1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	R	L	F	G	T	D	G	V	R	G	V	A	N	R	E	L	T	A	E	L	A	L	A	L	G	A	A	A	A	R	R	L	S	R	S	G	A	P	G	R	R	V	A	V	L	G	R	D	P	R	A	S	G	E	M	L	E	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																													?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	I	A	G	L	T	S	E	G	V	D	A	L	R	V	G	V	L	P	T	P	A	V	A	Y	L	T	G	A	Y	D	A	D	F	G	V	M	I	S	A	S	H	N	P	M	P	D	N	G	I	K	I	F	G	P	G	G	H	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	D	D	D	T	E	D	Q	I	E	D	L	V	L	G	V	S	R	G	P	G	L	R	P	A	G	A	G	I	G	R	V	I	D	A	E	D	A	T	E	R	Y	L	R	H	V	A	K	A	A	T	A	R	L	D	D	L	A	V	V
Secondary structure
SS confidence
Disorder			?																	?				?																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	D	C	A	H	G	A	A	S	S	A	A	P	R	A	Y	R	A	A	G	A	R	V	I	A	I	N	A	E	P	N	G	R	N	I	N	D	G	C	G	S	T	H	L	D	P	L	R	A	A	V	L	A	H	R	A	D	L	G	L
Secondary structure
SS confidence
Disorder																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	H	D	G	D	A	D	R	C	L	A	V	D	A	N	G	D	L	V	D	G	D	A	I	M	V	V	L	A	L	A	M	K	E	A	G	E	L	A	C	N	T	L	V	A	T	V	M	S	N	L	G	L	H	L	A	M	R	S	A
Secondary structure
SS confidence
Disorder																																				?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	V	T	V	R	T	T	A	V	G	D	R	Y	V	L	E	E	L	R	A	G	D	Y	S	L	G	G	E	Q	S	G	H	I	V	M	P	A	L	G	S	T	G	D	G	I	V	T	G	L	R	L	M	T	R	M	V	Q	T	G	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	L	S	D	L	A	S	A	M	R	T	L	P	Q	V	L	I	N	V	E	V	V	D	K	A	T	A	A	A	A	P	S	V	R	T	A	V	E	Q	A	A	A	E	L	G	D	T	G	R	I	L	L	R	P	S	G	T	E	P	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.
Sequence		I	R	V	M	V	E	A	A	D	E	G	V	A	Q	R	L	A	A	T	V	A	D	A	V	S	T	A	R
Secondary structure
SS confidence
Disorder																											?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 41%) Beta strand ( 21%)

Rank Aligned region

PDB 3pdk chain B Region: 3 - 447 Aligned: 440 Modelled: 445 Confidence: 100.0% Identity: 48% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucosamine mutase; PDBTitle: crystal structure of phosphoglucosamine mutase from b. anthracis Phyre2 PDB 6gyz chain B Region: 3 - 447 Aligned: 442 Modelled: 445 Confidence: 100.0% Identity: 47% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucosamine mutase; PDBTitle: crystal structure of glmm from staphylococcus aureus Phyre2 PDB 1wqa chain B Region: 1 - 447 Aligned: 438 Modelled: 447 Confidence: 100.0% Identity: 35% PDB header:isomerase Chain: B: PDB Molecule:phospho-sugar mutase; PDBTitle: crystal structure of pyrococcus horikoshii2 phosphomannomutase/phosphoglucomutase complexed with mg2+ Phyre2 PDB 2f7l chain A Region: 1 - 446 Aligned: 437 Modelled: 446 Confidence: 100.0% Identity: 29% PDB header:isomerase Chain: A: PDB Molecule:455aa long hypothetical phospho-sugar mutase; PDBTitle: crystal structure of sulfolobus tokodaii2 phosphomannomutase/phosphoglucomutase Phyre2 PDB 3i3w chain B Region: 3 - 447 Aligned: 436 Modelled: 445 Confidence: 100.0% Identity: 37% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucosamine mutase; PDBTitle: structure of a phosphoglucosamine mutase from francisella tularensis Phyre2 PDB 3c04 chain A Region: 3 - 448 Aligned: 429 Modelled: 436 Confidence: 100.0% Identity: 27% PDB header:isomerase Chain: A: PDB Molecule:phosphomannomutase/phosphoglucomutase; PDBTitle: structure of the p368g mutant of pmm/pgm from p. aeruginosa Phyre2 PDB 3uw2 chain A Region: 1 - 448 Aligned: 431 Modelled: 448 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:phosphoglucomutase/phosphomannomutase family protein; PDBTitle: x-ray crystal structure of phosphoglucomutase/phosphomannomutase2 family protein (bth_i1489)from burkholderia thailandensis Phyre2 PDB 5bmp chain A Region: 3 - 445 Aligned: 428 Modelled: 443 Confidence: 100.0% Identity: 25% PDB header:isomerase Chain: A: PDB Molecule:phosphoglucomutase; PDBTitle: crystal structure of phosphoglucomutase from xanthomonas citri2 complexed with glucose-1-phosphate Phyre2 PDB 2fuv chain B Region: 2 - 447 Aligned: 442 Modelled: 444 Confidence: 100.0% Identity: 23% PDB header:isomerase Chain: B: PDB Molecule:phosphoglucomutase; PDBTitle: phosphoglucomutase from salmonella typhimurium. Phyre2 PDB 1tuo chain A Region: 2 - 445 Aligned: 424 Modelled: 444 Confidence: 100.0% Identity: 25% PDB header:biosynthetic protein Chain: A: PDB Molecule:putative phosphomannomutase; PDBTitle: crystal structure of putative phosphomannomutase from2 thermus thermophilus hb8 Phyre2 PDB 1c4g chain B Region: 5 - 447 Aligned: 441 Modelled: 443 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:protein (alpha-d-glucose 1-phosphate phosphoglucomutase); PDBTitle: phosphoglucomutase vanadate based transition state analog complex Phyre2 PDB 4hjh chain A Region: 2 - 447 Aligned: 427 Modelled: 446 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:phosphomannomutase; PDBTitle: iodide sad phased crystal structure of a phosphoglucomutase from2 brucella melitensis complexed with glucose-6-phosphate Phyre2 PDB 2z0f chain A Region: 1 - 447 Aligned: 421 Modelled: 425 Confidence: 100.0% Identity: 24% PDB header:isomerase Chain: A: PDB Molecule:putative phosphoglucomutase; PDBTitle: crystal structure of putative phosphoglucomutase from thermus2 thermophilus hb8 Phyre2 PDB 1kfi chain A Region: 5 - 448 Aligned: 442 Modelled: 444 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: A: PDB Molecule:phosphoglucomutase 1; PDBTitle: crystal structure of the exocytosis-sensitive2 phosphoprotein, pp63/parafusin (phosphoglucomutase) from3 paramecium Phyre2 PDB 4qg5 chain D Region: 24 - 430 Aligned: 405 Modelled: 407 Confidence: 100.0% Identity: 21% PDB header:isomerase Chain: D: PDB Molecule:putative phosphoglucomutase; PDBTitle: crystal structure of phosphoglucomutase from leishmania major at 3.52 angstrom resolution Phyre2 PDB 2dkd chain A Region: 26 - 445 Aligned: 403 Modelled: 406 Confidence: 100.0% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:phosphoacetylglucosamine mutase; PDBTitle: crystal structure of n-acetylglucosamine-phosphate mutase,2 a member of the alpha-d-phosphohexomutase superfamily, in3 the product complex Phyre2 PDB 4bju chain B Region: 28 - 447 Aligned: 404 Modelled: 406 Confidence: 100.0% Identity: 25% PDB header:isomerase Chain: B: PDB Molecule:n-acetylglucosamine-phosphate mutase; PDBTitle: genetic and structural validation of aspergillus fumigatus2 n-acetylphosphoglucosamine mutase as an antifungal target Phyre2 PDB 1p5d chain X domain 1 Region: 2 - 156 Aligned: 143 Modelled: 155 Confidence: 100.0% Identity: 31% Fold: Phosphoglucomutase, first 3 domains Superfamily: Phosphoglucomutase, first 3 domains Family: Phosphoglucomutase, first 3 domains Phyre2 PDB 1kfi chain A domain 1 Region: 5 - 139 Aligned: 135 Modelled: 135 Confidence: 100.0% Identity: 22% Fold: Phosphoglucomutase, first 3 domains Superfamily: Phosphoglucomutase, first 3 domains Family: Phosphoglucomutase, first 3 domains Phyre2 PDB 3pmg chain A domain 1 Region: 5 - 172 Aligned: 166 Modelled: 168 Confidence: 100.0% Identity: 20% Fold: Phosphoglucomutase, first 3 domains Superfamily: Phosphoglucomutase, first 3 domains Family: Phosphoglucomutase, first 3 domains Phyre2 1 c3pdkB_ 2 c6gyzB_ 3 c1wqaB_ 4 c2f7lA_ 5 c3i3wB_ 6 c3c04A_ 7 c3uw2A_ 8 c5bmpA_ 9 c2fuvB_ 10 c1tuoA_ 11 c1c4gB_ 12 c4hjhA_ 13 c2z0fA_ 14 c1kfiA_ 15 c4qg5D_ 16 c2dkdA_ 17 c4bjuB_ 18 d1p5dx1 19 d1kfia1 20 d3pmga1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126