1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	T	I	A	Q	R	L	R	D	D	H	G	V	A	A	S	E	S	S	V	R	R	W	I	A	T	H	F	A	E	E	V	A	R	E	R	V	T	V	P	R	G	P	V	D	A	G	S	E	A	Q	I	D	Y	G	R	L	G	M
Secondary structure
SS confidence
Disorder		?	?	?																											?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	F	D	P	A	T	A	R	R	V	A	V	W	A	F	V	M	V	L	A	F	S	R	H	L	F	V	R	P	V	I	R	M	D	Q	T	A	W	C	A	C	H	V	A	A	F	E	F	F	D	G	V	P	A	R	L	V	C	D	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	T	G	V	D	K	P	D	L	Y	D	P	Q	I	N	R	S	Y	A	E	L	A	S	H	Y	A	T	L	V	D	P	A	R	A	R	K	P	K	D	K	P	R	V	E	R	P	M	T	Y	V	R	D	S	F	W	K	G	R	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	D	S	L	A	Q	M	Q	Q	A	A	V	T	W	S	T	E	V	A	G	L	R	Y	L	R	A	L	E	G	A	Q	P	L	R	M	F	E	A	V	E	Q	Q	A	L	I	A	L	P	P	R	A	F	E	L	T	S	W	S	I	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	V	G	V	D	T	H	L	K	V	G	K	A	L	Y	S	V	P	W	R	L	I	G	Q	R	L	H	A	R	T	A	G	D	V	V	Q	I	F	A	G	N	D	V	V	A	T	H	V	R	R	P	S	G	R	S	T	D	F	S	H
Secondary structure
SS confidence
Disorder																																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	P	P	E	K	I	A	F	H	M	R	T	P	T	W	C	R	H	T	A	E	L	V	G	P	A	S	Q	Q	V	I	A	E	F	M	R	D	N	A	I	H	H	L	R	S	A	Q	G	V	L	G	L	R	D	K	H	G	C	D	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410
Sequence		L	E	A	A	C	A	R	A	I	E	V	G	D	P	S	Y	R	T	I	K	G	I	L	V	A	G	T	E	H	A	A	N	E	P	T	T	S	S	P	A	S	T	A	G	G	V	P	A	R	P
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 42%) Beta strand ( 22%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 4fcy chain A Region: 1 - 286 Aligned: 271 Modelled: 286 Confidence: 100.0% Identity: 15% PDB header:dna binding protein/dna Chain: A: PDB Molecule:transposase; PDBTitle: crystal structure of the bacteriophage mu transpososome Phyre2 PDB 1bco chain A Region: 43 - 286 Aligned: 244 Modelled: 243 Confidence: 99.9% Identity: 9% PDB header:transposase Chain: A: PDB Molecule:bacteriophage mu transposase; PDBTitle: bacteriophage mu transposase core domain Phyre2 PDB 1bco chain A domain 2 Region: 46 - 228 Aligned: 183 Modelled: 183 Confidence: 99.8% Identity: 8% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: mu transposase, core domain Phyre2 PDB 5u1c chain A Region: 5 - 262 Aligned: 228 Modelled: 248 Confidence: 99.8% Identity: 8% PDB header:viral protein Chain: A: PDB Molecule:hiv-1 integrase, sso7d chimera; PDBTitle: structure of tetrameric hiv-1 strand transfer complex intasome Phyre2 PDB 5cz1 chain B Region: 46 - 217 Aligned: 148 Modelled: 172 Confidence: 99.8% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 1c0m chain A Region: 42 - 216 Aligned: 155 Modelled: 175 Confidence: 99.8% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:protein (integrase); PDBTitle: crystal structure of rsv two-domain integrase Phyre2 PDB 3f9k chain V Region: 5 - 217 Aligned: 173 Modelled: 201 Confidence: 99.8% Identity: 12% PDB header:viral protein, recombination Chain: V: PDB Molecule:integrase; PDBTitle: two domain fragment of hiv-2 integrase in complex with ledgf ibd Phyre2 PDB 3nf9 chain A Region: 47 - 219 Aligned: 146 Modelled: 173 Confidence: 99.8% Identity: 10% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 3jca chain E Region: 5 - 227 Aligned: 200 Modelled: 213 Confidence: 99.8% Identity: 15% PDB header:viral protein Chain: E: PDB Molecule:integrase; PDBTitle: core model of the mouse mammary tumor virus intasome Phyre2 PDB 1asu chain A Region: 42 - 212 Aligned: 151 Modelled: 171 Confidence: 99.8% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1c0m chain A domain 2 Region: 42 - 217 Aligned: 156 Modelled: 176 Confidence: 99.7% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 5m0r chain F Region: 5 - 217 Aligned: 175 Modelled: 194 Confidence: 99.7% Identity: 17% PDB header:hydrolase Chain: F: PDB Molecule:integrase; PDBTitle: cryo-em reconstruction of the maedi-visna virus (mvv) strand transfer2 complex Phyre2 PDB 1ex4 chain A Region: 45 - 216 Aligned: 142 Modelled: 161 Confidence: 99.7% Identity: 11% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: hiv-1 integrase catalytic core and c-terminal domain Phyre2 PDB 1exq chain A Region: 45 - 218 Aligned: 140 Modelled: 174 Confidence: 99.7% Identity: 10% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3kks chain B Region: 49 - 225 Aligned: 150 Modelled: 177 Confidence: 99.7% Identity: 14% PDB header:dna binding protein Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of catalytic core domain of biv integrase in crystal2 form ii Phyre2 PDB 4mq3 chain A Region: 49 - 201 Aligned: 128 Modelled: 153 Confidence: 99.6% Identity: 11% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 1cxq chain A Region: 45 - 200 Aligned: 134 Modelled: 146 Confidence: 99.6% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 1hyv chain A Region: 47 - 218 Aligned: 133 Modelled: 160 Confidence: 99.6% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3hpg chain C Region: 5 - 216 Aligned: 172 Modelled: 212 Confidence: 99.6% Identity: 17% PDB header:transferase Chain: C: PDB Molecule:integrase; PDBTitle: visna virus integrase (residues 1-219) in complex with ledgf2 ibd: examples of open integrase dimer-dimer interfaces Phyre2 PDB 1k6y chain B Region: 5 - 216 Aligned: 164 Modelled: 212 Confidence: 99.6% Identity: 9% PDB header:transferase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of a two-domain fragment of hiv-1 integrase Phyre2 1 c4fcyA_ 2 c1bcoA_ 3 d1bcoa2 4 c5u1cA_ 5 c5cz1B_ 6 c1c0mA_ 7 c3f9kV_ 8 c3nf9A_ 9 c3jcaE_ 10 d1asua_ 11 d1c0ma2 12 c5m0rF_ 13 c1ex4A_ 14 d1exqa_ 15 c3kksB_ 16 c4mq3A_ 17 d1cxqa_ 18 d1hyva_ 19 c3hpgC_ 20 c1k6yB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99