1

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10

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20

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30

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40

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50

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60

Sequence

M

R

A

T

V

G

L

V

E

A

I

G

I

R

E

L

R

Q

H

A

S

R

Y

L

A

R

V

E

A

G

E

E

L

G

V

T

N

K

G

R

L

V

A

R

L

I

P

V

Q

A

A

E

R

S

R

E

A

L

I

E

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

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70

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80

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90

.

.

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.

.

.

.

Sequence

S

G

V

L

I

P

A

R

R

P

Q

N

L

L

D

V

T

A

E

P

A

R

G

R

K

R

T

L

S

D

V

L

N

E

M

R

D

E

Q

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 40%) Alpha helix ( 46%) Beta strand ( 14%)

Rank Aligned region

PDB 2odk chain D Region: 8 - 48 Aligned: 41 Modelled: 40 Confidence: 99.1% Identity: 17% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein; PDBTitle: putative prevent-host-death protein from nitrosomonas europaea Phyre2 PDB 2odk chain A domain 1 Region: 9 - 48 Aligned: 40 Modelled: 40 Confidence: 99.1% Identity: 18% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 3hry chain A Region: 8 - 48 Aligned: 41 Modelled: 41 Confidence: 98.9% Identity: 37% PDB header:antitoxin Chain: A: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd in a trigonal space group and partially2 disordered Phyre2 PDB 3hs2 chain H Region: 8 - 60 Aligned: 53 Modelled: 53 Confidence: 98.9% Identity: 32% PDB header:antitoxin Chain: H: PDB Molecule:prevent host death protein; PDBTitle: crystal structure of phd truncated to residue 57 in an orthorhombic2 space group Phyre2 PDB 3g5o chain A Region: 7 - 58 Aligned: 52 Modelled: 52 Confidence: 98.5% Identity: 19% PDB header:toxin/antitoxin Chain: A: PDB Molecule:uncharacterized protein rv2865; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis Phyre2 PDB 2a6q chain B domain 1 Region: 8 - 58 Aligned: 51 Modelled: 51 Confidence: 98.4% Identity: 16% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 2a6q chain A domain 1 Region: 8 - 58 Aligned: 51 Modelled: 51 Confidence: 98.3% Identity: 18% Fold: YefM-like Superfamily: YefM-like Family: YefM-like Phyre2 PDB 3oei chain B Region: 10 - 58 Aligned: 48 Modelled: 49 Confidence: 97.4% Identity: 19% PDB header:toxin, protein binding Chain: B: PDB Molecule:relj (antitoxin rv3357); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) Phyre2 PDB 3d55 chain A Region: 10 - 58 Aligned: 48 Modelled: 49 Confidence: 97.2% Identity: 19% PDB header:toxin inhibitor Chain: A: PDB Molecule:uncharacterized protein rv3357/mt3465; PDBTitle: crystal structure of m. tuberculosis yefm antitoxin Phyre2 PDB 3k6q chain B Region: 9 - 45 Aligned: 37 Modelled: 37 Confidence: 80.7% Identity: 19% PDB header:ligand binding protein Chain: B: PDB Molecule:putative ligand binding protein; PDBTitle: crystal structure of an antitoxin part of a putative toxin/antitoxin2 system (swol_0700) from syntrophomonas wolfei subsp. wolfei at 1.80 a3 resolution Phyre2 PDB 1sko chain A Region: 12 - 52 Aligned: 41 Modelled: 41 Confidence: 69.2% Identity: 22% PDB header:signaling protein Chain: A: PDB Molecule:mitogen-activated protein kinase kinase 1 PDBTitle: mp1-p14 complex Phyre2 PDB 3cpt chain A domain 1 Region: 15 - 52 Aligned: 38 Modelled: 38 Confidence: 61.8% Identity: 24% Fold: Profilin-like Superfamily: Roadblock/LC7 domain Family: Roadblock/LC7 domain Phyre2 PDB 1gk7 chain A Region: 6 - 28 Aligned: 23 Modelled: 23 Confidence: 28.8% Identity: 26% PDB header:vimentin Chain: A: PDB Molecule:vimentin; PDBTitle: human vimentin coil 1a fragment (1a) Phyre2 PDB 3s4r chain B Region: 13 - 28 Aligned: 16 Modelled: 16 Confidence: 22.6% Identity: 19% PDB header:structural protein Chain: B: PDB Molecule:vimentin; PDBTitle: crystal structure of vimentin coil1a/1b fragment with a stabilizing2 mutation Phyre2 PDB 2ns0 chain A domain 1 Region: 14 - 42 Aligned: 29 Modelled: 29 Confidence: 18.6% Identity: 31% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: RHA1 ro06458-like Phyre2 PDB 1ogd chain A Region: 16 - 42 Aligned: 27 Modelled: 27 Confidence: 18.5% Identity: 22% Fold: RbsD-like Superfamily: RbsD-like Family: RbsD-like Phyre2 PDB 2wcv chain I Region: 16 - 42 Aligned: 27 Modelled: 27 Confidence: 18.0% Identity: 15% PDB header:isomerase Chain: I: PDB Molecule:l-fucose mutarotase; PDBTitle: crystal structure of bacterial fucu Phyre2 PDB 3e7n chain B Region: 16 - 42 Aligned: 27 Modelled: 27 Confidence: 15.7% Identity: 22% PDB header:transport protein Chain: B: PDB Molecule:d-ribose high-affinity transport system; PDBTitle: crystal structure of d-ribose high-affinity transport system from2 salmonella typhimurium lt2 Phyre2 PDB 3p13 chain B Region: 16 - 42 Aligned: 27 Modelled: 27 Confidence: 14.6% Identity: 22% PDB header:isomerase Chain: B: PDB Molecule:d-ribose pyranase; PDBTitle: complex structure of d-ribose pyranase sa240 with d-ribose Phyre2 PDB 1y8x chain B domain 1 Region: 15 - 37 Aligned: 23 Modelled: 23 Confidence: 14.0% Identity: 30% Fold: Activating enzymes of the ubiquitin-like proteins Superfamily: Activating enzymes of the ubiquitin-like proteins Family: Ubiquitin activating enzymes (UBA) Phyre2 1 c2odkD_ 2 d2odka1 3 c3hryA_ 4 c3hs2H_ 5 c3g5oA_ 6 d2a6qb1 7 d2a6qa1 8 c3oeiB_ 9 c3d55A_ 10 c3k6qB_ 11 c1skoA_ 12 d3cpta1 13 c1gk7A_ 14 c3s4rB_ 15 d2ns0a1 16 d1ogda_ 17 c2wcvI_ 18 c3e7nB_ 19 c3p13B_ 20 d1y8xb1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49