Phyre Home Retrieve Phyre Job Id
Emailmdejesus@rockefeller.edu
DescriptionRVBD3437_(-)_3857091_3857567
DateFri Aug 9 18:20:11 BST 2019
Unique Job ID0ee5dbd4b9890d55
SequenceMVGRAVPSPN ... Download FASTA
Job Typenormal
Job Expiry

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:24.752 Y:25.328 Z:19.741
Model (left) based on template c4rohA_
Top template information
PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase itchy homolog;
PDBTitle: crystal structure of tandem ww domains of itch in complex with txnip2 peptide
Confidence and coverage
Confidence: 72.3% Coverage: 20%
31 residues ( 20% of your sequence) have been modelled with 72.3% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
3D viewing
Interactive 3D view in JSmol
For other options to view your downloaded structure offline see the FAQ

Sequence analysis 

Download FASTA version

Secondary structure and disorder prediction [Show] 

Domain analysis [Show] 

Detailed template information [Hide] 

 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c4rohA_
72.3 32
PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase itchy homolog;
PDBTitle: crystal structure of tandem ww domains of itch in complex with txnip2 peptide
2d2jmfa1
71.7 33
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
3c3l4hA_
66.1 26
PDB header:protein binding
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase hecw1;
PDBTitle: helical box domain and second ww domain of the human e3 ubiquitin-2 protein ligase hecw1
4c1yiuA_
64.3 33
PDB header:ligase
Chain: A: PDB Molecule:itchy e3 ubiquitin protein ligase;
PDBTitle: itch e3 ubiquitin ligase ww3 domain
5c2lawA_
60.2 33
PDB header:signaling protein/transcription
Chain: A: PDB Molecule:yorkie homolog;
PDBTitle: structure of the second ww domain from human yap in complex with a2 human smad1 derived peptide
6c2kykA_
59.3 33
PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase itchy homolog;
PDBTitle: the sandwich region between two lmp2a py motif regulates the2 interaction between aip4ww2domain and py motif
7c2ysdA_
54.8 21
PDB header:protein binding
Chain: A: PDB Molecule:membrane-associated guanylate kinase, ww and pdz
PDBTitle: solution structure of the first ww domain from the human2 membrane-associated guanylate kinase, ww and pdz domain-3 containing protein 1. magi-1
8c2l4jA_
54.0 26
PDB header:transcription
Chain: A: PDB Molecule:yes-associated protein 2 (yap2);
PDBTitle: yap ww2
9c1ymzA_
52.8 31
PDB header:unknown function
Chain: A: PDB Molecule:cc45;
PDBTitle: cc45, an artificial ww domain designed using statistical2 coupling analysis
10c2ez5W_
52.7 18
PDB header:signalling protein,ligase
Chain: W: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: solution structure of the dnedd4 ww3* domain- comm lpsy2 peptide complex
11c2djyA_
51.9 30
PDB header:ligase/signaling protein
Chain: A: PDB Molecule:smad ubiquitination regulatory factor 2;
PDBTitle: solution structure of smurf2 ww3 domain-smad7 py peptide2 complex
12d1i5hw_
50.0 24
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
13c2ysbA_
49.2 26
PDB header:protein binding
Chain: A: PDB Molecule:salvador homolog 1 protein;
PDBTitle: solution structure of the first ww domain from the mouse2 salvador homolog 1 protein (sav1)
14d1tk7a1
48.0 22
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
15c2jmfA_
45.7 33
PDB header:ligase/signaling protein
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase suppressor of deltex;
PDBTitle: solution structure of the su(dx) ww4- notch py peptide2 complex
16c1wr7A_
44.7 27
PDB header:ligase
Chain: A: PDB Molecule:nedd4-2;
PDBTitle: solution structure of the third ww domain of nedd4-2
17d1tk7a2
44.5 33
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
18c5ydyA_
43.7 30
PDB header:signaling protein
Chain: A: PDB Molecule:ww2 domain and ppxy motif complex;
PDBTitle: nmr structure of yap1-2 ww2 domain with lats1 ppxy motif complex
19c2mdjA_
42.9 26
PDB header:transferase
Chain: A: PDB Molecule:histone-lysine n-methyltransferase setd2;
PDBTitle: solution structure of ww domain with polyproline stretch (pp2ww) of2 hypb
20d1f8ab1
41.8 25
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
21c2n8tA_
not modelled 41.2 25
PDB header:ligase/peptide
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: solution structure of the rnedd4 ww2 domain-cx43ct peptide complex by2 nmr
22c1wmvA_
not modelled 40.9 27
PDB header:oxidoreductase, apoptosis
Chain: A: PDB Molecule:ww domain containing oxidoreductase;
PDBTitle: solution structure of the second ww domain of wwox
23c2dmvA_
not modelled 40.2 24
PDB header:ligase
Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase;
PDBTitle: solution structure of the second ww domain of itchy homolog2 e3 ubiquitin protein ligase (itch)
24c1wr4A_
not modelled 40.0 31
PDB header:ligase
Chain: A: PDB Molecule:ubiquitin-protein ligase nedd4-2;
PDBTitle: solution structure of the second ww domain of nedd4-2
25c2e3uA_
not modelled 39.6 27
PDB header:rna binding protein
Chain: A: PDB Molecule:hypothetical protein ph1566;
PDBTitle: crystal structure analysis of dim2p from pyrococcus horikoshii ot3
26c1e0mA_
not modelled 39.5 30
PDB header:de novo protein
Chain: A: PDB Molecule:wwprototype;
PDBTitle: prototype ww domain
27c2ysgA_
not modelled 37.7 24
PDB header:protein binding
Chain: A: PDB Molecule:syntaxin-binding protein 4;
PDBTitle: solution structure of the ww domain from the human syntaxin-2 binding protein 4
28c1tuaA_
not modelled 37.1 25
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:hypothetical protein ape0754;
PDBTitle: 1.5 a crystal structure of a protein of unknown function2 ape0754 from aeropyrum pernix
29c2dwvB_
not modelled 33.8 17
PDB header:protein binding
Chain: B: PDB Molecule:salvador homolog 1 protein;
PDBTitle: solution structure of the second ww domain from mouse2 salvador homolog 1 protein (mww45)
30c2ysfA_
not modelled 29.2 18
PDB header:protein binding
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase itchy homolog;
PDBTitle: solution structure of the fourth ww domain from the human2 e3 ubiquitin-protein ligase itchy homolog, itch
31d1k9ra_
not modelled 29.0 35
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
32c2kq0A_
not modelled 27.5 25
PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: human nedd4 3rd ww domain complex with ebola zaire virus matrix2 protein vp40 derived peptide ilptappeymea
33d1tuaa2
not modelled 26.6 25
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
34c2c36B_
not modelled 26.4 22
PDB header:viral protein
Chain: B: PDB Molecule:glycoprotein d hsv-1;
PDBTitle: structure of unliganded hsv gd reveals a mechanism for receptor-2 mediated activation of virus entry
35c1tk7A_
not modelled 26.1 27
PDB header:signaling protein
Chain: A: PDB Molecule:cg4244-pb;
PDBTitle: nmr structure of ww domains (ww3-4) from suppressor of2 deltex
36c4b8tA_
not modelled 25.4 22
PDB header:transcription/rna
Chain: A: PDB Molecule:kh-type splicing regulatory protein;
PDBTitle: rna binding protein solution structure of the third kh2 domain of ksrp in complex with the g-rich target sequence.
37c6g18x_
not modelled 24.3 17
PDB header:ribosome
Chain: X: PDB Molecule:40s ribosomal protein s23;
PDBTitle: cryo-em structure of a late human pre-40s ribosomal subunit - state c
38c5ydxA_
not modelled 24.1 38
PDB header:signaling protein
Chain: A: PDB Molecule:ww domain with ppxy motif;
PDBTitle: nmr structure of yap1-2 ww1 domain with lats1 ppxy motif complex
39d1nmva1
not modelled 23.5 24
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
40c2dl0A_
not modelled 23.3 32
PDB header:signaling protein
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sam-domain of the sam and sh32 domain containing protein 1
41d1dt4a_
not modelled 23.0 28
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
42d2itka1
not modelled 21.6 25
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
43c2yshA_
not modelled 20.8 29
PDB header:protein binding
Chain: A: PDB Molecule:growth-arrest-specific protein 7;
PDBTitle: solution structure of the ww domain from the human growth-2 arrest-specific protein 7, gas-7
44c2yscA_
not modelled 19.9 37
PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family
PDBTitle: solution structure of the ww domain from the human amyloid2 beta a4 precursor protein-binding family b member 3, apbb3
45d2f21a1
not modelled 19.8 29
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
46c2kxqA_
not modelled 19.3 18
PDB header:protein binding
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf2;
PDBTitle: solution structure of smurf2 ww2 and ww3 bound to smad7 py motif2 containing peptide
47c2ysiA_
not modelled 16.6 17
PDB header:protein binding
Chain: A: PDB Molecule:transcription elongation regulator 1;
PDBTitle: solution structure of the first ww domain from the mouse2 transcription elongation regulator 1, transcription factor3 ca150
48d1ec6a_
not modelled 16.3 31
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
49d2ho2a1
not modelled 15.6 43
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
50d1pina1
not modelled 15.1 28
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
51c2lb0A_
not modelled 15.0 21
PDB header:signaling protein/transcription
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf1;
PDBTitle: structure of the first ww domain of human smurf1 in complex with a di-2 phosphorylated human smad1 derived peptide
52d2dsya1
not modelled 14.7 33
Fold:TTHA1013/TTHA0281-like
Superfamily:TTHA1013/TTHA0281-like
Family:TTHA0281-like
53c6emlp_
not modelled 14.2 17
PDB header:ribosome
Chain: P: PDB Molecule:40s ribosomal protein s0-a;
PDBTitle: cryo-em structure of a late pre-40s ribosomal subunit from2 saccharomyces cerevisiae
54c2zajA_
not modelled 13.7 19
PDB header:protein binding
Chain: A: PDB Molecule:membrane-associated guanylate kinase, ww and pdz
PDBTitle: solution structure of the short-isoform of the second ww2 domain from the human membrane-associated guanylate kinase,3 ww and pdz domain-containing protein 1 (magi-1)
55d1i8gb_
not modelled 13.4 29
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
56d1dtja_
not modelled 13.1 26
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
57c2lazA_
not modelled 12.9 21
PDB header:signaling protein/transcription
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf1;
PDBTitle: structure of the first ww domain of human smurf1 in complex with a2 mono-phosphorylated human smad1 derived peptide
58d1x4ma1
not modelled 11.8 12
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
59c5u3kC_
not modelled 11.1 22
PDB header:immune system/viral protein
Chain: C: PDB Molecule:gp41 mper peptide;
PDBTitle: crystal structure of dh511.2 fab in complex with hiv-1 gp41 mper 662-2 683 peptide
60d2ysca1
not modelled 10.8 41
Fold:WW domain-like
Superfamily:WW domain
Family:WW domain
61c5u3kP_
not modelled 10.6 22
PDB header:immune system/viral protein
Chain: P: PDB Molecule:gp41 mper peptide;
PDBTitle: crystal structure of dh511.2 fab in complex with hiv-1 gp41 mper 662-2 683 peptide
62c1loiA_
not modelled 10.4 100
PDB header:hydrolase
Chain: A: PDB Molecule:cyclic 3',5'-amp specific phosphodiesterase rd1;
PDBTitle: n-terminal splice region of rat c-amp phosphodiesterase,2 nmr, 7 structures
63c2w0cS_
not modelled 10.3 29
PDB header:virus
Chain: S: PDB Molecule:protein p3;
PDBTitle: x-ray structure of the entire lipid-containing bacteriophage pm2
64c6htnE_
not modelled 10.3 23
PDB header:sugar binding protein
Chain: E: PDB Molecule:fucose-binding lectin;
PDBTitle: structure of a fucose lectin from kordia zhangzhouensis in complex2 with methyl-fucoside
65d1xmeb2
not modelled 10.2 35
Fold:Transmembrane helix hairpin
Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region
Family:Cytochrome c oxidase subunit II-like, transmembrane region
66c2hh2A_
not modelled 9.7 25
PDB header:rna binding protein
Chain: A: PDB Molecule:kh-type splicing regulatory protein;
PDBTitle: solution structure of the fourth kh domain of ksrp
67c1javA_
not modelled 9.2 22
PDB header:viral protein
Chain: A: PDB Molecule:transmembrane glycoprotein (gp41);
PDBTitle: average nmr solution structure of the trp-rich peptide of2 hiv gp41 bound to dpc micelles
68c2g57A_
not modelled 8.9 67
PDB header:oncoprotein
Chain: A: PDB Molecule:beta-catenin;
PDBTitle: structure of the phosphorylation motif of the oncogenic2 protein beta-catenin recognized by a selective monoclonal3 antibody
69c1jauA_
not modelled 8.8 22
PDB header:viral protein
Chain: A: PDB Molecule:transmembrane glycoprotein (gp41);
PDBTitle: nmr solution structure of the trp-rich peptide of hiv gp412 bound to dpc micelles
70d3bmva3
not modelled 8.7 56
Fold:Glycosyl hydrolase domain
Superfamily:Glycosyl hydrolase domain
Family:alpha-Amylases, C-terminal beta-sheet domain
71d1smpi_
not modelled 7.9 39
Fold:Streptavidin-like
Superfamily:beta-Barrel protease inhibitors
Family:Metalloprotease inhibitor
72c6mttP_
not modelled 7.8 22
PDB header:immune system
Chain: P: PDB Molecule:rv217 founder virus gp41 peptide;
PDBTitle: crystal structure of vrc46.01 fab in complex with gp41 peptide
73c2dgrA_
not modelled 7.6 18
PDB header:rna binding protein
Chain: A: PDB Molecule:ring finger and kh domain-containing protein 1;
PDBTitle: solution structure of the second kh domain in ring finger2 and kh domain containing protein 1
74d1lgha_
not modelled 7.4 43
Fold:Light-harvesting complex subunits
Superfamily:Light-harvesting complex subunits
Family:Light-harvesting complex subunits
75c2pv6A_
not modelled 7.3 22
PDB header:viral protein
Chain: A: PDB Molecule:envelope glycoprotein;
PDBTitle: hiv-1 gp41 membrane proximal ectodomain region peptide in2 dpc micelle
76c6acvA_
not modelled 7.1 15
PDB header:dna binding protein
Chain: A: PDB Molecule:methyl-cpg-binding domain-containing protein 11;
PDBTitle: the solution nmr structure of mbd domain
77c4ce41_
not modelled 6.9 50
PDB header:ribosome
Chain: 1: PDB Molecule:mrpl28;
PDBTitle: 39s large subunit of the porcine mitochondrial ribosome
78c5wvmA_
not modelled 6.7 35
PDB header:sugar binding protein
Chain: A: PDB Molecule:maltose-binding periplasmic protein,two-component system
PDBTitle: crystal structure of baes cocrystallized with 2 mm indole
79c4pqkA_
not modelled 6.7 55
PDB header:dna binding protein
Chain: A: PDB Molecule:maltose abc transporter periplasmic protein, truncated
PDBTitle: c-terminal domain of dna binding protein
80c4v3aC_
not modelled 6.5 70
PDB header:transport protein
Chain: C: PDB Molecule:pleurotolysin b;
PDBTitle: membrane bound pleurotolysin prepore (tmh1 lock) trapped with2 engineered disulphide cross-link
81c3j20W_
not modelled 6.4 38
PDB header:ribosome
Chain: W: PDB Molecule:30s ribosomal protein s27e;
PDBTitle: promiscuous behavior of proteins in archaeal ribosomes revealed by2 cryo-em: implications for evolution of eukaryotic ribosomes (30s3 ribosomal subunit)
82d1j4wa2
not modelled 6.4 22
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
83c2me1A_
not modelled 6.4 22
PDB header:membrane protein
Chain: A: PDB Molecule:gp41;
PDBTitle: hiv-1 gp41 clade b double alanine mutant membrane proximal external2 region peptide in dpc micelle
84c4ol4A_
not modelled 6.0 13
PDB header:lipid binding protein
Chain: A: PDB Molecule:proline-rich 28 kda antigen;
PDBTitle: crystal structure of secreted proline rich antigen mtc28 (rv0040c)2 from mycobacterium tuberculosis
85c3cglF_
not modelled 5.9 56
PDB header:fluorescent protein
Chain: F: PDB Molecule:gfp-like fluorescent chromoprotein dsfp483;
PDBTitle: crystal structure and raman studies of dsfp483, a cyan fluorescent2 protein from discosoma striata
86c2mnsA_
not modelled 5.8 36
PDB header:membrane protein
Chain: A: PDB Molecule:membrane fusion protein p15;
PDBTitle: solution nmr structure of the reovirus p15 fusion-associated small2 transmembrane (fast) protein fusion-inducing lipid packing sensor3 (flips) motif in dodecyl phosphocholine (dpc) micelles
87d2ctla1
not modelled 5.7 29
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
88d1wvna1
not modelled 5.7 18
Fold:Eukaryotic type KH-domain (KH-domain type I)
Superfamily:Eukaryotic type KH-domain (KH-domain type I)
Family:Eukaryotic type KH-domain (KH-domain type I)
89c4p1nA_
not modelled 5.6 36
PDB header:protein transport
Chain: A: PDB Molecule:atg1 tmit;
PDBTitle: crystal structure of atg1-atg13 complex
90c2jniA_
not modelled 5.6 83
PDB header:antimicrobial protein
Chain: A: PDB Molecule:arenicin-2;
PDBTitle: spatial structure of antimicrobial peptide arenicin-2 in2 aqueous solution
91c2l8xB_
not modelled 5.6 83
PDB header:antimicrobial protein
Chain: B: PDB Molecule:arenicin-2;
PDBTitle: spatial structure of antimicrobial peptide arenicin-2 dimer in dpc2 micelles
92c2jsbA_
not modelled 5.6 83
PDB header:antimicrobial protein
Chain: A: PDB Molecule:arenicin-1;
PDBTitle: solution structure of arenicin-1
93c2y5pB_
not modelled 5.5 22
PDB header:protein binding
Chain: B: PDB Molecule:internalin b;
PDBTitle: b-repeat of listeria monocytogenes inlb (internalin b)
94c3uiyA_
not modelled 5.4 50
PDB header:structural protein
Chain: A: PDB Molecule:chimera protein of sefd and sefa;
PDBTitle: crystal structure of sefd_dsca in h2o
95c2l8xA_
not modelled 5.4 83
PDB header:antimicrobial protein
Chain: A: PDB Molecule:arenicin-2;
PDBTitle: spatial structure of antimicrobial peptide arenicin-2 dimer in dpc2 micelles
96c2jzxA_
not modelled 5.3 23
PDB header:rna binding protein
Chain: A: PDB Molecule:poly(rc)-binding protein 2;
PDBTitle: pcbp2 kh1-kh2 domains
97c3vxvA_
not modelled 5.1 67
PDB header:hydrolase/dna
Chain: A: PDB Molecule:methyl-cpg-binding domain protein 4;
PDBTitle: crystal structure of methyl cpg binding domain of mbd4 in complex with2 the 5mcg/tg sequence

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite