1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	K	L	I	E	Y	D	E	T	A	R	R	A	M	E	V	G	M	D	K	L	A	D	T	V	R	V	T	L	G	P	R	G	R	H	V	V	L	A	K	A	F	G	G	P	T	V	T	N	D	G	V	T	V	A	R	E	I	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	E	D	P	F	E	D	L	G	A	Q	L	V	K	S	V	A	T	K	T	N	D	V	A	G	D	G	T	T	T	A	T	I	L	A	Q	A	L	I	K	G	G	L	R	L	V	A	A	G	V	N	P	I	A	L	G	V	G	I	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	A	A	D	A	V	S	E	A	L	L	A	S	A	T	P	V	S	G	K	T	G	I	A	Q	V	A	T	V	S	S	R	D	E	Q	I	G	D	L	V	G	E	A	M	S	K	V	G	H	D	G	V	V	S	V	E	E	S	S	T
Secondary structure
SS confidence
Disorder															?		?	?													?	?	?	?																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	G	T	E	L	E	F	T	E	G	I	G	F	D	K	G	F	L	S	A	Y	F	V	T	D	F	D	N	Q	Q	A	V	L	E	D	A	L	I	L	L	H	Q	D	K	I	S	S	L	P	D	L	L	P	L	L	E	K	V	A	G
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	G	K	P	L	L	I	V	A	E	D	V	E	G	E	A	L	A	T	L	V	V	N	A	I	R	K	T	L	K	A	V	A	V	K	G	P	Y	F	G	D	R	R	K	A	F	L	E	D	L	A	V	V	T	G	G	Q	V	V	N
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	D	A	G	M	V	L	R	E	V	G	L	E	V	L	G	S	A	R	R	V	V	V	S	K	D	D	T	V	I	V	D	G	G	G	T	A	E	A	V	A	N	R	A	K	H	L	R	A	E	I	D	K	S	D	S	D	W	D	R
Secondary structure
SS confidence
Disorder					?						?																										?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	K	L	G	E	R	L	A	K	L	A	G	G	V	A	V	I	K	V	G	A	A	T	E	T	A	L	K	E	R	K	E	S	V	E	D	A	V	A	A	A	K	A	A	V	E	E	G	I	V	P	G	G	G	A	S	L	I	H	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	R	K	A	L	T	E	L	R	A	S	L	T	G	D	E	V	L	G	V	D	V	F	S	E	A	L	A	A	P	L	F	W	I	A	A	N	A	G	L	D	G	S	V	V	V	N	K	V	S	E	L	P	A	G	H	G	L	N	V
Secondary structure
SS confidence
Disorder										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.
Sequence		N	T	L	S	Y	G	D	L	A	A	D	G	V	I	D	P	V	K	V	T	R	S	A	V	L	N	A	S	S	V	A	R	M	V	L	T	T	E	T	V	V	V	D	K	P	A	K	A	E	D	H	D	H	H	H	G	H	A	H
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 57%) Beta strand ( 12%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 1kp8 chain B Region: 2 - 526 Aligned: 523 Modelled: 525 Confidence: 100.0% Identity: 52% PDB header:chaperone Chain: B: PDB Molecule:groel protein; PDBTitle: structural basis for groel-assisted protein folding from the crystal2 structure of (groel-kmgatp)14 at 2.0 a resolution Phyre2 PDB 1we3 chain D Region: 2 - 526 Aligned: 524 Modelled: 525 Confidence: 100.0% Identity: 54% PDB header:chaperone Chain: D: PDB Molecule:cpn60(groel); PDBTitle: crystal structure of the chaperonin complex cpn60/cpn10/(adp)7 from2 thermus thermophilus Phyre2 PDB 4pj1 chain E Region: 2 - 525 Aligned: 522 Modelled: 524 Confidence: 100.0% Identity: 42% PDB header:chaperone Chain: E: PDB Molecule:60 kda heat shock protein, mitochondrial; PDBTitle: crystal structure of the human mitochondrial chaperonin symmetrical2 'football' complex Phyre2 PDB 1iok chain E Region: 2 - 525 Aligned: 479 Modelled: 492 Confidence: 100.0% Identity: 52% PDB header:chaperone Chain: E: PDB Molecule:chaperonin 60; PDBTitle: crystal structure of chaperonin-60 from paracoccus2 denitrificans Phyre2 PDB 5cdi chain B Region: 5 - 526 Aligned: 521 Modelled: 522 Confidence: 100.0% Identity: 46% PDB header:chaperone Chain: B: PDB Molecule:chaperonin 60b1; PDBTitle: chloroplast chaperonin 60b1 of chlamydomonas Phyre2 PDB 5da8 chain N Region: 2 - 525 Aligned: 508 Modelled: 524 Confidence: 100.0% Identity: 50% PDB header:chaperone Chain: N: PDB Molecule:60 kda chaperonin; PDBTitle: crystal structure of chaperonin groel from Phyre2 PDB 3p9e chain I Region: 7 - 533 Aligned: 495 Modelled: 506 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: I: PDB Molecule: PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 PDB 3iyg chain E Region: 7 - 523 Aligned: 472 Modelled: 481 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: E: PDB Molecule:t-complex protein 1 subunit; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 4b2t chain Q Region: 2 - 524 Aligned: 459 Modelled: 491 Confidence: 100.0% Identity: 22% PDB header:chaperone Chain: Q: PDB Molecule:t-complex protein 1 subunit theta; PDBTitle: the crystal structures of the eukaryotic chaperonin cct2 reveal its functional partitioning Phyre2 PDB 1q2v chain A Region: 7 - 524 Aligned: 479 Modelled: 497 Confidence: 100.0% Identity: 25% PDB header:chaperone Chain: A: PDB Molecule:thermosome alpha subunit; PDBTitle: crystal structure of the chaperonin from thermococcus strain ks-12 (nucleotide-free form) Phyre2 PDB 3izk chain F Region: 7 - 524 Aligned: 459 Modelled: 483 Confidence: 100.0% Identity: 29% PDB header:chaperone Chain: F: PDB Molecule:chaperonin; PDBTitle: mm-cpn rls deltalid with atp Phyre2 PDB 3iyg chain D Region: 8 - 524 Aligned: 464 Modelled: 464 Confidence: 100.0% Identity: 24% PDB header:chaperone Chain: D: PDB Molecule:t-complex protein 1 subunit delta; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 3ko1 chain H Region: 8 - 523 Aligned: 477 Modelled: 491 Confidence: 100.0% Identity: 22% PDB header:chaperone Chain: H: PDB Molecule:chaperonin; PDBTitle: cystal structure of thermosome from acidianus tengchongensis strain s5 Phyre2 PDB 3p9e chain N Region: 7 - 530 Aligned: 484 Modelled: 496 Confidence: 100.0% Identity: 20% PDB header:chaperone Chain: N: PDB Molecule: PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 PDB 3iyg chain A Region: 8 - 525 Aligned: 484 Modelled: 497 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: A: PDB Molecule:t-complex protein 1 subunit alpha; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 4b2t chain E Region: 7 - 523 Aligned: 453 Modelled: 474 Confidence: 100.0% Identity: 23% PDB header:chaperone Chain: E: PDB Molecule:t-complex protein 1 subunit epsilon; PDBTitle: the crystal structures of the eukaryotic chaperonin cct2 reveal its functional partitioning Phyre2 PDB 3iyg chain Z Region: 5 - 523 Aligned: 489 Modelled: 507 Confidence: 100.0% Identity: 20% PDB header:chaperone Chain: Z: PDB Molecule:t-complex protein 1 subunit zeta; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 4b2t chain D Region: 7 - 524 Aligned: 454 Modelled: 486 Confidence: 100.0% Identity: 25% PDB header:chaperone Chain: D: PDB Molecule:t-complex protein 1 subunit delta; PDBTitle: the crystal structures of the eukaryotic chaperonin cct2 reveal its functional partitioning Phyre2 PDB 3p9e chain O Region: 6 - 527 Aligned: 485 Modelled: 488 Confidence: 100.0% Identity: 18% PDB header:chaperone Chain: O: PDB Molecule: PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 PDB 3iyg chain G Region: 8 - 525 Aligned: 479 Modelled: 497 Confidence: 100.0% Identity: 18% PDB header:chaperone Chain: G: PDB Molecule:t-complex protein 1 subunit gamma; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 1 c1kp8B_ 2 c1we3D_ 3 c4pj1E_ 4 c1iokE_ 5 c5cdiB_ 6 c5da8N_ 7 c3p9ei_ 8 c3iygE_ 9 c4b2tQ_ 10 c1q2vA_ 11 c3izkF_ 12 c3iygD_ 13 c3ko1H_ 14 c3p9en_ 15 c3iygA_ 16 c4b2tE_ 17 c3iygZ_ 18 c4b2tD_ 19 c3p9eo_ 20 c3iygG_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99