz chain H Region: 8 - 289 Aligned: 271 Modelled: 282 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: H: PDB Molecule:fatty acid synthase subunit beta; PDBTitle: structure of the cerulenin-inhibited fungal fatty acid synthase type i2 multienzyme complex Phyre2 PDB 1pn2 chain A domain 1 Region: 14 - 157 Aligned: 140 Modelled: 144 Confidence: 100.0% Identity: 31% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 2uva chain I Region: 17 - 289 Aligned: 262 Modelled: 273 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: I: PDB Molecule:fatty acid synthase beta subunits; PDBTitle: crystal structure of fatty acid synthase from thermomyces2 lanuginosus at 3.1 angstrom resolution. this file contains3 the beta subunits of the fatty acid synthase. the entire4 crystal structure consists of one heterododecameric fatty5 acid synthase and is described in remark 400 Phyre2 PDB 4b3y chain B Region: 11 - 290 Aligned: 273 Modelled: 254 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase; PDBTitle: cryo-em structure of the mycobacterial fatty acid synthase Phyre2 PDB 1s9c chain A domain 1 Region: 157 - 287 Aligned: 125 Modelled: 131 Confidence: 100.0% Identity: 42% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 1pn2 chain A domain 2 Region: 156 - 287 Aligned: 122 Modelled: 132 Confidence: 100.0% Identity: 49% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 1s9c chain A domain 2 Region: 7 - 142 Aligned: 114 Modelled: 136 Confidence: 100.0% Identity: 36% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 2bi0 chain A Region: 8 - 281 Aligned: 265 Modelled: 274 Confidence: 100.0% Identity: 18% PDB header:hypothetical protein Chain: A: PDB Molecule:hypothetical protein rv0216; PDBTitle: rv0216, a conserved hypothetical protein from mycobacterium2 tuberculosis that is essential for bacterial survival3 during infection, has a double hotdogfold Phyre2 PDB 4rlt chain A Region: 1 - 152 Aligned: 148 Modelled: 152 Confidence: 99.9% Identity: 20% PDB header:lyase/lyase inhibitor Chain: A: PDB Molecule:(3r)-hydroxyacyl-acp dehydratase subunit hada; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium tuberculosis complexed with fisetin Phyre2 PDB 4w7b chain D Region: 159 - 288 Aligned: 123 Modelled: 130 Confidence: 99.8% Identity: 20% PDB header:lyase Chain: D: PDB Molecule:hydratase chsh2; PDBTitle: crystal structure of the chsh1:chsh2: complex from mycobacterium2 tuberculosis Phyre2 PDB 2b3n chain A domain 1 Region: 173 - 287 Aligned: 108 Modelled: 115 Confidence: 99.8% Identity: 26% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 5cpg chain A Region: 173 - 287 Aligned: 109 Modelled: 115 Confidence: 99.8% Identity: 31% PDB header:lyase Chain: A: PDB Molecule:(r)-specific enoyl-coa hydratase; PDBTitle: r-hydratase phaj1 from pseudomonas aeruginosa in the unliganded form Phyre2 1 c3khpB_ 2 c3omlA_ 3 c3kh8B_ 4 c1pn2D_ 5 c1s9cK_ 6 c2cdhT_ 7 c4v12A_ 8 c4e3eA_ 9 c2vkzH_ 10 d1pn2a1 11 c2uvaI_ 12 c4b3yB_ 13 d1s9ca1 14 d1pn2a2 15 d1s9ca2 16 c2bi0A_ 17 c4rltA_ 18 c4w7bD_ 19 d2b3na1 20 c5cpgA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171