1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	M	A	S	A	R	V	L	A	I	W	C	M	D	W	P	A	V	A	A	A	A	A	A	G	L	S	A	T	A	P	V	A	V	T	L	A	N	R	V	I	A	C	S	A	T	A	R	A	A	G	V	R	R	G	L	R	R	R	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?																		?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	A	R	C	P	Q	L	F	I	A	T	A	D	A	D	R	D	A	R	L	F	E	G	V	I	A	A	V	D	D	L	V	P	R	A	E	L	L	R	P	G	L	L	V	L	P	V	R	G	P	A	R	F	F	G	S	E	Q	M
Secondary structure
SS confidence
Disorder																																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	E	R	L	I	D	A	V	A	A	A	G	A	E	C	Q	V	G	I	A	D	R	L	S	T	A	V	F	A	A	R	A	G	R	I	V	E	P	G	G	D	A	R	F	L	S	L	L	S	I	R	Q	L	A	T	E	P	S	L
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	G	P	G	R	D	D	L	T	D	L	L	W	R	M	G	I	R	T	I	G	Q	F	A	A	L	S	R	T	D	V	A	S	R	F	G	A	D	A	V	A	A	H	R	F	A	R	G	E	P	E	R	A	P	C	G	R	E	P	P
Secondary structure
SS confidence
Disorder		?	?	?	?																																																				?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	D	L	A	A	E	L	A	C	D	P	P	I	D	R	V	D	A	A	A	F	A	G	R	S	L	A	A	E	L	H	R	A	L	M	A	A	G	V	G	C	T	R	L	A	I	H	A	V	T	A	N	G	E	E	R	S	R	V	W
Secondary structure
SS confidence
Disorder		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	C	A	E	P	L	T	E	D	A	T	A	D	R	V	R	W	Q	L	D	G	W	L	N	N	R	N	A	R	D	R	P	T	A	A	V	T	L	L	R	L	Q	A	V	E	T	V	S	A	S	E	G	L	Q	L	P	L	W	G	G
Secondary structure
SS confidence
Disorder																														?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	G	E	Q	D	R	L	R	A	R	R	A	L	V	R	V	Q	G	L	L	G	P	E	A	V	R	V	P	V	L	S	G	G	H	G	P	A	E	R	I	T	L	T	V	L	G	L	V	A	P	E	P	V	P	Q	A	D	P	G	Q
Secondary structure
SS confidence
Disorder		?	?	?																												?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	W	P	G	R	L	P	D	P	S	P	A	V	L	F	D	D	P	V	D	L	L	D	A	Q	G	N	P	I	R	V	T	S	R	G	M	F	S	A	D	P	A	R	L	R	V	R	G	R	D	D	R	L	R	W	W	A	G	P	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?		?	?		?							?	?	?	?	?	?	?					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.
Sequence		P	D	D	E	R	W	W	D	P	D	R	A	S	G	R	T	A	R	A	Q	V	L	L	D	G	D	P	G	T	A	L	L	L	C	Y	R	Q	R	R	W	Y	L	E	G	S	Y	E
Secondary structure
SS confidence
Disorder											?	?	?																																			?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 33%) Beta strand ( 23%)

Rank Aligned region

PDB 4ir1 chain A Region: 4 - 348 Aligned: 335 Modelled: 345 Confidence: 100.0% Identity: 18% PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase iv; PDBTitle: polymerase-dna complex Phyre2 PDB 1s97 chain D Region: 7 - 347 Aligned: 329 Modelled: 341 Confidence: 100.0% Identity: 14% PDB header:transferase/dna Chain: D: PDB Molecule:dna polymerase iv; PDBTitle: dpo4 with gt mismatch Phyre2 PDB 1t94 chain B Region: 2 - 346 Aligned: 335 Modelled: 342 Confidence: 100.0% Identity: 15% PDB header:replication Chain: B: PDB Molecule:polymerase (dna directed) kappa; PDBTitle: crystal structure of the catalytic core of human dna polymerase kappa Phyre2 PDB 3gqc chain B Region: 2 - 350 Aligned: 340 Modelled: 349 Confidence: 100.0% Identity: 16% PDB header:transferase/dna Chain: B: PDB Molecule:dna repair protein rev1; PDBTitle: structure of human rev1-dna-dntp ternary complex Phyre2 PDB 2oh2 chain B Region: 7 - 346 Aligned: 334 Modelled: 338 Confidence: 100.0% Identity: 15% PDB header:transferase/dna Chain: B: PDB Molecule:dna polymerase kappa; PDBTitle: ternary complex of human dna polymerase Phyre2 PDB 2fll chain A Region: 7 - 346 Aligned: 326 Modelled: 340 Confidence: 100.0% Identity: 18% PDB header:replication/dna Chain: A: PDB Molecule:dna polymerase iota; PDBTitle: ternary complex of human dna polymerase iota with dna and dttp Phyre2 PDB 1t3n chain B Region: 7 - 346 Aligned: 336 Modelled: 340 Confidence: 100.0% Identity: 16% PDB header:replication/dna Chain: B: PDB Molecule:polymerase (dna directed) iota; PDBTitle: structure of the catalytic core of dna polymerase iota in complex with2 dna and dttp Phyre2 PDB 3mr2 chain A Region: 7 - 349 Aligned: 333 Modelled: 343 Confidence: 100.0% Identity: 19% PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: human dna polymerase eta in complex with normal dna and incoming2 nucleotide (nrm) Phyre2 PDB 1k1q chain A Region: 7 - 348 Aligned: 326 Modelled: 339 Confidence: 100.0% Identity: 14% PDB header:transcription Chain: A: PDB Molecule:dbh protein; PDBTitle: crystal structure of a dinb family error prone dna2 polymerase from sulfolobus solfataricus Phyre2 PDB 1jih chain A Region: 7 - 346 Aligned: 336 Modelled: 340 Confidence: 100.0% Identity: 16% PDB header:translation Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: yeast dna polymerase eta Phyre2 PDB 2r8k chain B Region: 7 - 346 Aligned: 336 Modelled: 340 Confidence: 100.0% Identity: 16% PDB header:replication, transferase/dna Chain: B: PDB Molecule:dna polymerase eta; PDBTitle: structure of the eukaryotic dna polymerase eta in complex with 1,2-2 d(gpg)-cisplatin containing dna Phyre2 PDB 2aq4 chain A Region: 7 - 348 Aligned: 331 Modelled: 342 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:dna repair protein rev1; PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp. Phyre2 PDB 1jx4 chain A domain 2 Region: 7 - 237 Aligned: 228 Modelled: 231 Confidence: 100.0% Identity: 16% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1zet chain A domain 2 Region: 4 - 240 Aligned: 235 Modelled: 237 Confidence: 100.0% Identity: 17% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1k1s chain A domain 2 Region: 5 - 235 Aligned: 228 Modelled: 231 Confidence: 100.0% Identity: 14% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 4dez chain A Region: 4 - 236 Aligned: 229 Modelled: 233 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:dna polymerase iv 1; PDBTitle: structure of msdpo4 Phyre2 PDB 1t94 chain A domain 2 Region: 7 - 234 Aligned: 225 Modelled: 226 Confidence: 100.0% Identity: 17% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1jih chain A domain 2 Region: 7 - 237 Aligned: 224 Modelled: 231 Confidence: 100.0% Identity: 23% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1im4 chain A Region: 7 - 202 Aligned: 193 Modelled: 196 Confidence: 100.0% Identity: 16% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1unn chain C Region: 241 - 357 Aligned: 107 Modelled: 117 Confidence: 99.2% Identity: 17% Fold: Lesion bypass DNA polymerase (Y-family), little finger domain Superfamily: Lesion bypass DNA polymerase (Y-family), little finger domain Family: Lesion bypass DNA polymerase (Y-family), little finger domain Phyre2 1 c4ir1A_ 2 c1s97D_ 3 c1t94B_ 4 c3gqcB_ 5 c2oh2B_ 6 c2fllA_ 7 c1t3nB_ 8 c3mr2A_ 9 c1k1qA_ 10 c1jihA_ 11 c2r8kB_ 12 c2aq4A_ 13 d1jx4a2 14 d1zeta2 15 d1k1sa2 16 c4dezA_ 17 d1t94a2 18 d1jiha2 19 d1im4a_ 20 d1unnc_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99