1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	G	T	D	E	K	Y	G	L	P	P	Q	P	D	S	D	R	M	T	R	R	T	L	P	V	L	G	L	A	H	E	L	I	T	P	T	L	R	Q	M	A	D	R	L	D	P	H	M	R	P	V	V	S	Y	H	L	G	W	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	E	R	G	R	P	V	N	N	N	C	G	K	A	I	R	P	A	L	V	F	V	A	A	E	A	A	G	A	D	P	H	S	A	I	P	G	A	V	S	V	E	L	V	H	N	F	S	L	V	H	D	D	L	M	D	R	D	E	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	R	H	R	P	T	V	W	A	L	W	G	D	A	M	A	L	L	A	G	D	A	M	L	S	L	A	H	E	V	L	L	D	C	D	S	P	H	V	G	A	A	L	R	A	I	S	E	A	T	R	E	L	I	R	G	Q	A	A	D
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	A	F	E	S	R	T	D	V	A	L	D	E	C	L	K	M	A	E	G	K	T	A	A	L	M	A	A	S	A	E	V	G	A	L	L	A	G	A	P	R	S	V	R	E	A	L	V	A	Y	G	R	H	I	G	L	A	F	Q	L
Secondary structure
SS confidence
Disorder					?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	D	D	L	L	G	I	W	G	R	P	E	I	T	G	K	P	V	Y	S	D	L	R	S	R	K	K	T	L	P	V	T	W	T	V	A	H	G	G	S	A	G	R	R	L	A	A	W	L	V	D	E	T	G	S	Q	T	A	S	D
Secondary structure
SS confidence
Disorder																																																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.
Sequence		D	E	L	A	A	V	A	E	L	I	E	C	G	G	G	R	R	W	A	S	A	E	A	R	R	H	V	T	Q	G	I	D	M	V	A	R	I	G	I	P	D	R	P	A	A	E	L	Q	D	L	A	H	Y	I	V	D	R	Q	A
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?																?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 75%) Beta strand ( 0%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 3nf2 chain A Region: 23 - 355 Aligned: 333 Modelled: 333 Confidence: 100.0% Identity: 49% PDB header:transferase Chain: A: PDB Molecule:putative polyprenyl synthetase; PDBTitle: crystal structure of polyprenyl synthetase from streptomyces2 coelicolor a3(2) Phyre2 PDB 3mzv chain B Region: 30 - 358 Aligned: 322 Modelled: 329 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:decaprenyl diphosphate synthase; PDBTitle: crystal structure of a decaprenyl diphosphate synthase from2 rhodobacter capsulatus Phyre2 PDB 3oyr chain B Region: 25 - 359 Aligned: 328 Modelled: 335 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:trans-isoprenyl diphosphate synthase; PDBTitle: crystal structure of polyprenyl synthase from caulobacter crescentus2 cb15 complexed with calcium and isoprenyl diphosphate Phyre2 PDB 1wy0 chain A Region: 32 - 358 Aligned: 321 Modelled: 327 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthetase from2 pyrococcus horikoshii ot3 Phyre2 PDB 5h9d chain B Region: 38 - 359 Aligned: 312 Modelled: 322 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:farnesyl pyrophosphate synthetase; PDBTitle: crystal structure of heptaprenyl diphosphate synthase from2 staphylococcus aureus Phyre2 PDB 3aqb chain D Region: 34 - 358 Aligned: 319 Modelled: 325 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: D: PDB Molecule:component b of hexaprenyl diphosphate synthase; PDBTitle: m. luteus b-p 26 heterodimeric hexaprenyl diphosphate synthase in2 complex with magnesium Phyre2 PDB 1wmw chain A Region: 36 - 357 Aligned: 318 Modelled: 322 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl diphosphate synthetase; PDBTitle: crystal structure of geranulgeranyl diphosphate synthase from thermus2 thermophilus Phyre2 PDB 4lob chain A Region: 25 - 357 Aligned: 309 Modelled: 333 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:polyprenyl synthetase; PDBTitle: crystal structure of polyprenyl diphosphate synthase a1s_2732 (target2 efi-509223) from acinetobacter baumannii Phyre2 PDB 3wjn chain A Region: 32 - 355 Aligned: 303 Modelled: 324 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:octaprenyl diphosphate synthase; PDBTitle: crystal structure of octaprenyl pyrophosphate synthase from2 escherichia coli with farnesyl s-thiol-pyrophosphate (fspp) Phyre2 PDB 5jfq chain B Region: 38 - 357 Aligned: 301 Modelled: 320 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: geranylgeranyl pyrophosphate synthetase from archaeon geoglobus2 acetivorans Phyre2 PDB 1fps chain A Region: 34 - 358 Aligned: 317 Modelled: 325 Confidence: 100.0% Identity: 21% Fold: Terpenoid synthases Superfamily: Terpenoid synthases Family: Isoprenyl diphosphate synthases Phyre2 PDB 6b07 chain B Region: 31 - 358 Aligned: 321 Modelled: 328 Confidence: 100.0% Identity: 19% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:farnesyl diphosphate synthase; PDBTitle: crystal structure of cffpps2, a lepidopteran type-ii farnesyl2 diphosphate synthase, complexed with [1-phosphono-2-(1-propylpyridin-3 2-yl)ethyl]phosphonic acid (inhibitor 1d) Phyre2 PDB 3cp6 chain A Region: 34 - 354 Aligned: 308 Modelled: 321 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:farnesyl pyrophosphate synthetase; PDBTitle: crystal structure of human farnesyl diphosphate synthase (t201a2 mutant) complexed with mg and biphosphonate inhibitor Phyre2 PDB 4jzb chain A Region: 34 - 358 Aligned: 318 Modelled: 325 Confidence: 100.0% Identity: 19% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:farnesyl pyrophosphate synthase; PDBTitle: crystal structure of leshmaniasis major farnesyl diphosphate synthase2 in complex with 1-(2-hydroxy-2,2-diphosphonoethyl)-3-3 phenylpyridinium, ipp and ca2+ Phyre2 PDB 4dhd chain A Region: 33 - 358 Aligned: 310 Modelled: 326 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:polyprenyl synthetase; PDBTitle: crystal structure of isoprenoid synthase a3msh1 (target efi-501992)2 from pyrobaculum calidifontis Phyre2 PDB 4kk2 chain B Region: 58 - 358 Aligned: 293 Modelled: 301 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:monoterpene synthase fds-5, chloroplastic - farnesyl PDBTitle: crystal structure of a chimeric fpp/gfpp synthase (target efi-502313c)2 from artemisia spiciformis (1-72:gi751454468,73-346:gi75233326), apo3 structure Phyre2 PDB 2f94 chain F Region: 32 - 354 Aligned: 315 Modelled: 323 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: F: PDB Molecule:farnesyl diphosphate synthase; PDBTitle: crystal structure of human fpps in complex with ibandronate Phyre2 PDB 3oac chain D Region: 34 - 359 Aligned: 283 Modelled: 285 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: D: PDB Molecule:geranyl diphosphate synthase large subunit; PDBTitle: mint deletion mutant of heterotetrameric geranyl pyrophosphate2 synthase in complex with ligands Phyre2 PDB 3n3d chain B Region: 36 - 357 Aligned: 303 Modelled: 322 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate synthase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase from2 lactobacillus brevis atcc 367 Phyre2 PDB 2q80 chain A domain 1 Region: 59 - 354 Aligned: 278 Modelled: 296 Confidence: 100.0% Identity: 19% Fold: Terpenoid synthases Superfamily: Terpenoid synthases Family: Isoprenyl diphosphate synthases Phyre2 1 c3nf2A_ 2 c3mzvB_ 3 c3oyrB_ 4 c1wy0A_ 5 c5h9dB_ 6 c3aqbD_ 7 c1wmwA_ 8 c4lobA_ 9 c3wjnA_ 10 c5jfqB_ 11 d1fpsa_ 12 c6b07B_ 13 c3cp6A_ 14 c4jzbA_ 15 c4dhdA_ 16 c4kk2B_ 17 c2f94F_ 18 c3oacD_ 19 c3n3dB_ 20 d2q80a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99