1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	K	R	T	P	V	R	K	A	C	T	V	L	A	V	L	A	A	T	L	L	L	G	A	C	G	G	P	T	Q	P	R	S	I	T	L	T	F	I	R	N	A	Q	S	Q	A	N	A	D	G	I	I	D	T	D	M	P	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	S	A	D	G	K	A	E	A	Q	Q	V	A	H	Q	V	S	R	R	D	V	D	S	I	Y	S	S	P	M	A	A	D	Q	Q	T	A	G	P	L	A	G	E	L	G	K	Q	V	E	I	L	P	G	L	Q	A	I	N	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	F	N	G	K	P	E	S	M	A	N	S	T	Y	M	L	A	P	A	D	W	L	A	G	D	V	H	N	T	I	P	G	S	I	S	G	T	E	F	N	S	Q	F	S	A	A	V	R	K	I	Y	D	S	G	H	N	T	P	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.
Sequence		F	S	Q	G	V	A	I	M	I	W	T	L	M	N	A	R	N	S	R	D	S	L	L	T	T	H	P	L	P	N	I	G	R	V	V	I	T	G	N	P	V	T	G	W	R	L	V	E	W	D	G	I	R	N	F	T
Secondary structure
SS confidence
Disorder																																																					?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 41%) Beta strand ( 14%)

Rank Aligned region

PDB 1e58 chain A Region: 34 - 230 Aligned: 194 Modelled: 197 Confidence: 100.0% Identity: 16% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 4ij5 chain B Region: 35 - 231 Aligned: 194 Modelled: 196 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:phosphoserine phosphatase 1; PDBTitle: crystal structure of a novel-type phosphoserine phosphatase from2 hydrogenobacter thermophilus tk-6 Phyre2 PDB 4pz9 chain B Region: 34 - 231 Aligned: 193 Modelled: 198 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:glucosyl-3-phosphoglycerate phosphatase; PDBTitle: the native structure of mycobacterial glucosyl-3-phosphoglycerate2 phosphatase rv2419c Phyre2 PDB 1h2e chain A Region: 34 - 232 Aligned: 197 Modelled: 199 Confidence: 100.0% Identity: 15% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 3f3k chain A Region: 32 - 229 Aligned: 196 Modelled: 197 Confidence: 100.0% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ykr043c; PDBTitle: the structure of uncharacterized protein ykr043c from saccharomyces2 cerevisiae. Phyre2 PDB 4emb chain D Region: 36 - 230 Aligned: 192 Modelled: 195 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: D: PDB Molecule:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; PDBTitle: crystal structure of a phosphoglycerate mutase gpma from borrelia2 burgdorferi b31 Phyre2 PDB 2i1v chain B Region: 32 - 230 Aligned: 188 Modelled: 199 Confidence: 100.0% Identity: 19% PDB header:transferase, hydrolase Chain: B: PDB Molecule:6-phosphofructo-2-kinase/fructose-2,6- PDBTitle: crystal structure of pfkfb3 in complex with adp and2 fructose-2,6-bisphosphate Phyre2 PDB 3ll4 chain B Region: 32 - 234 Aligned: 201 Modelled: 203 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein ykr043c; PDBTitle: structure of the h13a mutant of ykr043c in complex with fructose-1,6-2 bisphosphate Phyre2 PDB 1k6m chain A Region: 32 - 230 Aligned: 188 Modelled: 199 Confidence: 100.0% Identity: 19% PDB header:transferase, hydrolase Chain: A: PDB Molecule:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2- PDBTitle: crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2,2 6-bisphosphatase Phyre2 PDB 6e4b chain C Region: 33 - 231 Aligned: 196 Modelled: 199 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: C: PDB Molecule:adenosylcobalamin/alpha-ribazole phosphatase; PDBTitle: the crystal structure of a putative alpha-ribazole-5'-p phosphatase2 from escherichia coli str. k-12 substr. mg1655 Phyre2 PDB 5vve chain A Region: 34 - 230 Aligned: 194 Modelled: 196 Confidence: 100.0% Identity: 14% PDB header:isomerase Chain: A: PDB Molecule:phosphoglycerate mutase; PDBTitle: crystal structure of phosphoglycerate mutase from naegleria fowleri Phyre2 PDB 1yjx chain D Region: 36 - 221 Aligned: 184 Modelled: 186 Confidence: 100.0% Identity: 14% PDB header:isomerase, hydrolase Chain: D: PDB Molecule:phosphoglycerate mutase 1; PDBTitle: crystal structure of human b type phosphoglycerate mutase Phyre2 PDB 1xq9 chain A Region: 36 - 230 Aligned: 192 Modelled: 194 Confidence: 100.0% Identity: 16% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 3dcy chain A Region: 31 - 235 Aligned: 200 Modelled: 205 Confidence: 100.0% Identity: 18% PDB header:apoptosis regulator Chain: A: PDB Molecule:regulator protein; PDBTitle: crystal structure a tp53-induced glycolysis and apoptosis regulator2 protein from homo sapiens. Phyre2 PDB 1fzt chain A Region: 31 - 231 Aligned: 199 Modelled: 201 Confidence: 100.0% Identity: 13% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 3e9e chain B Region: 34 - 235 Aligned: 198 Modelled: 202 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:zgc:56074; PDBTitle: structure of full-length h11a mutant form of tigar from danio rerio Phyre2 PDB 1rii chain A Region: 32 - 232 Aligned: 197 Modelled: 199 Confidence: 100.0% Identity: 17% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 3r7a chain A Region: 28 - 232 Aligned: 198 Modelled: 204 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate mutase, putative; PDBTitle: crystal structure of phosphoglycerate mutase from bacillus anthracis2 str. sterne Phyre2 PDB 2hhj chain A domain 1 Region: 35 - 221 Aligned: 184 Modelled: 187 Confidence: 100.0% Identity: 17% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1bif chain A Region: 32 - 229 Aligned: 187 Modelled: 198 Confidence: 100.0% Identity: 18% PDB header:bifunctional enzyme Chain: A: PDB Molecule:6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; PDBTitle: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bifunctional2 enzyme complexed with atp-g-s and phosphate Phyre2 1 d1e58a_ 2 c4ij5B_ 3 c4pz9B_ 4 d1h2ea_ 5 c3f3kA_ 6 c4embD_ 7 c2i1vB_ 8 c3ll4B_ 9 c1k6mA_ 10 c6e4bC_ 11 c5vveA_ 12 c1yjxD_ 13 d1xq9a_ 14 c3dcyA_ 15 d1fzta_ 16 c3e9eB_ 17 d1riia_ 18 c3r7aA_ 19 d2hhja1 20 c1bifA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99