1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Q	S	R	K	T	T	S	V	L	A	A	A	L	L	F	C	G	L	L	G	P	G	T	A	P	P	A	T	G	G	G	P	A	C	R	P	A	E	L	F	A	T	D	N	T	T	D	G	F	E	L	P	A	V	A	T	I	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?											?	?			?			?	?	?	?	?	?	?	?	?	?	?												?				?						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	G	T	V	V	T	G	S	T	L	V	D	G	V	F	W	S	N	E	R	Q	Q	I	G	Y	E	R	S	R	E	F	H	L	C	V	V	D	A	P	T	L	H	N	A	A	E	A	L	H	R	Q	F	N	Q	E	A	V	L	T	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	Y	L	P	Q	N	A	P	E	A	D	A	I	L	I	T	V	P	D	I	G	I	A	R	F	R	D	A	F	A	S	D	L	A	A	H	H	R	L	R	G	G	S	V	T	T	A	D	H	T	L	I	L	V	A	G	N	G	D	L
Secondary structure
SS confidence
Disorder						?																																	?	?	?	?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.
Sequence		D	V	A	R	R	L	V	E	E	A	G	G	D	W	N	A	T	T	I	A	H	G	R	R	E	F	V	N
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 46%) Beta strand ( 18%)

Rank Aligned region

PDB 3aqo chain D Region: 82 - 151 Aligned: 63 Modelled: 70 Confidence: 32.9% Identity: 17% PDB header:membrane protein Chain: D: PDB Molecule:probable secdf protein-export membrane protein; PDBTitle: structure and function of a membrane component secdf that enhances2 protein export Phyre2 PDB 2f1d chain A domain 2 Region: 92 - 114 Aligned: 23 Modelled: 23 Confidence: 21.4% Identity: 22% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 4i0w chain A Region: 154 - 202 Aligned: 49 Modelled: 49 Confidence: 20.0% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:protease cspb; PDBTitle: structure of the clostridium perfringens cspb protease Phyre2 PDB 2ae8 chain A domain 2 Region: 92 - 114 Aligned: 23 Modelled: 23 Confidence: 15.6% Identity: 22% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 1rhy chain A domain 2 Region: 92 - 113 Aligned: 22 Modelled: 22 Confidence: 15.2% Identity: 18% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Imidazole glycerol phosphate dehydratase Phyre2 PDB 3izc chain S Region: 136 - 184 Aligned: 44 Modelled: 49 Confidence: 14.6% Identity: 18% PDB header:ribosome Chain: S: PDB Molecule:60s ribosomal protein rpl20 (l18ae); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome Phyre2 PDB 2nef chain A Region: 71 - 83 Aligned: 13 Modelled: 13 Confidence: 14.6% Identity: 38% Fold: Regulatory factor Nef Superfamily: Regulatory factor Nef Family: Regulatory factor Nef Phyre2 PDB 1efn chain B Region: 71 - 83 Aligned: 13 Modelled: 13 Confidence: 14.0% Identity: 38% Fold: Regulatory factor Nef Superfamily: Regulatory factor Nef Family: Regulatory factor Nef Phyre2 PDB 2xi1 chain A Region: 71 - 83 Aligned: 13 Modelled: 13 Confidence: 12.6% Identity: 23% PDB header:viral protein Chain: A: PDB Molecule:nef; PDBTitle: crystal structure of the hiv-1 nef sequenced from a patient's sample Phyre2 PDB 2na8 chain A Region: 7 - 21 Aligned: 15 Modelled: 15 Confidence: 12.3% Identity: 47% PDB header:membrane protein Chain: A: PDB Molecule:cytokine receptor common subunit beta; PDBTitle: transmembrane structure of the cytokine receptor common subunit beta Phyre2 PDB 2na9 chain A Region: 7 - 21 Aligned: 15 Modelled: 15 Confidence: 12.2% Identity: 47% PDB header:signaling protein Chain: A: PDB Molecule:cytokine receptor common subunit beta; PDBTitle: transmembrane structure of the p441a mutant of the cytokine receptor2 common subunit beta Phyre2 PDB 4fz1 chain D Region: 85 - 99 Aligned: 15 Modelled: 15 Confidence: 12.1% Identity: 40% PDB header:transport protein Chain: D: PDB Molecule:pi-theraphotoxin-pc1a; PDBTitle: crystal structure of acid-sensing ion channel in complex with2 psalmotoxin 1 at high ph Phyre2 PDB 2f1d chain P Region: 92 - 114 Aligned: 23 Modelled: 23 Confidence: 11.8% Identity: 22% PDB header:lyase Chain: P: PDB Molecule:imidazoleglycerol-phosphate dehydratase 1; PDBTitle: x-ray structure of imidazoleglycerol-phosphate dehydratase Phyre2 PDB 1lmm chain A Region: 85 - 99 Aligned: 15 Modelled: 15 Confidence: 11.4% Identity: 40% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 3ik5 chain A Region: 71 - 83 Aligned: 13 Modelled: 13 Confidence: 11.4% Identity: 31% PDB header:viral protein/signaling protein Chain: A: PDB Molecule:protein nef; PDBTitle: sivmac239 nef in complex with tcr zeta itam 1 polypeptide (a63-r80) Phyre2 PDB 3rbb chain A Region: 71 - 83 Aligned: 13 Modelled: 13 Confidence: 10.9% Identity: 46% PDB header:viral protein, protein binding Chain: A: PDB Molecule:protein nef; PDBTitle: hiv-1 nef protein in complex with engineered hck sh3 domain Phyre2 PDB 4a19 chain X Region: 136 - 187 Aligned: 47 Modelled: 52 Confidence: 10.7% Identity: 19% PDB header:ribosome Chain: X: PDB Molecule:rpl18a; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 26s rrna and3 proteins of molecule 2. Phyre2 PDB 1k1s chain A domain 1 Region: 84 - 112 Aligned: 28 Modelled: 29 Confidence: 9.4% Identity: 18% Fold: Lesion bypass DNA polymerase (Y-family), little finger domain Superfamily: Lesion bypass DNA polymerase (Y-family), little finger domain Family: Lesion bypass DNA polymerase (Y-family), little finger domain Phyre2 PDB 2ae8 chain C Region: 92 - 114 Aligned: 23 Modelled: 23 Confidence: 9.0% Identity: 22% PDB header:lyase Chain: C: PDB Molecule:imidazoleglycerol-phosphate dehydratase; PDBTitle: crystal structure of imidazoleglycerol-phosphate dehydratase from2 staphylococcus aureus subsp. aureus n315 Phyre2 PDB 3kdq chain B Region: 85 - 114 Aligned: 30 Modelled: 30 Confidence: 8.7% Identity: 23% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: crystal structure of a functionally unknown conserved2 protein from corynebacterium diphtheriae. Phyre2 1 c3aqoD_ 2 d2f1da2 3 c4i0wA_ 4 d2ae8a2 5 d1rhya2 6 c3izcS_ 7 d2nefa_ 8 d1efnb_ 9 c2xi1A_ 10 c2na8A_ 11 c2na9A_ 12 c4fz1D_ 13 c2f1dP_ 14 d1lmma_ 15 c3ik5A_ 16 c3rbbA_ 17 c4a19X_ 18 d1k1sa1 19 c2ae8C_ 20 c3kdqB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45